David X. Zhang, PhD
The overall emphasis of Dr. David X. Zhang's research is to understand the cellular mechanisms by which the endothelium regulates blood vessel tone in both normal physiological conditions and disease states, such as ischemic heart disease and hypertension.
Natalya Zinkevich, PhD
Research Scientist I
My research interests are related to vascular health and disease. Specifically, I am interested in the role of endothelial cells in mediating vasodilation. Within this broad topic, I address three questions:
a) How do the mechanisms of endothelium-dependent dilation change during aging and with the onset of coronary artery disease?
b) What is the role of cellular enzymatic sources of reactive oxygen species in this process?
c) How does the transient receptor potential vanilloid 4 (TRPV4) channel superfamily contributes to vasorelaxation?