Medical College of Wisconsin
Department of Cell Biology, Neurobiology & Anatomy
8701 Watertown Plank Road
Milwaukee, WI 53226-3548
(414) 955-6517 (fax)
BS, Biochemistry, University of Wisconsin-Madison, 2010
Faculty Advisor: Ramani Ramchandran, PhD
Research Area: T-cell Differentiation, Drug Discovery
In response to viral infection, naive T-cells differentiate into short-lived effector cells (SLEC) and memory progenitor cells (MPC). While this differentiation is well characterized, the exact mechanism governing this process is not fully understood. Our research focuses on the role of phosphatases in regulating T-cell differentiation in response to infection. Concurrently, we are developing novel pharmaceutical compounds to modulate that differentiation.
Identification of inhibitors that target dual-specificity phosphatase 5 provide new insights into the binding requirements for the two phosphate pockets.
Neumann TS, Span EA, Kalous KS, Bongard R, Gastonguay A, Lepley MA, Kutty RG, Nayak J, Bohl C, Lange RG, Sarker MI, Talipov MR, Rathore R, Ramchandran R, Sem DS. BMC Biochem. 2015 Aug 19;16(1):19. doi: 10.1186/s12858-015-0048-3.
Protein expression, characterization and activity comparisons of wild type and mutant DUSP5 proteins.
Nayak J, Gastonguay AJ, Talipov MR, Vakeel P, Span EA, Kalous KS, Kutty RG, Jensen DR, Pokkuluri PR, Sem DS, Rathore R, Ramchandran R. BMC Biochem. 2014 Dec 18;15:27. doi: 10.1186/s12858-014-0027-0.
The cancer stem cell paradigm: a new understanding of tumor development and treatment.
Ebben JD, Treisman DM, Zorniak M, Kutty RG, Clark PA, Kuo JS. Expert Opin Ther Targets. 2010 Jun;14(6):621-32. doi: 10.1517/14712598.2010.485186. Review.