AOIP, Advanced Ocular Imaging Program: Improving Vision Through Advanced Imaging

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Image Gallery

Images are at the heart of our science, and we have selected some of our favorite images to share with you. If you would like a high-resolution version or would like to discuss permission to reproduce, please contact the AOIP via email.

gallery

Albinism hypoplasia OCT

OCT image through the central retina of a patient with X-linked ocular albinism, illustrating the absence of a foveal pit (foveal hypoplasia)

AO flood voronoi

Image of the human cone mosaic, with the Voronoi domain of each cone superimposed. Voronoi analyses are used to characterize the packing geometry of the cone mosaic.

AOSLO fovea periphery

Imaging the smallest cells in the living human retina. The top images are of the cones at the center of the fovea, while the bottom images are of the peripheral retina (small cells are rods, larger cells are cones). The left panels show the images in a linear display, while the right panels show the images in a logarithmic display.

AOSLO peripheral mosaic

Image of the peripheral photoreceptor mosaic. This image was generated by registering and averaging images taken over a span of 2 hours to generate a more uniform appearance of the rods (small cells) and cones (larger cells).

AOSLO Retinitis Pigmentosa fovealcone magnified

Magnified image of the central foveal cone mosaic in a patient with retinitis pigmentosa (RP). Consistent with the preservation of foveal vision in these patients, the cone mosaic appears normal.

Apodized Rods and Cones

An image of cone and rod photoreceptors taken with and without a technique demonstrated by Yusufu Sulai and Alfredo Dubra to enhance the contrast of rod photoreceptors. [PDF]

Basal Laminar Drusen fluorescein angiography

Fluorescein angiography image of a patient with basal laminar drusen.

Best's Disease AOSLO image with lesion

Montage of the photoreceptor mosaic in a patient with Best's disease, obtained with an adaptive optics scanning light ophthalmoscope. The large dark area in the center of the image represents an elevated lesion - this likely disrupts the normal waveguiding of the cone cells making them difficult to resolve in this image.

Best's Disease Color Fundus

Color fundus image from a patient with Best's disease, showing the classic "egg-yolk" lesion.

Best's Disease OCT fovea

OCT image through the fovea in a patient with Best's disease, allowing visualization of the extent of the elevated lesion.

Choroideremia carrier FAF Optos

Wide-field autofluorescence image from a female carrier of choroideremia obtained using the Optos imaging system.

Choroideremia carrier FAF Spectralis

Fundus autofluorescence image from a female carrier of choroideremia obtained using the Spectralis imaging system.

Choroideremia FAF

Fundus autofluorescence image from a patient with choroideremia obtained using the Spectralis imaging system. Bright areas indicate presence of intact RPE cells, whereas the dark area is more severely degenerated retina.

Choroideremia OCT ORT

Volume intensity projection (VIP) image from a patient with advanced choroideremia, with corresponding horizontal and vertical OCT B-scans. The tubules visible in the individual B-scans can be seen as being connected in the VIP image. The VIP image was created by summing the pixels within the outer nuclear layer and photoreceptor layer.

Drusen multimodal imaging

Multimodal imaging - top left is a magnified fundus autofluorescence image, top right is the corresponding image of the photoreceptor mosaic, allowing visualization of the cells immediately overlying the druse. Bottom image is an OCT B-scan of the same druse, allowing for a more in-depth evaluation of the structure.

Drusen OCT

High-resolution Bioptigen OCT image from a patient with multiple large drusen.

Fluorescein Angiography AOSLO Normal

Fluorescein angiography image obtained using an adaptive optics scanning light ophthalmoscope, courtesy of Dr. Richard Rosen, New York Eye & Ear Infirmary.

Fovea variation OCT

OCT B-scans (left) and topographical thickness maps (right) showing the normal variability in the size and shape of the foveal pit.

LIAVA AOSLO

Image of the parafoveal photoreceptor mosaic in a patient with red-green color blindness due to a specific mutation in the L/M opsin genes (LIAVA). The dark gaps represent non-waveguiding cones, presumably the ones expressing the mutant opsin gene.

MacHole postop OCT

OCT B-scan from a patient 9 months following successful macular hole surgery.

Normal vessels, retinal function imager (RFI)

Retinal vascular map obtained from the retinal function imager (RFI) from a healthy retina. Such images normally require a dye, however this image used a motion contrast enhancement technique to visualize perfused capillaries.

Retinitis Pigmentosa (RP) CME OCT

Bioptigen OCT image showing CME in a patient with retinitis pigmentosa (RP).

Retinitis Pigmentosa Adaptive Optics

The bubbled appearance of the top image (AO image of the photoreceptor mosaic) is caused by the presence of numerous cystic structures in the inner retina (seen in the lower OCT image). These structures cast shadows on the underlying photoreceptor layer, which correspond to the dark rings in the AO image.