Currently Enrolling Study

Advanced Ocular Imaging: Choroideremia

Purpose of study:

This research study is being conducted to understand retinal structure and function in individuals with choroideremia and female carriers of choroideremia. 

What is choroideremia?

Choroideremia is an eye disease that affects mostly males (it is an X-linked disease) and is marked by progressive vision loss. It usually starts with loss of night vision in childhood, followed by narrowing of vision and loss of acuity. There is a loss of the cells used for vision and a degeneration of the choroid (the vessel-rich layer that lines the very back of the eye). We hope to better understand choroideremia by taking a closer look at the cells and layers of the retina that are affected.

What is involved in our research?

This non-invasive imaging study may include one or more visits to the Eye Institute. Research volunteers will be asked to complete an ocular health questionnaire and a series of vision tests, and may be asked to give a blood sample to test for the mutations that cause choroideremia. In addition, we will use various imaging devices to take pictures of the eye – including optical coherence tomography (OCT), fundus photography, and adaptive optics retinal imaging. At least one eye will be dilated during the visit. There is no direct health benefit to volunteers. Each visit typically takes about 3 hours.


Research volunteers will receive $15 per hour for their time.

You may be eligible to participate in this study if you meet these criteria.
  1. You are at least 5 years old.
  2. A doctor has told you that you have choroideremia or you are a female that has a father or son affected with choroideremia.
  3. You are willing and able to provide informed consent.
  4. Your vision is better than 20/200 in at least one eye.

More Information:

For additional information about what is involved during an AOIP imaging study click here.



IRB Approval:  PRO00017439, 5/28/2013

Advanced Ocular Imaging Program
Medical College of Wisconsin Eye Institute
925 North 87th Street
Milwaukee, WI 53226
Phone: 414-955-AOIP (2647)
Fax: 414-955-6690
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