Free Radical Research Center

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Jacek Zielonka, PhD
(414) 955-4789
jzielonk@mcw.edu

 

 

List of Free Radical Research Center publications from the past five years

 

2014

 

Cheng, G., Zielonka, J., McAllister, D., Tsai, S., Dwinell, M.B., Kalyanaraman, B.  Profiling and targeting of cellular bioenergetics: Inhibition of pancreatic cancer cell proliferation.  Br. J. Cancer 111:85-93, 2014. 

Dranka BP, Gifford A, McAllister D, Zielonka J, Joseph J, O’Hara CL, Stucky CL, Kanthasamy AG, Kalyanaraman, B.  A novel mitochondrially-targeted apocynin derivative prevents hyposmia and loss of motor function in the leucine-rich repeat kinase 2 (LRRK2R1441G) transgenic mouse model of Parkinson’s disease.  Neurosci. Lett.  583:159-64, 2014. 

Hardy M, Poulhès F, Rizzato E, Rockenbauer A, Banaszak K, Karoui H, Lopez M, Zielonka J, Vasquez-Vivar J, Sethumadhavan S, Kalyanaraman, B, Tordo P, Ouari O.  Mitochondrial targeted spin traps: synthesis, superoxide spin trapping and mitochondrial uptake.  Chem. Res. Toxicol. 2014 Jun 2. [Epub ahead of print] 

Koto, T., Michalski, R., Zielonka, J., Joseph, J., Kalyanaraman, B.  Detection and identification of oxidants formed during •NO/O2•– reaction: A multi-well plate CW-EPR spectroscopy combined with HPLC analyses.  Free Radic. Res. 48:478-86, 2014.

Kumar A, Chen SH, Kadiiska MB, Hong JS, Zielonka J, Kalyanaraman, B, Mason RP.  Inducible nitric oxide synthase is key to peroxynitrite-mediated, LPS-induced protein radical formation in murine microglial BV2 cells.  Free Radic. Biol. Med. 73:51-9, 2014.

Michalski, R., Michalowski, B., Sikora, A., Zielonka, J., Kalyanaraman, B.  On the use of fluorescence lifetime imaging and dihydroethidium to detect superoxide in intact animals and ex vivo tissues: A reassessment.  Free Radic. Biol. Med. 67:278-284, 2014. PMID: 24200598

Michalski R, Zielonka J, Gapys E, Marcinek A, Joseph J, Kalyanaraman, B.  Real time measurements of amino acid and protein hydroperoxides using coumarin boronic acid. J. Biol. Chem. 289:22536-53, 2014.  [PMCID: PMC4139259; Available on 2015/8/8]

Mouradian M, Kikawa KD, Dranka BP, Komas SM, Kalyanaraman, B, Pardini RS.  Docosahexaenoic acid attenuates breast cancer cell metabolism and the Warburg phenotype by targeting bioenergetic function.  Molec. Carcinogen.  2014 Apr 12. doi: 10.1002/mc.22151. [Epub ahead of print]

Pan J, Zhang Q, Liu Q, Komas SM, Kalyanaraman B, Lubet RA, Wang Y, You M.  Honokiol Inhibits Lung Tumorigenesis through Inhibition of Mitochondrial Function.  Cancer Prev. Res. (Phila.)  2014 Sep 22. pii: canprevres.0091.2014. [Epub ahead of print] 

Shah G, Zielonka J, Chen F, Zhang G, Cao Y, Kalyanaraman B, See W.  H2O2 Generation by bacillus Calmette-Guérin Induces the Cellular Oxidative Stress Response Required for bacillus Calmette-Guérin Direct Effects on Urothelial Carcinoma Biology.  J. Urol. 2014 Jun 10. pii: S0022-5347(14)03738-0. doi: 10.1016/j.juro.2014.05.115. [Epub ahead of print]  PMID: 24928267

Zielonka, J., Cheng, G., Zielonka, M., Ganesh, T., Sun, A., Joseph, J., Michalski, R., O’Brien, W.J., Lambeth, J.D., Kalyanaraman, B.  High-throughput assays for superoxide and hydrogen peroxide: Design of a screening workflow to identify inhibitors of NADPH oxidases.  J. Biol. Chem. 289:16176-89, 2014. 

 

2013

 

Cheng, G., Zielonka, J., McAllister, D.M., Mackinnon, A.C. Jr, Joseph, J., Dwinell, M.B., Kalyanaraman, B.  Mitochondria-targeted vitamin E analogs inhibit breast cancer cell energy metabolism and promotes cell death.  BMC Cancer 2013 Jun 13;13(1):285.  doi: 10.1186/1471-2407-13-285. 

Cunniff, B., Benson, K., Stumpff, J., Newick, K., Held, P., Taatjes, D., Joseph, J., Kalyanaraman, B., Heintz, N.H.  Mitochondrial-targeted nitroxides disrupt mitochondrial architecture and inhibit expression of peroxiredoxin 3 and FOXM1 in malignant mesothelioma cells.  J. Cell. Physiol. 228:835-45, 2013

Dickey, J.S., Gonzalez, Y., Aryal, B., Mog, S., Nakamura, A.J., Redon, C.E., Baxa, U., Rosen, E., Cheng, G., Zielonka, J., Parekh, P., Mason, K.P., Joseph, J., Kalyanaraman, B., Bonner, W., Herman, E., Shacter, E., Rao, V.A.  Mito-Tempol and dexrazoxane exhibit cardioprotective and chemotherapeutic effects through specific protein oxidation and autophagy in a syngeneic breast tumor preclinical model.  PLoS ONE 2013 Aug 5;8(8):e70575. doi: 10.1371/journal.pone.0070575. Print 2013. 

Dilip, A., Cheng, G., Joseph, J., Kunnimalaiyaan, S., Kalyanaraman, B., Kunnimalaiyaan, M., Gamblin, T.C.  Mitochondria-targeted antioxidant and glycolysis inhibition – Synergistic therapy in hepatocellular carcinoma.  Anti-Cancer Drugs 24:881-8, 2013. 

Dranka, B.P., Gifford, A., Ghosh, A., Zielonka, J., Joseph, J., Kanthasamy, A.G., Kalyanaraman, B.  Diapocynin prevents early Parkinson's disease symptoms in the Leucine-Rich Repeat Kinase 2 (LRRK2R1441G) transgenic mouse.  Neurosci. Lett. 549:57-62, 2013

Huang, C.H., Shan, G.Q., Mao, L., Kalyanaraman, B.,Qin, H., Ren, F.R., Zhu, B.Z.  The first purification and unequivocal characterization of the radical form of the carbon-centered quinone ketoxy radical adduct.  Chem Commun (Camb). 49:6436-8, 2013. 

Jin H, Kanthasamy A, Ghosh A, Anantharam V, Kalyanaraman, B., Kanthasamy AG.  Mitochondria-targeted antioxidants for treatment of Parkinson's disease: Preclinical and clinical outcomes.  Biochim. Biophys. Acta 2013 Sep 20. doi:pii: S0925-4439(13)00286-X. 10.1016/j.bbadis.2013.09.007. [Epub ahead of print] 

Kalyanaraman, B.  Teaching the basics of redox biology to medical and graduate students: Oxidants, antioxidants and disease mechanisms.  Redox Biol. 1:244-257, 2013. 

Kalyanaraman, B., Dranka, B.P., Hardy, M., Michalski, R., Zielonka, J.  HPLC-based monitoring of products formed from hydroethidine-based fluorogenic probes – The ultimate approach for intra-and extracellular superoxide detection.  Biochim. Biophys. Acta 2013 May 10. doi:pii: S0304-4165(13)00204-3. 10.1016/j.bbagen.2013.05.008. [Epub ahead of print]. 

Michalski, R., Zielonka, J., Hardy, M., Joseph, J., Kalyanaraman, B.  Hydropropidine:  A novel, cell-impermeant fluorogenic probe for detecting extracellular superoxide.  Free Radic. Biol. Med. 54:135-47, 2013. 

Myers, J.M., Cheng, Q., Antholine, W., Kalyanaraman, B., Filipofska, A., Arner, E., Myers, C.R.  Redox activation of Fe(III)-thiosemicarbazones and Fe(III)-bleomycin by thioredoxin reductase: specificity of enzymatic redox centers and analysis of reactive species formation by ESR spin trapping.  Free Radic. Biol. Med. 60:183-194, 2013. 

Ntantie, E., Gonyo, P., Lorimer, E.L., Hauser, A.D., Schuld, N., McAllister, D., Kalyanaraman, B., Dwinell, M.B., Auchampach, J.A., Williams, C.L.  An Adenosine-mediated signaling pathway suppresses prenylation of the GTPase Rap1B and promotes cell scattering.  Sci. Signal. 2013 May 28;6(277):ra39. doi: 10.1126/scisignal.2003374. 

Qin, H., Huang, C.H., Mao, L., Xia, H.Y., Kalyanaraman, B., Shao, J., Shan, G.Q., Zhu, B.Z.  Molecular mechanism of metal-independent decomposition of lipid hydroperoxide 13-HPODE by halogenated quinoid carcinogens.  Free Radic. Biol. Med. 63:459-66, 2013. 

Shah, G., Zhang, G., Chen, F., Cao, Y., Kalyanaraman, B., See, W.  Loss of BCG Viability adversely affects the direct response of urothelial carcinoma cells to BCG exposure.   J. Urol. 2013 Sep 10. doi:pii: S0022-5347(13)05381-0. 10.1016/j.juro.2013.09.012. [Epub ahead of print] 

Shah, G., Zhang, G., Chen, F., Cao, Y., Kalyanaraman, B., See, W.A.  iNOS expression and NO production contribute to the direct effects of BCG on urothelial carcinoma cell biology.  Urol. Oncol. 2013 Sep 17. pii: S1078-1439(13)00254-8. doi: 10.1016/j.urolonc.2013.06.005. [Epub ahead of print]  

Shao, J., Huang, C.H., Kalyanaraman, B., Zhu, B.Z.  Potent methyl oxidation of 5-methyl-2'-deoxycytidine by halogenated quinoid carcinogens and hydrogen peroxide via a metal-independent mechanism.  Free Radic. Biol. Med. 60:177-82, 2013. 

Sikora, A., Zielonka, J., Adamus, J., Debski, D., Dybala-Defratyka, A., Michalowski, B., Joseph, J., Hartley, R.C., Murphy, M.P., Kalyanaraman, B.  Reaction between peroxynitrite and triphenylphosphonium-substituted arylboronic acid isomers: identification of diagnostic marker products and biological implications.  Chem. Res. Toxicol. 26:856-67, 2013. 

Srinivasan, S., Spear, J., Chandran, K., Joseph, J., Kalyanaraman, B., Avadhani, N.G.  Oxidative stress induced mitochondrial protein kinase a mediates cytochrome C oxidase dysfunction.  PLoS One 2013 Oct 10;8(10):e77129. doi: 10.1371/journal.pone.0077129. 

Valez, V., Cassina, A., Batinic-Haberle, I., Kalyanaraman, B., Ferrer-Sueta, G., Radi, R.  Peroxynitrite formation in nitric oxide-exposed submitochondrial particles: Detection, oxidative damage and catalytic removal by Mn-porphyrins.  Arch. Biochem. Biophys. 529:45-54, 2013. 

Zielonka, J., Lambeth, J.D., Kalyanaraman, B.  On the use of L-012, a luminol-based chemiluminescent probe, for detecting superoxide and identifying inhibitors of NADPH oxidase: A re-evaluation.  Free Radic. Biol. Med. 2013 Sep 27;65C:1310-1314. doi: 10.1016/j.freeradbiomed.2013.09.017. [Epub ahead of print]. 

 

2012

 

Bansal, S., Srinivasan, S., Anandasadagopan, S., Chowdhury, A.R., Selvaraj, .V, Kalyanaraman, B., Joseph, J., Avadhani, N.G.  Additive effects of mitochondria-targeted Cytochrome P4502E1 and alcohol toxicity on cytochrome c oxidase function and the stability of respirosome complexes.  J. Biol. Chem. 287:15284-97, 2012. [PMCID: PMC3346148]

Cheng, G., Zielonka, J., Dranka, B.P., McAllister, D., Mackinnon, A.C. Jr., Joseph, J., Kalyanaraman, B.  Mitochondria targeted drugs synergize with 2-deoxyglucose to trigger breast cancer cell death.  Cancer Res. 72:2634-44, 2012.  [PMCID: PMC3700358]

Dranka, B.P., Zielonka, J., Kanthansamy, A.G., Kalyanaraman, B.  Alterations in bioenergetics function induced by Parkinson’s disease mimetic compounds:  Lack of correlation with superoxide generation.  J. Neurochem. 122:941-51, 2012.   [PMCID: PMC3423581]

Ghosh, A., Kanthasamy, A., Joseph, J., Anantharam, V., Srivastava, P., Dranka, B.P., Kalyanaraman, B., Kanthasamy, A.G.  Anti-inflammatory and neuroprotective effects of an orally active apocynin derivative in pre-clinical models of Parkinson's disease.  J. Neuroinflammation 9(1):241-, 2012. 

Kalyanaraman, B., Darley-Usmar, V., Davies, K.J., Dennery, P.A., Forman, H.J., Grisham, M.B., Mann, G.E., Moore, K., Roberts, L.J. II, Ischiropoulos, H.  Measuring reactive oxygen and nitrogen species with fluorescent probes:  challenges and limitations.  Free Radic. Biol. Med. 52:1-6, 2012.  [PMCID: PMC3911769]

Mukhopadhyay, P., Horváth, B., Zsengellėr, Z., Bátkai, S., Cao, Z., Kechrid, M., Holovac, E., Erdėlyi, K., Tanchian, G., Liaudet, L., Stillman, I.E., Joseph, J., Kalyanaraman, B., Pacher, P.  Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia-reperfusion: therapeutic potential of mitochondrially-targeted antioxidants.  Free Radic. Biol. Med. 53:1123-38, 2012.  [PMCID: PMC3432152]

Mukhopadhyay, P., Horvath, B., Zsengeller, Z., Zielonka, J., Tanchian, G., Holovac, E., Kechrid, M., Patel, V., Stillman, I.E., Parikh, S.M., Joseph, J., Kalyanaraman, B., Pacher, P.  Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy.  Free Radic. Biol. Med. 52:497-506, 2012.  [PMCID: PMC3253235]

Petruk, A.A., Bartesaghi, S., Trujillo, M., Estrin, D.A., Murgida, D., Kalyanaraman, B., Marti, M.A., Radi, R.  Molecular basis of intramolecular electron transfer in proteins during radical-mediated oxidations: Computer simulation studies in model tyrosine-cysteine peptides in solution.  Arch. Biochem. Biophys. 525:82-91, 2012.  [PMCID: PMC3414218]

Soberanes, S., Gonzalez, A., Urich, D., Chiarella, S.E., Radigan, K.A., Osornio-Vargas, A., Joseph, J., Kalyanaraman, B., Ridge, K.M., Chandel, N.S., Mutlu, G.M., De Vizcaya-Ruiz, A., Budinger, G.R.S.  Particulate matter air pollution induces hypermethylation of the p16 promoter via a mitochondrial ROS-JNK-DNMT1 pathway.  Sci. Rep. 2:275, 2012.  [PMCID: PMC3281276]

Trumbull, K.A., McAllister, D., Gandelman, M.M., Fung, W.Y., Lew, T., Brennan, L., Lopez, N. Morré J., Kalyanaraman, B., Beckman, J.S.  Diapocynin and apocynin administration fails to significantly extend survival in G93A SOD1 ALS mice.  Neurobiol. Dis. 45:137-44, 2012

Zhu, B.Z., Mao, L., Huang, C.H., Qin, H., Fan, R.M., Kalyanaraman, B., Zhu, J.G.  Unprecedented hydroxyl radical-dependent two-step chemiluminescence production by polyhalogenated quinoid carcinogens and H2O2.  Proc. Natl. Acad. Sci. USA 109:16046-51, 2012.  [PMCID: PMC3479549]

Zielonka, J., Sikora, A., Hardy, M., Joseph, J., Dranka, B.P., Kalyanaraman, B.  Boronate probes as diagnostic tools for real time monitoring of peroxynitrite and hydroperoxides.  Chem. Res. Toxicol. 25:1793-9, 2012.  [PMCID: PMC3501381]

Zsengellér, Z.K., Ellezian, L., Brown, D., Horváth, B., Mukhopadhyay, P., Kalyanaraman, B., Parikh, S.M., Karumanchi, S.A., Stillman, I.E., Pacher, P.  Cisplatin nephrotoxicity involves mitochondrial injury with impaired tubular mitochondrial enzyme activity.  J.  Histochem. Cytochem. 60:521-9, 2012. [PMCID: PMC3460350]

 

2011

 

Chacko, B.K., Srivastava, A., Johnson, M., Benavides, G.A., Chang, M.J., Ye, Y., Jhala, N., Murphy, M.P., Kalyanaraman, B., Usmar, V.D.  The mitochondria-targeted ubiquinone MitoQ decreases ethanol-dependent micro and macro hepatosteoatosis.  Hepatology 54:153-63, 2011. 

Cheng, G., Lopez, M., Zielonka, J., Hauser, A.D., Joseph, J., McAllister, D., Rowe, J.J., Sugg, S.L., Williams, C.L., Kalyanaraman, B.  Mitochondria-targeted nitroxides exacerbate Fluvastatin-mediated cytostatic and cytotoxic effects in breast cancer cells.  Cancer Biol. Ther.  12:707-17, 2011. 

Kalyanaraman, B.  Oxidative chemistry of fluorescent dyes:  Implications in the detection of reactive oxygen and nitrogen species.  Biochem. Soc. Trans. 39:1221-5, 2011. 

Khan, S.A., Nanduri, J., Yuan, G., Kinsman, B., Kumar, G.K., Joseph, J., Kalyanaraman, B., Prabhakar, N.R. NADPH oxidase2 mediates intermittent hypoxia-induced mitochondrial complex I inhibition:  Relevance to blood pressure changes in rats.  Antioxid. Redox Signal. 14:533-42, 2011.  [PMCID: PMC3038125]

Kumar, S.N., Konorev, E.A., Aggarwal, D., Kalyanaraman, B.  Analysis of proteome changes in doxorubicin-treated adult rat cardiomyocyte.  J. Proteomics 74:683-97, 2011. 

Murphy, M.P., Holmgren, A., Larsson, N.G., Halliwell, B., Chang, C.J., Kalyanaraman, B., Rhee, S.G., Thornally, P.J., Partridge, L, Gems, D., Nyström, T., Belousov, V., Schumacker, P.T., Winterbourn, C.C.  Unraveling the biological roles of reactive oxygen species.  Cell Metab. 13:361-6, 2011. 

Sikora, A., Zielonka, J., Lopez, M., Dybala-Defratyka, A., Joseph, J., Marcinek, A., Kalyanaraman, B.  Reaction between peroxynitrite and boronates: EPR spin-trapping, HPLC analyses, and quantum mechanical study of the free radical pathway.  Chem. Res. Toxicol. 24:687-97, 2011.  Featured “In this Issue”. 

Tormos, K.V., Anso, E., Hamanaka, R.B., Eisenhart, J., Joseph, J., Kalyanaraman, B., Chandel, N.S.  Mitochondrial complex III ROS regulate adipocyte differentiation.  Cell Metab. 14:537-44, 2011. 

Zhu, B.Z., Mao, L., Fan, R.M., Zhu, J.G., Zhang, Y.N., Wang, J., Kalyanaraman, B., Frei, B.  Ergothioneine prevents copper-induced oxidative damage to DNA and protein by forming a redox-inactive ergothioneine-copper complex.  Chem. Res. Toxicol. 24:30-4, 2011. 

Zielonka, J., Zielonka, M., Sikora, A., Adamus, J., Hardy, M., Ouari, O., Dranka, B.P., Kalyanaraman, B.  Global profiling of reactive oxygen and nitrogen species in biological systems:  High-throughput real-time analyses.  J. Biol. Chem. 287:2984-95, 2011.  Featured “Paper of the Week”. 

 

2010

 

Bartesaghi, S., Wenzel, J., Trujillo, M., Lopez, M., Joseph, J., Kalyanaraman, B., Radi, R.  Lipid peroxyl radicals mediate tyrosine dimerization and nitration in membranes.  Chem. Res. Toxicol. 23:821-35, 2010.  [PMCID: PMC3506709]

Basu S, Keszler A, Azarova NA, Nwanze N, Perlegas A, Shiva S, Broniowska KA, Hogg N, Kim-Shapiro DB. A Novel Role for Cytochrome c: Efficient Catalysis of S-Nitrosothiol Formation. Free Radic Biol Med. 2010 Jan 15;48(2):255-63.

Chacko, B., Reily, C., Srivastava, A., Johnson, M.S., Ulasova, E., Agarwal, A., Zinn, K., Murphy, M.P., Kalyanaraman, B., Darley-Usmar, V.  Prevention of diabetic nephropathy in Ins2+/-AkitaJ mice by the mitochondria-targeted therapy Mito-Q.  Biochem. J. 432:9-19, 2010.  [PMCID: PMC2973231]

Chahdi A, Sorokin A. Endothelin-1 induces p66Shc activation through EGF receptor transactivation: Role of beta(1)Pix/Galpha(i3) interaction. Cell Signal. 2010 Feb;22(2):325-9.

Chandran, K., McCracken, J, Peterson, F.C., Antholine, W.E., Volkman, B.F., Kalyanaraman, B.  Oxidation of histidine residues in copper-zinc superoxide dismutase by bicarbonate stimulated peroxidase and thiol oxidase activities:  Pulse EPR and NMR studies.  Biochemistry 49:10616-22, 2010.  [PMCID: PMC3501376]

Cheng, Q., Antholine, W.E., Myers, J.M., Kalyanaraman, B., Arner, E.S., Myers, C.R.  The selenium-independent inherent pro-oxidant NADPH oxidase activity of mammalian thioredoxin reductase and its selenium-dependent direct peroxidase activities.  J. Biol. Chem. 285:21708-23, 2010

Dasgupta, J., Kar, S., Liu, R., Joseph, J., Kalyanaraman, B., Remington, S.J., Chen, C., Melendez, J.A.  Reactive oxygen species control senescence-associated matrix metaolloproteinase-1 through c-Jun-N-terminal kinase.  J. Cell. Physiol. 225:52-62, 2010.  [PMCID: PMC2913426]

Diers, A.R., Higdon, A.N., Ricart, K.C., Johnson, M.S., Agarwal, A., Kalyanaraman, B., Landar, A., Darley-Usmar, V.M.  Mitochondrial targeting of the electrophilic lipid 15-deoxy-Delta12,14-Prostaglandin J2 increases apoptotic efficacy via redox cell signaling mechanisms.  Biochem. J. 426:31-41, 2010.  [PMCID: PMC3079364]

Ghosh, A., Chandran, K., Kalivendi, S.V., Joseph, J., Antholine, W.E., Hillard, C.J., Kanthasamy, A., Kanthasamy, A., Kalyanaraman, B. Neuroprotection by mitochondria-targeted drug in Parkinson’s disease model.  Free Radic. Biol. Med. 49:1674-84, 2010.  [PMCID: PMC4020411]

Goetz BI, Shields HW, Basu S, Wang P, King SB, Hogg N, Gladwin MT, Kim-Shapiro DB. An electron paramagnetic resonance study of the affinity of nitrite for methemoglobin. Nitric Oxide 2010 Feb 15;22(2):149-54.

Kalivendi, S.V., Yedlapudi, D., Hillard, C.J., Kalyanaraman, B.  Oxidants induce alternative splicing of alpha-synuclein:  implications for Parkinson’s disease.  Free Radic. Biol. Med. 48:377-83, 2010. 

Keszler A, Zhang Y, Hogg N. Reaction among nitric oxide, glutathione, and oxygen in the presence and absence of protein: How are S-nitrosothiols formed? Free Radic Biol Med. 2010 Jan 1;48(1):55-64.

Migrino RQ, Hari P, Gutterman DD, Bright M, Truran S, Schlundt B, Phillips SA. Systemic and microvascular oxidative stress induced by light chain amyloidosis. Int J Cardiol. 2010 Nov 5;145(1):67-8.

Pieper, G.M., Khanna, A.K.  Oxidative stress in cardiac transplantation.  In: Studies on Cardiovascular Disorders.  Oxidative Stress in Applied Basic Research and Clinical Practice.  Shah, A., Sauer, H. and Laurindo, F., eds.  Humana Press/Springer Services, 2010, pp 349-371

Rao, A., Klein, S.R., Bonar, S.J., Zielonka, J., Mizuno, N., Dickey, J.S., Keller P.W., Joseph, J., Kalyanaraman, B., Shacter, E.  The antioxidant transcription factor Nrf2 negatively regulates autophagy and growth arrest induced by the anticancer redox agent mitoquinine.  J. Biol. Chem. 285:34447-59, 2010.  [PMCID: PMC2966059]

Subramanian S, Kalyanaraman B, Migrino RQ. Mitochondrially Targeted Antioxidants for the Treatment of Cardiovascular Diseases. Recent Pat Cardiovasc Drug Discov. 2010 Jan;5(1):54-65.

Shchepin, R., Möller, M.N., Kim, H.Y., Hatch, D.M., Bartesaghi, S., Kalyanaraman, B., Radi, R., Porter, N.A.  Tryosine-lipid peroxidation adducts from radical termination:  para coupling and intramolecular Diels-Alder cyclization.  J. Am. Chem. Soc. 132:17490-500, 2010.  [PMID: 21090613]

Srinivasan, S., Koenigstein, A., Joseph, J., Sun, L., Kalyanaraman, B., Zaidi, M., Avadhani, N.G.  Role of mitochondrial ROS in osteoclast differentiation.  Ann. N. Y. Acad. Sci. 1192:245-52, 2010.  [PMCID: PMC2856121]

Subramanian, S., Kalyanaraman, B., Migrino, R.Q.  Mitochondrially targeted antioxidants for the treatment of cardiovascular diseases.  Recent Pat. Cardiovasc. Drug Discov. 5:54-65, 2010.  Review. 

Weinberg, F., Hamanaka, R., Wheaton, W.W., Weinberg, S., Joseph, J., Lopez, M., Kalyanaraman, B., Mutlu, G.M., Budinger, G.R., Chandel, N.S.  Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity.  Proc. Natl. Acad. Sci. USA 107:8788-93, 2010.  [PMCID: PMC2889315]

Zhu, B.Z., Zhu, J.G., Mao, L., Kalyanaraman, B., Shan, G.Q.  Detoxifying carcinogenic polyhalogenated quinones by hydroxamic acids via an unusual double Lossen rearrangement mechanism.  Proc. Natl. Acad. Sci. U.S.A. 107:20686-90, 2010.  [PMCID: PMC2996439]

Zielonka, J., Hardy, M., Kalyanaraman, B.  Corrigendum to “HPLC study of oxidation products of hydroethidine in chemical and biological systems:  Ramifications in superoxide measurements”.  Free Radic. Biol. Med. 48:373, 2010. 

Zielonka, J., Kalyanaraman, B.  Hydroethidine- and Mito-SOX-derived red fluorescence is not a reliable indicator of intracellular superoxide formation:  Another inconvenient truth.  Free Radic. Biol. Med. 48:983-1001, 2010.  Review.  [PMC3587154]

Zielonka, J., Sikora, A., Joseph, J., Kalyanaraman, B.  Peroxynitrite is the major species formed from different flux ratios of co-generated nitric oxide and superoxide:  Direct reaction with boronate-based fluorescent probe.  J. Biol. Chem. 285:14210-6, 2010.  Featured “Paper of the Week.”  [PMCID: PMC2863194]

 

2009

 

Alexanian A, Rufanova VA, Miller B, Flasch A, Roman RJ, Sorokin A. Down-regulation of 20-HETE synthesis and signaling inhibits renal adenocarcinoma cell proliferation and tumor growth. Anticancer Res. 2009 Oct;29(10):3819-24.

Ali I, Rafiee P, Zheng Y, Johnson C, Banerjee B, Haasler G, Jacob H, Shaker R. Intramucosal distribution of WNT signaling components in human esophagus. J Clin Gastroenterol. 2009 Apr;43(4):327-37.

Amour J, Brzezinska AK, Weihrauch D, Billstrom AR, Zielonka J, Krolikowski JG, Bienengraeber MW, Warltier DC, Pratt PF Jr, Kersten JR. Role of heat shock protein 90 and endothelial nitric oxide synthase during early anesthetic and ischemic preconditioning. Anesthesiology. 110(2):317-25, 2009. Erratum in: Anesthesiology. 110(6):1435, 2009.

An J, Du J, Wei N, Xu H, Pritchard KA Jr, Shi Y. Role of tetrahydrobiopterin in resistance to myocardial ischemia in Brown Norway and Dahl S rats. Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1783-91.

Bhowmick R, Girotti AW. Signaling events in apoptotic photokilling of 5-aminolevulinic acid-treated tumor cells: inhibitory effects of nitric oxide. Free Radic Biol Med. 2009 Sep 15;47(6):731-40.

Bodiga S, Zhang R, Jacobs DE, Larsen BT, Tampo A, Manthati VL, Kwok WM, Zeldin DC, Falck JR, Gutterman DD, Jacobs ER, Medhora MM. Protective actions of epoxyeicosatrienoic acid: dual targeting of cardiovascular PI3K and KATP channels. J Mol Cell Cardiol. 2009 Jun;46(6):978-88.

Bongard RD, Lindemer BJ, Krenz GS, Merker MP. Preferential utilization of NADPH as the endogenous electron donor for NAD(P)H:quinone oxidoreductase 1 (NQO1) in intact pulmonary arterial endothelial cells. Free Radic Biol Med. 2009 Jan 1;46(1):25-32.

Cao S, Wang LC, Kwansa H, Roman RJ, Harder DR, Koehler RC Endothelin rather than 20-HETE contributes to loss of pial arteriolar dilation during focal cerebral ischemia with and without polymeric hemoglobin transfusion. Am J Physiol Regul Integr Comp Physiol. 2009 May;296(5):R1412-8.

Chandran K, Aggarwal D, Migrino RQ, Joseph J, McAllister D, Konorev EA, Antholine WE, Zielonka J, Srinivasan S, Avadhani NG, Kalyanaraman B. Doxorubicin inactivates myocardial cytochrome c oxidase in rats: cardioprotection by Mito-Q. Biophys J. 96(4):1388-98, 2009.

Dhanasekaran A, Bodiga S, Gruenloh S, Gao Y, Dunn L, Falck JR, Buonaccorsi JN, Medhora M, Jacobs ER. 20-HETE increases survival and decreases apoptosis in pulmonary arteries and pulmonary artery endothelial cells. Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H777-86.

Du J, Wei N, Guan T, Xu H, An J, Pritchard KA Jr, Shi Y. Inhibition of CDKS by roscovitine suppressed LPS-induced *NO production through inhibiting NF-kappaB activation and BH4 biosynthesis in macrophages. Am J Physiol Cell Physiol. 2009 Sep;297(3):C742-9.

Du J, Wei N, Xu H, Ge Y, Vásquez-Vivar J, Guan T, Oldham KT, Pritchard KA Jr, Shi Y. Identification and Functional Characterization of Phosphorylation Sites on GTP Cyclohydrolase I. Arterioscler Thromb Vasc Biol. 2009 Dec;29(12):2161-8.

Du J, Xu H, Wei N, Wakim B, Halligan B, Pritchard KA Jr, Shi Y. Identification of proteins interacting with GTP cyclohydrolase I. Biochem Biophys Res Commun. 2009 Jul 24;385(2):143-7.

Galati D, Srinivasan S, Raza H, Prabu SK, Hardy M, Chandran K, Lopez M, Kalyanaraman B, Avadhani NG. Role of nuclear-encoded subunit Vb in the assembly and stability of cytochrome c oxidase complex: implications in mitochondrial dysfunction and ROS production. Biochem J. 420(3):439-49, 2009.

Ghosh SN, Wu Q, Mäder M, Fish BL, Moulder JE, Jacobs ER, Medhora M, Molthen RC. Vascular injury after whole thoracic x-ray irradiation in the rat. Int J Radiat Oncol Biol Phys. 2009 May 1;74(1):192-9.

Gutterman DD. Silent myocardial ischemia. Circ J. 2009 May;73(5):785-97.

Hein TW, Singh U, Vasquez-Vivar J, Devaraj S, Kuo L, Jialal I. Human C-reactive protein induces endothelial dysfunction and uncoupling of eNOS in vivo. Atherosclerosis. 206(1):61-8, 2009.

Hudetz JA, Iqbal Z, Gandhi SD, Patterson KM, Byrne AJ, Hudetz AG, Pagel PS, Warltier DC. Ketamine attenuates post-operative cognitive dysfunction after cardiac surgery. Acta Anaesthesiol Scand. 53(7):864-72, 2009.

Hudetz JA, Patterson KM, Iqbal Z, Gandhi SD, Byrne AJ, Hudetz AG, Warltier DC, Pagel PS. Ketamine attenuates delirium after cardiac surgery with cardiopulmonary bypass. J Cardiothorac Vasc Anesth.23(5):651-7, 2009.

Ji H, Tan S, Igarashi J, Li H, Derrick M, Martásek P, Roman LJ, Vásquez-Vivar J, Poulos TL, Silverman RB. Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy. Ann Neurol. 65(2):209-17, 2009.

Koehler RC, Roman RJ, Harder DR. Astrocytes and the regulation of cerebral blood flow. Trends Neurosci. 2009 Mar;32(3):160-9. Review.

Larsen BT, Bubolz AH, Mendoza SA, Pritchard KA Jr, Gutterman DD. Bradykinin-induced dilation of human coronary arterioles requires NADPH oxidase-derived reactive oxygen species. Arterioscler Thromb Vasc Biol. 2009 May;29(5):739-45.

Larson M, Larson M, Li Z, Larson M, Li Z, Hall CL, Jensen E, McAllister DM, Kalyanaraman B, Zhao M. Physiological fluctuation of (99m)Tc-sestamibi uptake in normal mammary glands: a systematic investigation in female rats. Acta Radiol. 50(9):975-8, 2009.

Li Z, Lopez M, Hardy M, McAllister DM, Kalyanaraman B, Zhao M. A (99m)Tc-labeled triphenylphosphonium derivative for the early detection of breast tumors. Cancer Biother Radiopharm. 24(5):579-87, 2009.

Lohr NL, Keszler A, Pratt P, Bienengraeber M, Warltier DC, Hogg N. Enhancement of nitric oxide release from nitrosyl hemoglobin and nitrosyl myoglobin by red/near infrared radiation: potential role in cardioprotection. J Mol Cell Cardiol. 47(2):256-63, 2009.

Myers JM, Myers CR. The effects of hexavalent chromium on thioredoxin reductase and peroxiredoxins in human bronchial epithelial cells. Free Radic Biol Med 47:1477-85, 2009.

Myers CR, Myers JM. The effects of acrolein on peroxiredoxins, thioredoxins, and thioredoxin reductase in human bronchial epithelial cells. Toxicology. 2009 Mar 4;257(1-2):95-104.

Newman DK. PI3Kbeta goes to the head of its class. Blood. 2009 Sep 3;114(10):2011-2.

Pagel PS, Krolikowski JG, Amour J, Warltier DC, Weihrauch D. Morphine reduces the threshold of helium preconditioning against myocardial infarction: the role of opioid receptors in rabbits. J Cardiothorac Vasc Anesth. 23(5):619-24, 2009.

Pan B, Wang W, Long JZ, Sun D, Hillard CJ, Cravatt BF, Liu QS. Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling. J Pharmacol Exp Ther. 2009 Nov;331(2):591-7.

Pieper GM, Ionova IA, Cooley BC, Migrino RQ, Khanna AK, Whitsett J, Vásquez-Vivar J. Sepiapterin decreases acute rejection and apoptosis in cardiac transplants independently of changes in nitric oxide and inducible nitric-oxide synthase dimerization. J Pharmacol Exp Ther. 2009 Jun;329(3):890-9.

Piknova B, Keszler A, Hogg N, Schechter AN. The reaction of cell-free oxyhemoglobin with nitrite under physiologically relevant conditions: Implications for nitrite-based therapies. Nitric Oxide 20(2):88-94, 2009.

Rabbani ZN, Spasojevic I, Zhang X, Moeller BJ, Haberle S, Vasquez-Vivar J, Dewhirst MW, Vujaskovic Z, Batinic-Haberle I. Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumor. Free Radic Biol Med. 2009 Oct 1;47(7):992-1004.

Rafiee P, Nelson VM, Manley S, Wellner M, Floer M, Binion DG, Shaker R. Effect of curcumin on acidic pH-induced expression of IL-6 and IL-8 in human esophageal epithelial cells (HET-1A): role of PKC, MAPKs, and NF-kappaB. Am J Physiol Gastrointest Liver Physiol. 2009 Feb;296(2):269-98.

Renic M, Klaus JA, Omura T, Kawashima N, Onishi M, Miyata N, Koehler RC, Harder DR, Roman RJ. Effect of 20-HETE inhibition on infarct volume and cerebral blood flow after transient middle cerebral artery occlusion. J Cereb Blood Flow Metab. 2009 Mar;29(3):629-39.

Riego JA, Broniowska KA, Kettenhofen NJ, Hogg N. Activation and inhibition of soluble guanylyl cyclase by S-nitrosocysteine: involvement of amino acid transport system L. Free Radic Biol Med. 47(3):269-74, 2009.

Rufanova VA, Alexanian A, Wakatsuki T, Lerner A, Sorokin A. Pyk2 mediates endothelin-1 signaling via p130Cas/BCAR3 cascade and regulates human glomerular mesangial cell adhesion and spreading. J Cell Physiol. 2009 Apr;219(1):45-56.

Sampath V, Radish AC, Eis AL, Broniowska K, Hogg N, Konduri GG. Attenuation of lipopolysaccharide-induced oxidative stress and apoptosis in fetal pulmonary artery endothelial cells by hypoxia. Free Radic Biol Med. 46(5):663-71, 2009.

Sharma M, McCarthy ET, Reddy DS, Patel PK, Savin VJ, Medhora M, Falck JR. 8,9-Epoxyeicosatrienoic acid protects the glomerular filtration barrier. Prostaglandins Other Lipid Mediat. 2009 Jun;89(1-2):43-51.

Sikora A, Zielonka J, Lopez M, Joseph J, Kalyanaraman B. Direct oxidation of boronates by peroxynitrite: mechanism and implications in fluorescence imaging of peroxynitrite. Free Radic Biol Med. 47(10):1401-7, 2009.

van Faassen EE, Bahrami S, Feelisch M, Hogg N, Kelm M, Kim-Shapiro DB, Kozlov AV, Li H, Lundberg JO, Mason R, Nohl H, Rassaf T, Samouilov A Nitrite as regulator of hypoxic signaling in mammalian physiology. Med Res Rev. 29(5):683-741, 2009. Review.

Van Orman JR, Weihrauch D, Warltier DC, Lough J. Myocardial interstitial fluid inhibits proliferation and cardiomyocyte differentiation in pluripotent embryonic stem cells. Am J Physiol Heart Circ Physiol. 297(4):H1369-76., 2009.

Vásquez-Vivar J. Tetrahydrobiopterin, superoxide, and vascular dysfunction. Free Radic Biol Med. 2009 Oct 15;47(8):1108-19.

Vásquez-Vivar J, Whitsett J, Derrick M, Ji X, Yu L, Tan S. Tetrahydrobiopterin in the prevention of hypertonia in hypoxic fetal brain. Ann Neurol. 2009 Sep;66(3):323-31.

Zhang DX, Mendoza SA, Bubolz AH, Mizuno A, Ge ZD, Li R, Warltier DC, Suzuki M, Gutterman DD. Transient receptor potential vanilloid type 4-deficient mice exhibit impaired endothelium-dependent relaxation induced by acetylcholine in vitro and in vivo. Hypertension. 53(3):532-8, 2009.

Zhang H, Andrekopoulos C, Xu Y, Joseph J, Hogg N, Feix J, Kalyanaraman B. Decreased S-nitrosation of peptide thiols in the membrane interior. Free Radic Biol Med. 47(7):962-8, 2009.

Zhang H, Zielonka J, Sikora A, Joseph J, Xu Y, Kalyanaraman B. The effect of neighboring methionine residue on tyrosine nitration and oxidation in peptides treated with MPO, H2O2, and NO2(-) or peroxynitrite and bicarbonate: role of intramolecular electron transfer mechanism? Arch Biochem Biophys. 484(2):134-45, 2009.

Zhang R, Mio Y, Pratt PF, Lohr N, Warltier DC, Whelan HT, Zhu D, Jacobs ER, Medhora M, Bienengraeber M. Near infrared light protects cardiomyocytes from hypoxia and reoxygenation injury by a nitric oxide dependent mechanism. J Mol Cell Cardiol. 2009 Jan;46(1):4-14.

Zielonka J, Hardy M, Kalyanaraman B. HPLC study of oxidation products of hydroethidine in chemical and biological systems: ramifications in superoxide measurements. Free Radic Biol Med. 46(3):329-38, 2009.

Zhu, B.Z., Shan, G.Q., Huang, C.H., Kalyanaraman, B., Mao, L., Du, Y.G. Metal-independent decomposition of hydroperoxides by halogenated quinones: Detection and identification of a quinone ketoxy radical.  Proc. Natl. Acad. Sci. USA 106:11466-71, 2009.  [PMCID: PMC2710671]

 

 

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