Cardiovascular Center

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High Dose Atorvastatin Reduces Periodontal Inflammation: A Novel Pleiotropic Effect of Statins

Cardiovascular Medicine Fellow, Dr. Sharath Subramanian, has been recently published in the Journal of the American College of Cardiology.  This article explores whether high-dose statin treatment results in a reduction in periodontal inflammation. 

 Article (link)

Statins May Be Linked To Reduced Risk Of Periodontitis.

The New York Times (10/3, Bakalar, 9.61M) “Well” blog reports that research published online in the Journal of the American College of Cardiology suggests that statin use may be linked to a reduced risk of periodontitis. Investigators “assigned 83 people with heart disease or at high risk for heart disease to take a daily dose of either 80 milligrams or 10 milligrams of atorvastatin (both Lipitor and generics) for” about three months. Physicians then “used CT and PET scans to evaluate them for periodontal disease and arterial inflammation at the start of the study and again at the end.”

Forbes (10/3, 6.03M) contributor Larry Husten writes that the researchers found “a significant reduction in periodontal inflammation as measured by PET in patients taking high dose atorvastatin.” The investigators found that “the effect was greatest in those patients who had active periodontal disease.”

CardioSource (10/3, 2K) reports that lead author Sharath Subramanian, MD, said, “These results identify a potentially novel pleiotropic effect of statins and raise the possibility that an indirect benefit of statins on atherosclerosis may in part relate to a reduction in extra-arterial inflammation.” HealthDay (10/3, Gordon, 5K) also covers the story. To view the full JACC article, click here.
© 2014 Medical College of Wisconsin
Page Updated 06/18/2014