Karen Giles

Karen_HansenGraduate Student
Medical College of Wisconsin
Department of Cell Biology, Neurobiology & Anatomy
8701 Watertown Plank Road
Milwaukee, WI 53226-3548

(414) 955-5748
(414) 955-6517 (fax)

MS, Mayo Clinic College of Medicine, 2004

Faculty Advisor: Lisa Cirillo, PhD

Research Area: How genes are activated for the first time by pioneer transcription factors during human liver development

I am particularly interested in how the pioneer transcription factor,FoxO1, impacts human liver development. FoxO1 is required for regulating the expression of vital metabolic genes expressed in the liver. Our lab has found that not only does FoxO1 activate these genes, but is able to open chromatin and allow for the initial expression of these genes. I am studying how FoxO1 opens compacted chromatin at these target genes and when this occurs during human hepatocyte differentiation. Additionally, I am interested in how FoxO1 impacts pluripotency in human induced pluripotent stem cells and whether chromatin remodeling plays a role.



Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53226
(414) 955-8296
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