Medical College of Wisconsin Mellowes Center Research Resources
Under the leadership of Raul A. Urrutia, MD, Professor and Director of the Mellowes Center for Genomic Sciences and Precision Medicine, the Mellowes Center partners with researchers, clinicians, and students across MCW to facilitate multidisciplinary collaborations and team-science programs that transform how we understand, treat, and diagnose disease.
Going Beyond DNA
The Mellowes Center takes the understanding of genetics to new heights by investigating diseases caused by the dysregulation of the epigenome – layers of regulation that determine if and when a cell can access and express genes. We support flexible and comprehensive core services (standardized discrete analyses for human and many model species with established turn-around time) and collaborative approaches (greater customization) that lead to new lab discoveries and translate to novel clinical trials and better patient care.
Partner With Us On Your Project
To begin the process, we invite you to schedule a complimentary consultation with our subject matter experts to help our team learn about your research focus and gain an understanding about your specific sequencing, high-throughput assay, and/or analysis needs.
Project Plan
After the consultation, we will generate a statement of work (SOW) that describes the project details including sample type, preparation processes, analytic report components, and a cost estimate with timeline for your project.
Our pricing is competitive to other academic research service providers.
Project Execution
- Agree to statement of work (SOW)
- Designate funding through iLab
- Coordinate drop-off of samples
- Sample processing begins, including:
- sample quality checks (with feedback)
- library prep
- sequencing
- bioinformatics data analysis
Project Completion
- Delivery of raw data and analysis report through web portal or direct transfer to RCC space
- Virtual meeting to walk through the analysis report
- Determine if follow up experiments or additional analysis is needed
- Optional: Data upload to publicly available resources, methods writing and collaborative generation of publication quality figures
Services We Offer
General
- Specialized Extractions
- Fragment Analysis Quality Control
DNA
- Whole Genome Sequencing (WGS)
- Whole Exome Sequencing (WES)
RNA
- RNA-Seq (standard and low input)
- RNA Panel (degraded RNA, focused)
- miRNA Panel
- Single Cell Transcriptomics
- Spatial Transcriptomics
Epigenetics
- Reduced Representation Bisulfite Sequencing (RRBS)
- Assay for Transposase-Accessible Chromatin (ATAC-Seq)
- ChIP-Seq of histone marks
- Cut&Run, Cut&Tag
Customization & Development
- Reverse Phase Protein Array (RPPA)
- Focused Gene Expression/SNP detection (qPCR)
- Custom Next Generation Sequencing
- Custom Bioinformatic Analysis
Mellowes Center Research Facilities & Equipment
Acknowledgement of Mellowes Center Services in Publications and Grant Submissions
Thank you for utilizing Mellowes Center Research Services. Citations and acknowledgements are an essential measurement of how institutional investments produce academic productivity and will support the growth of research services at Mellowes Center and MCW long-term.
'Omics Unit
Unleash the power of state-of-the-art NGS and large-scale assays to uncover the genomic, transcriptomic, epigenomic, and other 'Omic mechanisms fueling cellular processes and disease phenotypes.
Learn more about 'omics services
Bioinformatics Unit
Plunge headfirst into your complex, multi-factorial data using world-class computational infrastructure, backed by a team of highly innovative and collaborative research bioinformatic experts.
Learn more about Bioinformatics services
Research Services
Explore our myriad of standard and cutting-edge services designed to propel your research into the future.
Learn more about Mellowes Center research services
Schedule a Consultation
Embark on your project's journey with a consultation! Let’s meet to explore your research focus and discuss your specific sequencing, high-throughput assay, and analytic needs.
Schedule a consultation with usContact Us
Medical College of Wisconsin
8701 Watertown Plank Rd.
Milwaukee, WI 53226
(414) 955-4887
(414) 955-6516 (fax)
mellowescenterinfo@mcw.edu
