MCW Cardiovascular Center Affiliated Faculty

 A - D

Aufderheide, Tom P., MD
Professor, Emergency Medicine
(414) 805-6717 |
 ► Dr. Tom Aufderheide is a Professor of Emergency Medicine with Tenure and Associate Chair of Research Affairs and Director of the NIH-funded Resuscitation Research Center in the Department of Emergency Medicine at the Medical College of Wisconsin. He is a nationally and internationally recognized researcher in the field of emergency cardiac care. Recent Publications.

Avner, Ellis, MD
Professor, Medicine/Pediatric Nephrology
Director, Children’s Research Institute
(414) 955-2573 |
 ► Basic cellular and molecular pathophysiology of polycystic kidney disease and it’s complications, which include hypertension, heart failure, and stroke. Goal is to identify the basic cellular abnormalities of the polycystic endothelial and epithelial cell, and target such abnormalities with specific pharmacological inhibitors, with the ultimate goal of preventing disease progression and the development of complications. Recent Publications.

Baker, John E., PhD, FAHA
Professor, Surgery/Cardiothoracic
Professor, Pharmacology and Toxicology
Professor, Biochemistry
Investigator, Children's Research Institute

(414) 955-8706 |
 ► Basic research on cardiovascular development and causes of cardiovascular diseases. Translational research to improve clinical outcomes following cardiac surgery. Protection of the child’s cardiovascular system against injury from radiation. Recent Publications.

Bienengraeber, Martin, PhD
Assistant Professor, Anesthesiology
Assistant Professor, Pharmacology and Toxicology

(414) 955-5690 |
 ► One of my research interests revolves around the role of mitochondria as triggers and effectors in protection of the heart from ischemia and stress. We use physiological, pharmacological and molecular techniques as well as proteomics to demonstrate quantifiable alterations in mitochondrial bioenergetics and protein expression during or after exposure to volatile anesthetics. Recent Publications.

Bosnjak, Zeljko J., PhD
Professor, Anesthesiology
(414) 955-5687 |
 ► Cellular mechanisms of anesthetic action. Cellular signal transduction pathways responsible for anesthetic-induced cardioprotection and the modulation of ATP sensitive potassium current in cardiac myocytes by ischemia and volatile anesthetics. Genetic basis for differences in anesthetic response and neuropathy and calcium signaling. Recent Publications.

Broeckel, Ulrich, MD
Chief and Associate Professor, Pediatrics/Genomic Pediatrics
(414) 955-2369 |
 ► The Broeckel lab focuses on the identification and functional evaluation of genes involved in cardiovascular diseases. We have an ongoing research project focused on left ventricular hypertrophy, myocardial infarction and coronary artery disease, end-stage renal disease, and hypertension. Recent Publications.

Camara, Amadou K.S., PhD
Associate Professor, Anesthesiology
(414) 955-5624 |
 ► Dr. Camara's recent research interests focus on the role of mitochondria (respiration, inner membrane potential, redox potential, reactive oxygen species) in cardiac preservation during hypothermic and normothermic ischemia and reperfusion in isolated cardiac cells. Recent Publications.

Campbell, William B., PhD
Professor and Chairman, Pharmacology and Toxicology/Cardiovascular Pharmacology

(414) 955-8267 |
 ► Research in our laboratory involves the isolation and identification of new metabolites of arachidonic acid and other endothelial mediators of vascular function. Recent Publications.

Cinquegrani, Michael P., MD, FACC, FSCAI
Interim Chief of Cardiovascular Medicine
Professor, Cardiovascular Medicine

(955) 456-6737 |
 ► Dr. Cinquegrani has been a member of the faculty since completing his Cardiology Fellowship in 1985 at the University of Rochester Medical Center. His principal clinical activities relate to interventional and invasive cardiology and the evaluation and treatment of patients with heart failure. Dr. Cinquegrani also has held a number of administrative positions including Interim Chief of Cardiology, Director of Cardiac Catheterization, and Director of Cardiology Fellowship Training.

Cohen, Eric P., MD
Professor, Medicine/Nephrology
Zablocki VA Hospital
(414) 384-2000, x 42825 |
 ► My research is centered around radiation nephropathy, experimental and clinical. This occurs in humans after radiation-based bone marrow transplant and internal radionuclide therapies. It is also a risk of accidental or terrorist radiation exposure. Mitigation of that injury and its mechanism are being tested. Recent Publications.

Corbett, John A., PhD
Chairman and Professor, Biochemistry
(414) 955-8768 |
 ► Our laboratory is focused on determining the factors that influence the function and survival of pancreatic beta cells in the context of both type 1 and type 2 diabetes mellitus. We currently have three ongoing research programs. Recent Publications.

Chrzanowska-Wodnicka, Magdalena, PhD, FAHA
Associate Investigator, Blood Research Institute
(414) 937-3890
 ► My laboratory studies the function of small G proteins in the cardiovascular system. We use transgenic mouse and zebrafish models for in vivo studies and a variety of biochemical, molecular and microscopy approaches to interrogate signaling by small GTPases in vascular cells ex vivo.

Dash, Ranjan K., PhD
Assistant Professor, Biotechnology and Bioengineering
Assistant Professor, Physiology

(414) 955-4497 |
 ► Mathematical modeling and computer simulations of complex physiological systems. Computational algorithms for data analysis and parameter estimation (optimization). Microcirculatory oxygen and carbon dioxide transport and exchange. Multi-scale modeling of coupled blood-tissue solute transport and cellular energy metabolism in cardiac and skeletal muscles. Analysis of large-scale biochemical systems: regulation of cellular energy metabolism and mitochondrial oxygen consumption in cardiac and skeletal muscles. Mitochondrial handling of cations (Ca2+, Na+, K+, H+, Mg2+) and ROS (O2, H2O2). Recent Publications.

Duncan, Stephen A., DPhil
Marcus Professor of Human and Molecular Genetics
Professor, Cell Biology, Neurobiology and Anatomy

(414) 955-8602 |
 ► Molecular mechanisms underlying mammalian development. Recent Publications.

 E - H

El-Meanawy, Ashraf, PhD, MD
Assistant Professor, Medicine/Nephrology  
(414) 407-0104 |
 ► My laboratory is studying the genetic factors contributing to the development of a vulnerable kidney. We are focused on understanding the genes and pathways responsible for reduction in the number of the filtration units "the Nephron" at birth. Subjects borne with such reduced nephron number are at risk for developing hypertension and chronic kidney disease later in life. Recent Publications.

Gebremedhin, Debebe, BPharm, PhD
Associate Professor, Physiology
(414) 955-7515 |
 ► The mission of our laboratory is to understand mechanisms regulating physiology of the cerebral circulation in health and in disease conditions. Our research interests involve functional identification and characterization of different ion channel types and second messenger systems in vascular smooth muscle cells, endothelial cells, neurons and in brain astrocytes. Recent Publications.

Greene, Andrew S., PhD
Dr. Robert D. and Dr. Patricia E. Kern Professor in Biotechnology and Bioengineering
Professor, Physiology
Director, Biotechnology and Bioengineering Center
Director, Kern Innovation Center

(414) 955-8671 |
 ► In a broad sense, our laboratory is attempting to understand fundamental principles of cardiovascular regulation and disease. Our research is highly collaborative and spans the areas of molecular and cellular biology, genetics, proteomics, technology development and microcirculatory experiments. Recent Publications.

Gundry, Rebekah, PhD
Assistant Professor, Biochemistry
(414) 955-2825 |
 ► Dr. Gundry welcomes MCW graduate students interested in studying in the areas of stem cell biology and mass spectrometry. Potential postdoctoral research fellows are also encouraged to communicate their interests. Collaborations with researchers in the areas of cardiac development, pluripotent stem cell biology, and secreted and plasma membrane protein biology are especially welcomed. Recent Publications.

Hoch, Anne, DO
Associate Professor, Orthopaedic Surgery
(414) 805-7461 |
 ► Consequences of athletic amenorrhea in high school and college girls. Prevalence of disordered eating, amenorrhea, osteoporosis and early cardiovascular disease among high school girls – "Female Athlete Tetrad". Recent Publications.

Hogan, Quinn H., MD
Professor, Anesthesiology
(414) 955-5727 |
 ► Cerebral blood flow regulation, microcirculation, oxygen transport, functional hyperemia, and effect of anesthetic agents. Causes of pain. Recent Publications.

 I - L

Jacob, Howard, PhD
Warren P. Knowles Professor and Director of the Human and Molecular Genetics Center
Professor, Physiology
Vice Chairman for Research, Childrens' Hospital of Wisconsin

(414) 955-4887 |
 ► The laboratory specializes in building and implementing genomic "tools" in the whole animal. Our goal is to link genomic tools to physiology for discovering the genetic basis of disease, including end stage renal disease (rat and human), hypertension (rat), insulin dependent diabetes mellitus (rat), syndrome-X (rat), left ventricular hypertrophy, myocardial infarction (rat and human) and various cardiac malformations (human). Recent Publications.

Kalyanaraman, Balaraman, PhD
Chairman and Harry R. & Angeline E. Quadracci Professor in Parkinson's Research, Biophysics
(414) 955-4000 |
 ► Promotes and stimulates free radical research at MCW and helps researchers engaged in free radical research acquire NIH and other extramural funding. Unique because it is closely associated with an EPR research resource (only physical technique that can detect unambiguously free radicals in biological systems) and an MRI facility. Promotes translational research in free radical-mediated diseases at MCW and neighboring institutes and develops therapeutic interventions in free radical based disease processes. Improves the understanding of the mechanism of action of antioxidants (i.e., agents that scavenge or inhibit free radical formation) in human disease. Recent Publications.

Kersten, Judy R., MD
Professor, Pharmacology and Toxicology/Cardiovascular Pharmacology
Department of Anesthesiology

(414) 955-5802 |
 ► Diabetes and hyperglycemia are clear contributors to adverse outcome in patients at risk for myocardial ischemia, but the mechanisms responsible for this observation are poorly understood. Ischemic preconditioning is a powerful endogenous mechanism protecting the myocardium against infarction. Our work indicates that diabetes or hyperglycemia prevents reductions of myocardial infarct size by ischemic preconditioning. Recent Publications.

Kotchen, Theodore, MD
Professor of Medicine, Endocrinology, Metabolism and Clinical Nutrition
Associate Dean for Clinical Research

(414) 805-8696 |
 ► Dr. Kotchen's research interests focus primarily on hypertension, and he is author or co-author of over 200 peer reviewed publications. Most deal with mechanisms of blood pressure control, hypertension treatment strategies, and genes of hypertension. Recent Publications.

Kwok, Wai-Meng, PhD
Professor, Anesthesiology
(414) 955-5683 |
 ► The overall focus of Dr. Kwok’s laboratory is the investigation of ion channel modulation in the heart. There are two major areas of research currently underway. The first major area of investigation is on identifying a volatile anesthetic interaction site on a cardiac potassium channel, IKs, and characterizing the molecular determinants that modulate anesthetic action on this channel. Recent Publications.

Liang, Mingyu, PhD
Associate Professor, Physiology
(414) 955-8539 |
 ► My laboratory's research interest is on understanding and integrating multiple aspects and components of physiology. Our current work is focused on studying renal, cardiovascular, and endocrine physiology and pathophysiology associated with hypertension and diabetes. Recent Publications.

Lombard, Julian H., PhD
Professor, Physiology
(414) 955-8530 |
 ► Current research in this laboratory utilizes television microscopy, optical Doppler velocity measurements, oxygen microelectrodes, electrophysiological techniques and molecular biology to investigate the mechanisms by which changes in oxygen availability regulate active tone in microvessels and small resistance arteries. Recent Publications.

Lough, John, PhD
Professor, Cell Biology, Neurobiology & Anatomy
(414) 955-8459 |
 ► Cell and molecular biology of cardiac stem cell differentiation. Our research is focused on adult cardiac regeneration, using principles learned from previous investigation of heart development in the embryo. We are using two independent albeit complementary approaches to address this problem. Recent Publications.

 M - P

Mattson, David L., PhD
Professor, Physiology
(414) 955-8571 |
 ► Studies in the Mattson laboratory examine the normal and pathophysiological regulation of renal function and arterial blood pressure. A particular emphasis is placed on the paracrine, autocrine, and hormonal regulation of renal tubular and vascular function. Recent Publications.

Misra, Ravi P., PhD
Dean, Graduate School of Biomedical Sciences
Professor, Biochemistry

(414) 955-8433 |
 ► One of the overall objectives of our research is to elucidate underlying molecular mechanisms involved in cardiac function and heart formation. Congenital cardiovascular anomalies are the most common form of human birth defect with a recorded instance of 1 per 200 live births per year in North America. There is, therefore, considerable interest in understanding the molecular and genetic bases of these diseases. Recent Publications.

Mitchell, Michael E., MD
Associate Professor, Surgery/Cardiothoracic Surgery
Specialization: Congenital Heart Disease
(414) 266-2491 |
 ► The genetic and molecular etiology of congenital heart disease. We are interested in identifying genetic risk factors for congenital heart disease. We believe the ability to identify these genetic risk factors will allow us to investigate the relationship between genetic deficits and molecular pathways and clinical variability, in order to make early and accurate diagnosis. The long-term goal for this research is to improve intervention strategies and long-term outcomes for our patients. Recent Publications.

Newman, Debra K., PhD
Associated Adjunct Professor, Pharmacology and Toxicology
Investigator, Blood Research Institute, BloodCenter of Wisconsin

(414) 937-3820
 ► We study the structure and function of Platelet Endothelial Cell Adhesion Molecule (PECAM)-1, also designated CD31. PECAM-1 is a 130 kDa member of the immunoglobulin (Ig) gene superfamily that is expressed on the surfaces of cells found within the vasculature, including the endothelial cells that line blood vessels and the leukocytes (monocytes, neutrophils and certain T-cell subsets) and platelets that circulate within them. Recent Publications.

North, Paula, MD, PhD
Professor and Chief, Pathology
(414) 266-6288 |
 ► Vasculogenesis and hemangioma. Cell/molecular biology of vascular anomalies (developmental/acquired). Recent Publications.

Oldham, Keith T., MD
Professor and Chief, Pediatric Surgery
(414) 266-6550 |
► Acute lung injury, shock, sepsis, pulmonary injury, cardiovascular disease, sickle cell disease, impaired vasodilation. Experimental therapeutic treatment (D-4F) of vascular disease as it relates to heart disease and stroke. Recent Publications.

Patel, Shailendra, MD, PhD
Professor of Medicine, Endocrinology, Metabolism and Clinical Nutrition
Director of Clinical, Research and Educational Efforts for the Division

(414) 955-5645 |
 ► Genetics, physiology and pathophysiology of cholesterol disorders, embryonic development. Recent Publications.

Pfister, Sandra, PhD
Associate Professor, Pharmacology and Toxicology/Cardiovascular Pharmacology
(414) 955-8285 |
 ► Atherosclerosis is a multi-factorial disease involving a number of different cell types and mechanisms. Of particular interest is the evidence that the synthesis of thromboxane, the predominant metabolite of arachidonic acid in platelets, increases in atherosclerosis and blockade of thromboxane receptors attenuates atherosclerotic plaque formation in mice and rabbits. The current therapeutic strategy of low dose aspirin to protect against cardiovascular disease provides further evidence that thromboxane is an important component of the vascular responses in atherosclerosis since this regimen is designed to selectively inhibit platelet thromboxane production. Despite this, the exact role of thromboxane in the development and progression of atherosclerosis is not well understood. Recent Publications.

Pritchard, Jr., Kirkwood A., PhD
Professor, Surgery/Pediatrics Surgery
Vice Chair, Research

(414) 955-5615 |
 ► Acute lung injury, shock, sepsis, pulmonary injury, cardiovascular disease, sickle cell disease, impaired vasodilation. Experimental therapeutic treatment (D-4F) of vascular disease as it relates to heart disease and stroke. Endothelial and cardiac cell biology, nitric oxide, molecular mechanisms of free radical generation, adenoviral gene transfer technology. Recent Publications.

 Q - T

Ramchandran, Ramani, PhD
Associate Professor, Pediatrics/Genetics
(414) 955-2387 |
 ► Axon guidance, hemangiomas of infancy, vascular biology, Zebrafish. Recent Publications.

Regner, Kevin, MD, PhD
Assistant Professor, Medicine/Nephrology
(414) 805-9050 |
 ► My laboratory is interested in studying the effects of ischemic acute kidney injury (AKI). We are collaborating with other KDC investigators on the following projects: 1) Evaluation of the protective effect of synthetic 20-HETE analogues in ischemic kidney injury. The long term goal of this research is to develop new therapies to prevent or treat AKI based on an understanding of the genetic, physiologic, and molecular mechanisms that underlie the effects of 20-HETE in ischemic kidney injury. 2) Evaluation of the long term effects of acute renal ischemia by utilizing genetic models of diabetes and hypertension that recapitulate the physiologic milieu in humans that increases susceptibility to AKI. Recent Publications.

Sorokin, Andrey, PhD
Associate Professor, Medicine/Nephrology
(414) 955-4438 |
 ► Understanding the details of signaling pathways leading from G-protein coupled receptors and tyrosine kinases through adaptor proteins to downstream signaling molecules. Investigation of the Cox-2-dependent molecular mechanisms of resistance of cells to apoptosis. Recent Publications.

Starushchenko, Alexander, PhD
Assistant Professor, Physiology
(414) 955-8475 |
 ► We are interested in the normal and pathophysiological regulation of epithelial ion channels. A particular emphasis is placed on the epithelial Na+ channel (ENaC). The long term control of blood pressure involves Na+ homeostasis through the precise regulation of ENaC in the aldosterone-sensitive distal nephron. Recent Publications.

Stowe, David F., MD, PhD
Professor, Anesthesiology/Clinical
(414) 955-5722 |
 ► Role of mitochondrial bioenergetics, NADH levels and ATP synthesis. Mechanisms of injury to the heart when its blood supply is interrupted. Mechanisms of preservation during cold storage as in heart transplantation. Effects of drugs and preservation agents to protect the heart against ischemic damage. Recent Publications.

Tabatabai, Niloofar, PhD
Assistant Professor, Medicine/Endocrinology, Metabolism and Clinical Nutrition
(414) 955-8452 |
 ► I study the molecular expression and regulation of the kidney sodium-glucose cotransporters (SGLTs). Recent Publications.

Tomita-Mitchell, Aoy, PhD
Assistant Professor, Surgery/Cardiothoracic Pediatrics
(414) 955-4531 |
 ► We are interested in identifying genetic risk factors for congenital heart disease. We believe the ability to identify these genetic risk factors will allow us to investigate the relationship between genetic deficits and molecular pathways and clinical variability, in order to make early and accurate diagnosis. The long-term goal for this research is to improve intervention strategies and long-term outcomes for our patients. Recent Publications.

 U - Z

Van Why, Scott, MD
Associate Professor, Pediatrics/Nephrology
(414) 337-7140 |
 ► Acute renal failure remains a major medical problem that contributes to high patient morbidity and associated mortality of greater than 50%. My laboratory is exploring the genetic basis for resistance or susceptibility to develop renal failure after ischemic injury to the kidney. Recent Publications.

Warltier, David C., MD, PhD
Chairman and Professor, Anesthesiology
(414) 805-8703 |
 ► Cardiovascular physiology and pharmacology with special emphasis on angiogenesis in the coronary circulation and pharmacological cardioprotection against myocardial infarction. Recent Publications.

Wilkinson, George A., PhD
Assistant Professor, Pediatrics
Investigator, Children's Research Institute

(414) 955-2389
 ► Angiogenesis, developmental biology, mouse genetics, signal transduction.

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