Cardiovascular Center

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The Gutterman Lab Members


David Gutterman, MD
Principal Investigator

Dr. Gutterman is the Northwestern Mutual Professor of Cardiology. He is actively involved  in clinical practice, supervises a NIH funded research laboratory and provides senior administrative oversight of research administration at the Medical College of Wisconsin. He has served in a leadership role in a variety of national and international cardiovascular scientific organizations.




Joe Hockenberry
Research Technologist II

Within Dr. Gutterman’s lab my primary role is to collect and analyze experimental data for multiple research projects and to provide support where needed to meet the goals of the laboratory faculty. I have background in cell biology and regenerative medicine and an interest in genetics and physiology.


Julie Freed, MD, PhD

Within the theme of the Gutterman lab, my interests include understanding the role of the endothelium in vascular health and disease. My current research looks into how biologically active lipids, specifically sphingolipids which are known to be elevated in patients with coronary artery disease, can signal to the mitochondria and alter the mediator of flow-mediated dilation from nitric oxide to hydrogen peroxide.  I have also recently become interested in the role of endothelial microparticles in vascular dysfunction.

Ryan Nord
Research Technologist I

Dr. David Gutterman’s lab uses discarded surgical tissue for functional vessel studies and I am in charge of all the tissue collection related to this research and maintain a database of all the samples collected. I also make various solutions used in these studies and perform many general lab tasks to help the other lab members meet their research goals.

Matt Durand, PhD

My research interests examine how acute and chronic stress can alter human vascular function.  Using isolated human adipose arterioles, we have shown that increasing intraluminal pressure within the vessel can acutely impair vasodilator responses to acetylcholine and shear stress.  This impairment can be reversed in the presence of renin-angiotensin system inhibitors, suggesting that the vascular renin-angiotensin system plays a role in this response.  Another study I’m involved with is a collaboration with Marquette University, which examines differential responses to exercise in the femoral artery of people who have suffered a hemiparetic stroke.  Preliminary data from this study suggests that decreased blood flow to the paretic leg contributes to baseline muscle weakness and increased neuromuscular fatigability in these individuals.                             

Natalya Zinkevich, PhD
Research Scientist I

My research interests are related to vascular health and disease. Specifically, I am interested in the role of endothelial cells in mediating vasodilation. Within this broad topic, I address three questions:

a) How do the mechanisms of endothelium-dependent dilation change during aging and with the onset of coronary artery disease?

b) What is the role of cellular enzymatic sources of reactive oxygen species in this process?

c) How does the transient receptor potential vanilloid 4 (TRPV4) channel superfamily contributes to vasorelaxation?                  
© 2014 Medical College of Wisconsin
Page Updated 06/18/2014