Hematology and Oncology

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Bin Ren, MD, PhDBin Ren, MD, PhD

Assistant Professor of Medicine

Dr. Bin Ren is an Assistant Professor of Medicine in the Division of Hematology and Oncology at the Medical College of Wisconsin (MCW). He is also a Research Scientist in Vascular Pathobiology Laboratory at Blood Research Institute in Blood Center of Wisconsin.

Dr. Ren received his bachelor of art degree from Anhui Normal University, his medical degree from Anhui Medical University (original Shanghai Southeast Medical College) and his doctoral degree from the University of Science and Technology of China. He has completed his postdoctoral Fellowship at Division of Cancer Biology and Angiogenesis, Beth Israel Deaconess Medical Center and Department of Pathology, Harvard Medical School. At Harvard he has served as key personnel on the NCI-funded Program Project entitled Spatial and Temporal Regulation of Angiogenesis.  Before joining the faculty of Medical College of Wisconsin, Dr. Ren was a research fellow at Division of Diabetes and Aging in Brookdale Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, and a research associate in the Angiogenesis Research Center, Department of Medicine, Pharmacology and Toxicology, Dartmouth College Medical School and in Lerner Research Institute, Cleveland Clinic Foundation. He has been working on endothelial cell and vascular biology for over 10 years. His work has been supported by NSFC, CAS and NIH, which results in over 20 peer reviewed publications including those in such high impact journals as Cancer Research, Journal of Clinical Investigation, Blood, and Biochimica et Biophysica Acta Review in Cancer. His work has been presented orally at AHA Scientific Sessions, the ATVB Annual Conference and FASEB Summer Meeting.

Dr. Ren has served as a member of the editorial board of Frontiers in Bioscience (USA), and Chinese Pharmacological Bulletin. He has also served as ad hoc reviewer for a number of prestigious biomedical journals. He has been invited to serve American Heart Association reviewer panel in the cardiovascular development since 2009. In 2010 he received Cell Biology’s Employee of the Quarter Award from Cleveland Clinic Foundation and Young Investigator Travel Award from American Heart Association. In 2011 he received the 1st Place of Elsa Albrecht RA/PS Award from Department of Cell Biology in Cleveland Clinic Foundation. In 2012 he received a national pilot award from American Cancer Society and a national SDG award from American Heart Association. His research interest focuses on epigenetic and transcriptional regulation of angiogenesis and arteriogenesis that is important in malignant tumors and cardiovascular diseases.
 

Selected Publications

  • Yiliang Chen, Devi Prasadh Ramakrishnan, *Bin REN. Regulation of Angiogenesis by Phospholipid Lysophosphatidic Acid. Frontiers in Bioscience (in press).
  • Bin REN, Hale J, Srikanthan S, *Silverstein RL. Lysophosphatidic acid suppresses endothelial cell CD36 expression and promotes angiogenesis via a PKD-1-dependent signaling pathway. Blood. 2011; 117(22):6036-45.
  • Hermans K, Claes F, Vandevelde W, Zheng W, Geudens I, Orsenigo F, De Smet F, Gjini E, Anthonis K, Bin REN, Kerjaschki D, Autiero M, Ny A, Simons M, Dewerchin M, Schulte-Merker S, Dejana E, Alitalo K, *Carmeliet P. Role of synectin in lymphatic development in zebrafish and frogs. Blood. 2010; 116(17):3356-66.
  • Bin REN, Yong Deng, Arpita Mukhopadhyay, Anthony A. Lanahan, Zhen W. Zhuang, Karen L. Moodie, Mary Jo Mulligan-Kerhoe1,  Tatiana V. Byzova, Randall T. Peterson, *Michael Simons. Erk1/2-Akt1 cross-talk-dependent regulation of arteriogenesis. Journal of Clinical Investigation, 2010; 120 (4):1217-28.
  • Bin REN, Keli Song, Sareh Parangi, Taiguang Jin, Min Ye, Robin Humphreys, Mark Duquette, Xuefeng Zhang, Nordine Benhaga, Jack Lawler, *Roya Khosravi-Far. A double hit to kill tumor and endothelial cells by TRAIL and antiangiogenic 3TSR. Cancer Research 2009; 69 (9): 3856–65.
  • Bin REN, Yee KO, Lawler J, *Khosravi-Far R. Regulation of Tumor Angiogenesis by Thrombospondin-1. Biochimica et Biophysica Acta 2006; 1765 (2): 178-188.
  • *Bin REN, Yuan WANG, Kenneth Ndebele, Qiang ZHI, Fuhu Chen, Yuzhen WANG, *Sareh Parangi. Multiple signaling is involved in apoptosis of endothelial cells induced by recombinant human endostatin. Frontiers in Bioscience 10, 2005; 1089-1097.
  • Lijia Bu, Yuan Wang, *Bin REN. Molecular mechanisms of angiogenesis & osteo tumorigenesis. Journal of Clinical Orthopaedics 2003; 6: 86-91 (Chinese).

Note: *corresponding author             

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