Images are at the heart of our science, and we have selected some of our favorite images to share with you. If you would like a high-resolution version or would like to discuss permission to reproduce, please contact the AOIP via email.
OCT image through the central retina of a patient with X-linked ocular albinism, illustrating the absence of a foveal pit (foveal hypoplasia)
Image of the human cone mosaic, with the Voronoi domain of each cone superimposed. Voronoi analyses are used to characterize the packing geometry of the cone mosaic.
Imaging the smallest cells in the living human retina. The top images are of the cones at the center of the fovea, while the bottom images are of the peripheral retina (small cells are rods, larger cells are cones). The left panels show the images in a linear display, while the right panels show the images in a logarithmic display.
Image of the peripheral photoreceptor mosaic. This image was generated by registering and averaging images taken over a span of 2 hours to generate a more uniform appearance of the rods (small cells) and cones (larger cells).
Magnified image of the central foveal cone mosaic in a patient with retinitis pigmentosa (RP). Consistent with the preservation of foveal vision in these patients, the cone mosaic appears normal.
An image of cone and rod photoreceptors taken with and without a technique demonstrated by Yusufu Sulai and Alfredo Dubra to enhance the contrast of rod photoreceptors. [PDF]
Fluorescein angiography image of a patient with basal laminar drusen.
Montage of the photoreceptor mosaic in a patient with Best's disease, obtained with an adaptive optics scanning light ophthalmoscope. The large dark area in the center of the image represents an elevated lesion - this likely disrupts the normal waveguiding of the cone cells making them difficult to resolve in this image.
Color fundus image from a patient with Best's disease, showing the classic "egg-yolk" lesion.
OCT image through the fovea in a patient with Best's disease, allowing visualization of the extent of the elevated lesion.
Wide-field autofluorescence image from a female carrier of choroideremia obtained using the Optos imaging system.
Fundus autofluorescence image from a female carrier of choroideremia obtained using the Spectralis imaging system.
Fundus autofluorescence image from a patient with choroideremia obtained using the Spectralis imaging system. Bright areas indicate presence of intact RPE cells, whereas the dark area is more severely degenerated retina.
Volume intensity projection (VIP) image from a patient with advanced choroideremia, with corresponding horizontal and vertical OCT B-scans. The tubules visible in the individual B-scans can be seen as being connected in the VIP image. The VIP image was created by summing the pixels within the outer nuclear layer and photoreceptor layer.
Multimodal imaging - top left is a magnified fundus autofluorescence image, top right is the corresponding image of the photoreceptor mosaic, allowing visualization of the cells immediately overlying the druse. Bottom image is an OCT B-scan of the same druse, allowing for a more in-depth evaluation of the structure.
High-resolution Bioptigen OCT image from a patient with multiple large drusen.
Fluorescein angiography image obtained using an adaptive optics scanning light ophthalmoscope, courtesy of Dr. Richard Rosen, New York Eye & Ear Infirmary.
OCT B-scans (left) and topographical thickness maps (right) showing the normal variability in the size and shape of the foveal pit.
Image of the parafoveal photoreceptor mosaic in a patient with red-green color blindness due to a specific mutation in the L/M opsin genes (LIAVA). The dark gaps represent non-waveguiding cones, presumably the ones expressing the mutant opsin gene.
OCT B-scan from a patient 9 months following successful macular hole surgery.
Retinal vascular map obtained from the retinal function imager (RFI) from a healthy retina. Such images normally require a dye, however this image used a motion contrast enhancement technique to visualize perfused capillaries.
Bioptigen OCT image showing CME in a patient with retinitis pigmentosa (RP).
The bubbled appearance of the top image (AO image of the photoreceptor
mosaic) is caused by the presence of numerous cystic structures in the inner
retina (seen in the lower OCT image). These structures cast shadows on the underlying photoreceptor
layer, which correspond to the dark rings in the AO image.
Wide-field autofluorescence image from a patient with retinitis pigmentosa obtained using the Optos imaging system.
Wide-field fundus image from a patient with retinitis pigmentosa obtained using the Optos imaging system.
Advanced Ocular Imaging Program
925 North 87th Street
Milwaukee, WI 53226
Phone: 414-955-AOIP (2647)