Andrew Schwab

Andrew_SchwabGraduate Student
Medical College of Wisconsin
Department of Cell Biology, Neurobiology & Anatomy
8701 Watertown Plank Road
Milwaukee, WI 53226

(414) 955-7433
(414) 955-6517 (fax)
ajschwab@mcw.edu

BS, Chemistry, University of Minnesota-Duluth, 2008
BS, Biochemistry/Molecular Biology, University of Minnesota-Duluth, 2008

Faculty Advisor: Allison Ebert, PhD

Research Area: Stem cell modeling of Parkinson's Disease

Parkinson’s disease patients suffer from both motor and non-motor symptoms, and due to the differentiation capacity of iPSCs, I can take advantage of this system to study multiple cell types that may be impacted by disease processes. Specifically, I am investigating the effect of LRRK2 G2019S on dopamine, sensory and glutamatergic neuron morphology and function. Interestingly, I observe neurite aggregations and mitochondria defects in these neurons with increased severity in dopamine neurons. Determining the cause and consequences of neurite and mitochondrial deficits on dopamine, sensory and glutamatergic neuron function and survival from LRRK2 G2019S iPSCs may provide insight into the underlying mechanisms of motor and non-motor symptoms in PD.

Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53226
(414) 955-8296
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