This group, comprised of Drs. Daisy Sahoo, and Kirkwood Pritchard, fosters collaborative work to improve the content of grants. Dr. Sahoo’s laboratory studies high density lipoproteins (HDL, also known as “good cholesterol”) Dr. Pritchard’s laboratory studies the mechanisms by which chronic inflammation and oxidative stress impair vascular function and induce disease.
This group includes Aoy Tomita-Mitchell, PhD, and Michael E. Mitchell, MD, who are interested in identifying genetic risk factors of heart malformations and in understanding how these genetic alterations impact pathways at the molecular level.
The group centers its research efforts on applying tools to measure the health of blood vessels to determine novel inﬂuences on blood vessel health.
Although it is evident that the common forms of hypertension are multifactorial (polygenic and environmental), little significant progress has been made in identifying the specific genetic basis of human hypertension.
The microvascular function affinity group is formed by the laboratories of Drs. David Gutterman, Michael Widlansky, and David Zhang. The research conducted in this affinity group focuses on the regulation of microvascular reactivity in health and disease states.
This group will examine overwhelming infections, called sepsis, that frequently lead to lung failure (called Respiratory Distress Syndrome, or RDS). These conditions consistently lead as causes of admission to Intensive Care Units.
The overall goal of this multi-laboratory investigation is to understand how human pluripotent stem cells, defined as cells that if left to their own designs can develop into any of the more than 200 cell types in the human body, can be channeled to exclusively become heart muscle cells.
The common themes explored by work in the laboratories of members of this group are centered upon the physiological and pathophysiological consequences of renal ischemia/ reperfusion (I/R) injury. Renal I/R injury is a commonly employed model of acute kidney injury (AKI), also known as acute renal failure.
The common theme connecting these investigators is an interest in cutting-edge technologies for answering fundamental questions about mammalian biology and disease. Combined efforts in several labs also have goals of developing stem cell technology for engineering genetic changes in laboratory model organisms, developing tissues that can be manipulated and studied in vitro, and understanding organ development.
Blood vessels are formed by two distinct processes, namely vasculogenesis, which is the process of formation of endothelial tube directly from immature cells, and angiogenesis, which is the formation of endothelial tube via extension of an existing vessel. Vasculogenesis and angiogenesis play critical roles in development and disease.
Stephanie GruenlohResearch Support Specialist(414) 955-4397 | firstname.lastname@example.org
Cardiovascular CenterMedical College of Wisconsin8701 Watertown Plank Rd.Milwaukee, WI 53226-0509
Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53226
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