David F. Stowe, MD, PhD
Professor of Anesthesiology and Physiology
Adjunct Professor of Biomedical Engineering
Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53226-0509
(414) 955-5722 | (414) 955-6507 (fax) | firstname.lastname@example.org
Faculty Collaboration Database Profile
Dr. David Stowe received his PhD degree from Michigan State University and his MD degree from the Medical College of Wisconsin. He completed a Postdoctoral Fellowship at the Cardiovascular Research Institute at the University of California - San Francisco. His residency training was completed in the Department of Anesthesiology at the Medical College of Wisconsin. Dr. Stowe spends his time approximately 50:50 clinical: research.
Dr. Stowe has long conducted research on how to protect the heart against ischemia reperfusion injury. This includes the effects of age, hypothermia, ischemic and pharmacologic preconditioning (volatile anesthetics, adenosine, other cardiotonic agents), sodium hydrogen and sodium calcium exchange inhibitors, and cardioplegic formulations on electrophysiology, contractility, vascular reactivity, reactive species formation, ion fluxes, metabolism and tissue damage. More recently, Dr. Stowe's laboratory has emphasized investigation into the role of the mitochondrial damage in contributing to cardiac ischemia reperfusion damage. These include assessment of mitochondrial bioenergetics (respiration, inner membrane potential, redox potential, hydrogen, potassium and calcium fluxes, and reactive oxygen and nitrogen species) by drugs, hypothermia, ischemia reperfusion injury in isolated and in vivo hearts, isolated cardiac cells, and isolated mitochondria. A newer, special interest of the lab is characterization and function of the mitochondrial calcium-sensitive, small conductance potassium channel (SK), which was first discovered in Dr. Stowe’s lab in the mitochondria of rat, guinea pig and human cardiac myocytes. This project, currently funded by a four year VA Merit grant, will examine the splice variant of the SK channel and the effects of SK channel knockout and knockins on mitochondrial and myocardial function with ischemic stress.
Dr. Stowe has till now mentored 14 pre-doctoral research students, 25 post-doctoral research trainees, 28 medical students in research, and 21 undergraduates in research. He has received 45 grants and contracts over time to pursue his research interests and he has published currently 16 book chapters, 15 research review articles, and over 150 original research articles.