Michael Olivier, PhD Associate Professor, Physiology Specialization: Genetics, Genomics, Proteomics Tel: (414) 456-4968 Dr. Olivier's CV Email: Click here
Our laboratory is trying to understand how genetic sequence variation affects gene function and ultimately human disease. We utilize genomics tools to discover single nucleotide polymorphisms (SNPs) by sequencing, genotype these SNPs in large numbers of individuals to understand patterns of linkage disequilibrium and haplotypes across extended regions of the human genome, analyze potential association of SNPs and haplotypes with complex human disorders, and explore the effect of haplotypes on gene expression and protein levels.
Our primary focus is on the metabolic syndrome, a disorder encompassing obesity, hyperlipidemia, insulin resistance, and hypertension. This common human syndrome often also leads to cardiovascular complications. As part of the Metabolic Risk Complications of Obesity Genes (MRC-OB) study at MCW, we are investigating genomic regions identified by linkage analysis in an attempt to use linkage disequilibrium and haplotype structure analysis to identify the causal gene(s) for alterations in the lipid profile such as elevated plasma triglyceride levels, or changes in HDL particle size distribution. In addition, we are focusing on candidate genes with known roles in metabolic pathways essential for glucose and lipid homeostasis.
In order to facilitate these efforts, we are developing novel tools and technologies to aid in our endeavors. As part of the NHLBI-funded National Proteomics Center at the Biotechnology and Bioengineering Center (http://proteomics.mcw.edu), we are developing efficient mass spectrometry-based experimental approaches to efficiently analyze and quantify the entire cellular proteome of vascular endothelial cells to identify proteomic changes during angiogenesis.
For more details on our laboratory and our projects, please click here.
Click here for Dr. Olivier's complete publications based on NCBI PubMed search.
Click here for Dr. Olivier's Faculty Collaboration Database profile page, which includes an up to date listing of his publications