Human and Molecular Genetics Center
The Human and Molecular Genetics Center (HMGC) at the Medical College of Wisconsin was established in 1999 to provide the infrastructure for researchers and clinicians to use genomic sequence to improve health care. The center uses state-of-the-art whole genome sequencing technologies within the Developmental and Neurogenetics Laboratory – Sequencing for clinical diagnoses and within its research portfolio to investigate how gene variants impact expression, define genetic variants associated with both rare and common disease, embryonic development, and the effects of environmental factors and drugs upon gene expression and disease. These studies are facilitated through gene engineering in animal models of human disease, bioinformatics resources including genome analysis tools, data standardization, and data integration of multiple data domains for both clinical human data and animal model research. The HMGC currently consists of 24 faculty members from both basic science (Physiology; Cell Biology, Neurobiology and Anatomy;Institute for Health and Society) and clinical departments (Pediatrics, Surgery, Medicine, and Obstetrics and Gynecology). This discovery research is well funded through NIH research grants and provides a superb training ground for young basic and clinical investigators.
The HMGC basic and clinical scientists lead the efforts at the Medical College of Wisconsin to provide quality precision medicine and health care by enabling researchers and clinicians to use genome sequence to understand disease, improve diagnosis and advance the treatment of our patients. Our Developmental and Neurogenetics Laboratory – Sequencing offers CLIA-certified whole exome and genome sequencing, robust data analysis and validation for precision diagnostics and therapeutics in pediatric and adult patients.
Programmatic areas of Human and Molecular Genetics Center members:
- Precision Medicine
- Genetics and Genomics
- Complex disease (cardiovascular, renal)
- Metabolic function
- Physiological Genomics
- Gene editing technologies
- Mutation detection technologies
- Sequencing, genotyping, expression profiling, biomarker development
- Genetic Counseling