Xiao Chen, M.D., Ph.D.
Assistant Professor of Medicine
Dr. Xiao Chen is Assistant Professor of Medicine at the Medical College of Wisconsin (MCW), Division of Hematology and Oncology. He obtained his medical degree from Fujian Medical University in China and his PhD degree in immunology from Technical University of Dresden in Germany. Dr. Chen came to the United States in 2001 and worked as a post-doctoral research fellow in the Department of Pediatric Surgery at MCW and was promoted to Research Scientist in 2004. He worked in the bone marrow transplantation program at MCW as a research scientist for several years, prior to joining the faculty in the Department of Medicine in 2010.
Dr. Chen's current research focuses on graft-versus-host disease (GVHD), which is a serious, frequently fatal complication following allogeneic hematopoietic stem cell transplantation. Specifically, he is investigating the role of retinoic acid in the pathophysiology of GVHD. This project is supported by prestigious Amy Strelzer Manasevit Research Award from the National Marrow Donor Program (NMDP). He also has a strong interest in tumor immunology and immunotherapy. His long term research goal is to find ways to augment the beneficial graft-versus-tumor (GVT) effect while minimizing GVHD in order to make allogeneic hematopoietic stem cell transplantation a more effective and safer treatment option for cancer patients.
Chen X*, Dodge J, Komorowski R, Drobyski WR. A critical role for the retinoic acid signaling pathway in the pathophysiology of gastrointestinal graft-versus-host disease. Blood 2013 (in press)
Doffek K, Chen X, Sugg S, Shilyansky J. Phosphatidylserine inhibits NFκB and p38 MAPK activation in human monocyte derived dendritic cells. Molecular Immunology 48: 1771-1777, 2011
Chen X, Das R, Komorowski R, Beres A, Hessner MJ, Mihara M, Drobyski WR. Interleukin 17 is not required for autoimmune-mediated pathological damage during chronic graft versus host disease. Biology of Blood and Marrow Transplantation 16: 123-128, 2010
Chen X, Das R, Komorowski R, Beres A, Hessner MJ, Mihara M, Drobyski WR. Blockade of interleukin-6 signaling augments regulatory T cell reconstitution and attenuates the severity of graft versus host disease. Blood 114:891-900, 2009
Das R, Chen X, Komorowski R, Hessner MJ, Drobyski WR. Interleukin-23 secretion by donor antigen- presenting cells is critical for organ-specific pathology in graft-versus-host disease. Blood 113: 2352-2362, 2009
Chen X, Vodanovic-Jankovic S, Johnson B, Keller M, Komorowski R, Drobyski WR. Absence of regulatory T-cell control of TH1 and TH17 cells is responsible for the autoimmune-mediated pathology in chronic graft-versus-host disease. Blood 110: 3804-3813, 2007
Gorski J, Chen X, Gendelman M, Yassai M, Krueger A, Tivol E, Logan B, Komorowski R, Vodanovic-Jankovic S, Drobyski WR. Homeostatic expansion and repertoire regeneration of donor T cells during graft versus host disease is constrained by the host environment. Blood 109: 5502-5510, 2007
Chen X, Doffek K, Sugg S, Shilyansky J. Phosphatidylserine regulates the maturation of human dendritic cells. Journal of Immunology, 173: 2985-2994, 2004