Aberrant activation of the Raf/MEK/ERK pathway is a central feature in many cancers but, paradoxically, sustained activation of the pathway induces cell cycle arrest and senescence as a primary response in normal cells. This response is recognized as a tumor suppressive mechanism that needs to be disabled or bypassed for tumor progression. Our understanding of how MEK/ERK signaling molecules controls this key event in carcinogenesis is currently limited. My work aims to decipher the ERK1/2 signaling network and its growth-arrest specific effectors using biochemistry and proteomics techniques. This study will enable us to further address the mechanism that underlies Raf/MEK/ERK carcinogenesis.
Involvement of protein kinase C and E2F-5 in euxanthone-induced neurite differentiation of neuroblastoma. HaWY, Wu PK, Kok TW, Leung KW, Mak NK, Yue PYK, Ngai SM, Tsai SN, Wong RNS. International Journal of Biochemistry and Cell Biology. 2006Mar, 38(8):1393-401.
The angiosuppressive effects of 20(R)-ginsenoside Rg3. Yue PY, Wong DY, Wu PK, Leung PY, Mak NK, Yeung HW, Liu L, Cai Z, Jiang ZH, Fan TP, Wong RN. Biochemical Pharmacology. 2006Aug, 72(4):437-45.
Oleanolic acid isolated from Oldenlandia diffusa exhibits a unique growth inhibitory effect against ras-transformed fibroblasts. Wu PK, Tai WCS, Liang ZT, Zha oZZ, Hsiao WLW. Life Sciences. 2009Jul, 85(3-4):113-21.
Chemical and DNA authentication of taste variants of Gynostemma pentaphyllum herbal tea. Wu PK, Tai WCS, Choi RCY, Tsim KWK, Zhou H, Liu X, Jiang ZH, Hsiao WLW. Food Chemistry. Volume: 128, Issue: 1, Publisher: ELSEVIER SCI LTD, Pages: 70-80