Currently Enrolling Study

Advanced Ocular Imaging: Best Disease

Purpose of study:

This research study is being conducted to understand retinal structure in individuals with Best disease.

What is Best disease?

Best disease is an early onset macular dystrophy, also referred to as a vitelliform dystrophy. It causes a fatty yellow pigment (lipofuscin) to form in the macula, the area of central vision. Over time, these deposits can damage the cells needed for clear central vision.

What is involved in our research?

This non-invasive imaging study may include one or more visits to the Eye Institute. Research volunteers will be asked to complete an ocular health questionnaire and a series of vision tests, and may be asked to give a blood sample to test for the mutations that cause Best disease. In addition, we will use various imaging devices to take pictures of the eye – including optical coherence tomography (OCT), fundus photography, and adaptive optics retinal imaging. At least one eye will be dilated during the visit. There is no direct health benefit to volunteers. Each visit typically takes about 3 hours.


Research volunteers will receive $15 per hour for their time.

You may be eligible to participate in this study if you meet these criteria.
  1. You are at least 5 years old.
  2. A doctor has told you that you have Best disease.
  3. You are willing and able to provide informed consent.
  4. Your vision is better than 20/200 in at least one eye.

More Information:

For additional information about what is involved during an AOIP imaging study click here.



IRB Approval:  PRO00017439, 5/28/2013

Advanced Ocular Imaging Program
Medical College of Wisconsin Eye Institute
925 North 87th Street
Milwaukee, WI 53226
Phone: 414-955-AOIP (2647)
Fax: 414-955-6690
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