Associate Professor, Cardiovascular Medicine and Pharmacology and Toxicology
The overall emphasis of Dr. David X. Zhang's research is to understand the cellular mechanisms by which the endothelium regulates blood vessel tone in both normal physiological conditions and disease states, such as ischemic heart disease and hypertension.
Natalya Zinkevich, PhD
Research Scientist I
My research interests are related to vascular health and disease. Specifically, I am interested in the role of endothelial cells in mediating vasodilation. Within this broad topic, I address three questions:
How do the mechanisms of endothelium-dependent dilation change during aging and with the onset of coronary artery disease?
What is the role of cellular enzymatic sources of reactive oxygen species in this process?
How does the transient receptor potential vanilloid 4 (TRPV4) channel superfamily contributes to vasorelaxation?
My current research is focused on understanding the transient receptor potential vanilloid 4 channels to angiotensin II-induced impairment of vasodilation in animals and humans. I am also interested in the role of vascular smooth muscle potassium channels in hydrogen peroxide-induced vasodilation in human arterioles, in health and disease.
My current research is focused on determining whether arachidonic acid (AA) serves as a key upstream mediator of flow-mediated dilation (FMD) in human coronary arteriole (HCA) and define the molecular mechanisms by which AA activates the transient receptor potential vallinoid type 4 (TRPV4) channel in coronary endothelial cells.
MCW Cardiovascular Center
Medical College of Wisconsin
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Milwaukee, WI 53226
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