Elizabeth Rogers Jacobs, MD
Professor and Associate Dean of Research, MCW,
Associate Chief of Staff, Research and Development, Zablocki, VA
Phone: (414) 384-2000 x41430
Research and Professional Experience
1977-1980 Internship and Residency, University of Kansas School of Medicine, Internal Medicine
1980-1982 Fellowship, Univ. of Arkansas Health Science Center, Pulmonary and Critical Care Medicine
1982-1984 Assistant Professor, University of Oklahoma Health Science Center, Medicine
1984-1987 Assistant Professor and Director of Research, Rush-Presbyterian-St. Luke’s Medical Center
1984-1989 Electrophysiologic Research and Training, Rush-Presbyterian-St. Luke’s Medical Center
1987-1989 Co-Director, Patch Clamp Center, Rush-Presbyterian-St. Luke’s Medical Center
1989 1999 Associate Professor of Medicine and Physiology, Medical College of Wisconsin
1999-present Professor of Medicine and Physiology
2000-present Associate Director, Cardiovascular Research Center, Medical College Wisconsin
2001-present Division Director, Pulmonary and Critical Care Medicine
2004-present Co-director Translational Research Center, Medical College of Wisconsin
Selected Awards And Other Professional Activities
Grant review committee for Chicago Heart Association (1985-1989)
Co-Chairman, Program Committee for Chicago Lung Association sponsored Markfield Conference, October, 1989; Chair 1998-present
Medical Student Honors Thesis Committee MCW member, 1994 to present
Chair, Faculty Development Committee, Department of Medicine, MCW, 1998-2002.
Member Rank and Tenure Committee Medical College of Wisconsin, 2002-present.
Ad hoc reviewer, SBIR and SBTIR scientific review group, March 2000, Feb 2001, October, 2003.
Member Research Committee, Northern Affiliate American Heart Association, 2000- present.
Consulting Editor, American Journal Physiology: Heart, 2000-2005
Member Research Committee, Wisconsin Lung Association, 2001-present.
Member Respiratory and Integrative Biology and Translational Research NIH Study section, 2004 to present.
Lipid Modulators of Pulmonary Vascular Tone.
Studies role of cyp450s in mediating VEGF and NO induced changes in pulmonary vascular tone.
Mechanisms of High Flow Induced Vasculopathy.
The aims of this proposal are to examine the cellular and ionic mechanisms which underlie flow induced vasculopathy localized to the left lower lobe of the lung in juvenile pigs.
Molecular and Cellular Mechanisms Regulating Pressure-Dependent Autoregulation of Microvascular Blood Flow.
Selected Recent Publications
Jacobs ER, Daling Zhu, Stephanie Gruenloh, Bernardo Lopez, Meetha Medhora. VEGF-induced relaxation of pulmonary arteries is mediated by endothelial cytochrome P450 hydroxylase. In press, American Journal of Physiology: Lung cellular and Molecular Physiology, 2006, 291:L36-L77.
Yuenmu Chen, Meetha Medhora, John R. Falck, Kirkwood A. Pritchard Jr., Elizabeth R. Jacobs. Mechanisms of activation of eNOS by 20-hydroxyeicosatetraenoic acid and VEGF in bovine pulmonary artery endothelial cells. American Journal of Physiology: Lung Cellular and Molecular Physiology, 2006, 291:L378-L385 .
Anuradha Dhanasekaran, Rula Al-Saghir, Bernardo Lopez, Ying Gao, David D Gutterman, Elizabeth R. Jacobs and Meetha Medhora: Protective Effects of Epoxyeicosatrienoic acids (EETs) on Human Endothelial Cells from the Pulmonary and Coronary Vasculature. American Journal of Physiology: Heart Circ. Physiol., 2006, 291:H517-H531.
Dunn LK, Gruenloh SK, Dunn BE, Reddy DS, Falck JR, Jacobs ER and Medhora M:Chick chorioallantoic membrane as an in vivo model to study vasoreactivity: characterization of development-dependent hyperemia induced by epoxyeicosatrienoic acids (EETs). Anatomical Records A Discov Mol Cell Evol Biol. 285(2):771-80, 2005.
Medhora M, Daniels J, Mundey K, Fisslthaler B, Busse R, Jacobs ER and Harder DR: Epoxygenase-driven angiogenesis in human lung microvascular endothelial cells. American Journal of Physiology - Heart & Circ. Physiol. 2003, 284:H215-H224.
Publications as listed in PubMed