Anthony Hudetz, DBM, PhDAnthony Hudetz, DBM, PhD

Professor of Anesthesiology, Physiology and Biophysics

Medical College of Wisconsin
Anesthesiology Research
8701 Watertown Plank Road
Milwaukee, WI 53226-0509
(414) 955-5622
(414) 955-6507 (fax)

Dr. Hudetz graduated from the Eötvös Loránd University, Budapest, Hungary in 1974 with a MS degree in physics. He received Doctor of Biologiae Medicinalis (DBM) degree from the Semmelweis University of Medicine, Budapest, Hungary in 1979. He obtained PhD degree from the Hungarian Academy of Qualifications in 1985. Dr. Hudetz held faculty appointments in the 2nd Department of Physiology, Semmelweis University of Medicine, in the Department of Biomedical Engineering, Louisiana Tech University and in the Department of Physiology and subsequently, in the Department of Anesthesiology at the Medical College of Wisconsin. He is also Adjunct Professor in the Department of Biomedical Engineering, Marquette University. While at MCW, he rose to the rank of professor in 1998 and received Tenure in the Department of Anesthesiology in 2007. Dr. Hudetz is the recipient of the first Melvin H. Knisely Award from the International Society of Oxygen Transport to Tissue and a Research Award from the Hungarian Physiological Society. He is past president of International Society of Oxygen Transport to Tissue. He has published over 100 articles and has maintained NIH funding since 1997.

Dr. Hudetz’s current research interest is in discovering the mechanisms by which anesthetics produce loss of consciousness. Does consciousness really disappear when the patient is not responding? What happens to the thinking brain when it is anesthetized?

Dr. Hudetz’s research team investigates the electrophysiological changes that occur in a rat brain that has been subjected to varying depths of anesthesia with various volatile and intravenous agents. They apply advanced signal analysis tools to determine the complex spatial and temporal behavior of intracortical potentials in the anesthetized brain. They use pharmacological tools to modulate the effects of anesthetic agents in order to better understand the underlying cellular mechanisms.

They also perform functional magnetic resonance imaging (fMRI) of the rat brain to determine the neurofunctional networks that anesthetic agents primarily target. One of the important findings is that the anesthetized brain retains much of its reactive capability to sensory stimuli. However, the cortical responses evoked by these stimuli are not interpreted at the conscious level due to a disruption of information integration in large-scale neuronal networks. The significance of this research is that it should lead to a better understanding of anesthetic mechanisms in the brain, aid the design of more specific, safer anesthetic agents and the development of novel techniques based on brain neurophysiology to monitor the depth of anesthesia.

To contact Dr. Hudetz, please call (414) 955-5622 or e-mail to

Recent Publications

Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53226
(414) 955-8296
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