Zhi-Dong Ge, MD, PhD
Assistant Professor of Anesthesiology
Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53226-0509
(414) 955-6507 (fax)
Dr. Ge received his PhD from the University of Hong Kong and his MD from Anhui Medical College in China. He completed a Fellowship and a Postdoctoral Fellowship with the Department of Pharmacology and Toxicology at the Medical College of Wisconsin.
Dr. Ge’s research focuses on protection of ischemic myocardium against ischemia and reperfusion injury. This includes the application of volatile anesthetics, adenosine receptor agonists, and ischemic preconditioning, the phenomenon in which myocardium exposed to brief, repeated periods of sublethal ischemia becomes resistant to the deleterious effects of ischemia or reperfusion. Recent evidence from this research indicates that genetic modulation of GTP cyclohydrolase 1 to increase cardiac tetrahydrobiopterin and nitric oxide production can protect myocardium from ischemia and reperfusion injury and preserve the ability of ischemic preconditioning to elicit cardioprotection that is impaired by hyperglycemia. Further investigations are being actively conducted, including the mechanisms underlying myocardial protection by overexpression of GTP cyclohydrolase 1 gene in the presence of hyperglycemia and diabetes, and the potential of GTP cyclohydrolase 1 overexpression in reducing maladaptive myocardial remodeling following infarction in diabetic and non-diabetic myocardium.
To contact Dr. Ge, please call (414) 955-5805 or e-mail firstname.lastname@example.org.