Laura Kresty, PhD
Associate Professor of Medicine
Laura Kresty, PhD is an Associate Professor of Medicine at the Medical College of Wisconsin (MCW), Division of Hematology and Oncology, specializing in Cancer Prevention. Dr. Kresty received her PhD in Public Health from The Ohio State University in 2000 with a major in Cancer Chemoprevention and Epidemiology and minor in Health Promotion and Disease Prevention. Dr. Kresty remained at The Ohio State University to complete a NCI-Sponsored Post-Doctoral Fellowship in Molecular Oncology, followed by a faculty appointment in Internal Medicine. In 2008, Dr. Kresty joined the University Of Miami Miller School Of Medicine and Sylvester Cancer where she continued her research focused on inhibition of esophageal and head and neck cancers. Dr. Kresty also served as Director for the Doctorate in Epidemiology Program and was a Cancer Biology Steering Committee Member at UM. Dr. Kresty joined the Medical College of Wisconsin in January, 2013, where she will continue research focused on the molecular biology, etiology, and inhibition of cancers of the esophagus and head and neck. Dr. Kresty serves as a peer reviewer for multiple journals in her field, has over 40 peer-reviewed research articles and book chapters, has delivered more than 35 invited talks throughout the world and serves on numerous NIH/NCI review and special emphasis panels. Ongoing research is focused on evaluating the cancer inhibitory potential of cranberry constituents, a novel HDAC inhibitor, vitamin D and investigating energy excess as it relates to esophageal adenocarcinoma risk. Our laboratory is also collaborating with Dr. Wax to investigate novel imaging technologies to detect early epithelial and sub-epithelial esophageal changes for more rapid evaluation of chemopreventive agents.
Kresty LA, Clarke J, Ezell K, Exum A, Howell AB, Guettouche T. MicroRNA alterations in Barrett's esophagus, esophageal adenocarcinoma, and esophageal adenocarcinoma cell lines following cranberry extract treatment: Insights for chemoprevention. J Carcinog, 10(34):66-82, 2011.
Kresty LA, Howell AB, and Baird M. Cranberry proanthocyanidins mediate growth arrest of lung cancer cells through modulation of gene expression and rapid induction of apoptosis. Molecules, 16:2375-2390, 2011.
Kresty LA, Exum A, and Zeyzus-Johns B. Berries in Cancer Prevention, Berries in the Prevention of Esophageal Adenocarcinoma Chapter 5, pp 101-115. Springer Publishing, New York, NY, 2011.
Kresty LA, Mallery SR, Knobloch TJ, Song H, Lloyd M, Zwick SL, Casto B, and Weghorst CM. Frequent alterations of p16INK4a and p14ARF in patients with proliferative verrucous leukoplakia. Cancer Epidemiology, Biomarkers and Prevention, 17(11):3179-87, 2008.
Shumway B, Kresty LA, Larsen P, Zwick J, Lu B, Fields H, Mumper R, Stoner G, Mallery S. Effects of a topically applied bioadhesive berry gel on loss of heterozygosity indices in premalignant oral lesions. Clin Cancer Research, 14: 2421-30, 2008.
Chalut KJ, Kresty LA, Pyhtila JW, Nines R, Baird M, Steele VE, and Wax A. In situ assessment of neoplastic transformation in hamster trachea epithelium using angle-resolved low coherence interferometry. Cancer Epidemiology, Biomarkers and Prevention, 16(2):223-7, 2007.
Kresty LA, Frankel WL, Hammond CD, Baird ME, Mele JM, Stoner GD, and Fromkes JJ. Transitioning from preclinical to clinical chemopreventive assessments of lyophilized black raspberries: Interim results show berries modulate markers of oxidative stress in Barrett’s Esophagus patients. Nutr & Cancer, 54(1), 148-156, 2006.