Adult Echocardiography Core Laboratory

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Aortic Valve Insufficiency Aortic Valve Insufficiency 3D Aortic Valve Insufficiency

Services:

Comprehensive Screening Echocardiogram

Serial Screening Echocardiogram

Limited 2D Echocardiogram for Left Ventricle Function

Saline Contrast Echocardiogram

Trans-pulmonary Contrast Studies for Myocardial Perfusion or Function

Carotid Intima-Media Thickness (CIMT)

Customized Echocardiography

Strain/Strain Rate Analysis of Left Ventricle


Exam Details:

Comprehensive Screening Echocardiogram: Non-invasive transthoracic cardiac ultrasound exam that includes 2D, pulse-wave Doppler, continuous-wave Doppler, color Doppler and tissue Doppler imaging.  The Adult Core Lab follows the American Society of Echocardiography Guidelines for performance of a comprehensive transthoracic echocardiography examination including chamber quantification, Doppler echocardiography, valve hemodynamics and diastolic function.

Data provided at the study end: Comprehensive echocardiogram report with multiple echo parameters including:

• Demographic information
• Systolic  function
• Evaluation of cardiac structures
• Diastolic function
• LV size and volume in end-systole                  and end-diastole
• Valve morphology and hemodynamics
• Wall thickness and mass
• Chamber quantification
•RV size and function
• Wall motion analysis

 

Serial Screening Echocardiogram: Echocardiograms that must occur within specific windows and must be repeated on the subject at a specific later date. Includes all the analysis of a screening echocardiogram at each echo date.

Limited 2D Echocardiogram for Left Ventricle Function: When the echo protocol specifies left ventricle ejection fraction only, a limited study may be performed.  Valve hemodynamics and diastolic function are not included in a limited 2D study.

Data provided at the study end: Echo report with demographic information, evaluation of cardiac structures, chamber sizes, left ventricle ejection fraction, wall thickness, left ventricle end-diastolic and end-systolic volumes, and valve morphology.

Saline Contrast Echocardiogram: Saline contrast echocardiography is a reliable non-invasive method for detection of intra-atrial or pulmonary right-to-left shunting.  This study may be added to either a Screening Echocardiogram or a Limited 2D Echocardiogram.  For subject safety, a Limited 2D echocardiogram is required prior to administration of agitated saline.

Data provided at the study end: Echo report with demographic information, evaluation of cardiac structures, chamber sizes, left ventricle ejection fraction, wall thickness, left ventricle end-diastolic and end-systolic volumes, valve morphology and if detected, quantification of right-to-left shunting following resting saline contrast injection and injection with Valsalva maneuver.

Trans-pulmonary Contrast Studies for Myocardial Perfusion or Function: Trans-pulmonary contrast agents traverse the pulmonary capillary bed to opacify the left ventricle and enable segmental wall motion analysis or quantify myocardial perfusion of LV segments.

Data provided at the study end: Echo report with demographic information, evaluation of cardiac structures, chamber sizes, left ventricle ejection fraction, wall thickness, left ventricle end-diastolic and end-systolic volumes, valve morphology. Trans-pulmonary contrast studies may be combined with either a Screening Echocardiogram or Limited 2D Study.  For subject safety, a Limited 2D Echocardiogram is required prior to administration of contrast agents.

Carotid Intima-Media Thickness (IMT): Ultrasound scanning is used to delineate the carotid artery.  A dedicated IMT quantification program is utilized for quantitative analysis of the IMT. 

Data provided at the study end: Customized depending upon discussion with PI.

Customized Echocardiography: Includes studies that the core staff and the PI have discussed in detail and that are not offered on a routine basis.  Analysis and data reporting will be included.

Data provided at the study end: Customized depending upon discussion with PI.

Strain Analysis of Left Ventricle: 2D speckle tracking echocardiography is a novel technique that enables the assessment of myocardial strain through the analysis of speckle motion inherently present in a standard, 2D echocardiographic image. This technique is angle independent and preload independent. It is not affected by tethering between segments and less operator dependent. This technique has been validated in experimental and human studies and found to correspond well to established “gold standard” techniques.

  Why use strain imaging for your study:

  • Strain has increased sensitivity in detecting LV systolic dysfunction when compared to conventional LV function analysis (i.e. ejection fraction and fractional shortening)

  • Strain analysis is better suited for regional wall motion abnormalities

  • Speckle tracking-derived strain correlates with the degree of cardiac fibrosis

  Data provided at the study end: Spreadsheet with quantitative regional and global strain values.

 Strain Rate Analysis of Left Ventricle:

  Why analyze strain rate for your study:

  • Diastolic strain rate may be used as an additional surrogate of ventricular fibrosis and segmental relaxation abnormalities.

  • By providing insight into regional diastolic function, segmental diastolic strain rate can readily uncover the presence and extent of regional ischemia and viability.

Data provided at the study end: Spreadsheet with quantitative regional and global strain rate values.

 
Doppler Analysis of Diastolic Function, Transvalvular Velocities and Valve Regurgitation:  We routinely assess LV diastolic function based on Doppler-derived parameters: E/e', E/A, Vp, and IVRT/RR. Doppler is also used to assess transvalvular velocities and regurgitant lesions. We can use Doppler measurements to quantify the severity of obstructive or regurgitant valve lesions.

 

 

 

 

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Page Updated 11/14/2013