Hematology and Oncology

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Gary Stoner, Ph.D.

Professor of Medicine

Dr. Gary Stoner is Professor of Medicine at the Medical College of Wisconsin (MCW) Division of Hematology and Oncology, specializing in the fields of chemical carcinogenesis and cancer chemoprevention. He serves as Director of the Molecular Carcinogenesis and Chemoprevention Program in the newly developing Cancer Center.
Dr. Stoner received his PhD in microbiology from the University of Michigan in 1970 and became involved in cancer research as a post-doctoral fellow and research scientist at the University of California-San Diego (UCSD). While at UCSD, his research was focused on the development of a mouse model of lung cancer for the identification of environmental carcinogens and for mechanistic studies of lung carcinogenesis. He then joined the Laboratory of Human Carcinogenesis at the National Cancer Institute where he conducted research on the metabolism of tobacco carcinogens in human lung tissues and developed human lung cell culture systems for investigations of carcinogen/oncogene-induced cell transformation. He became involved in chemoprevention research in the early 1980’s while at the Medical College of Ohio, initially investigating the chemopreventive potential of naturally-occurring ellagitannins and isothiocyanates in the rodent lung and esophagus. As an extension of research with ellagic acid, Dr. Stoner’s laboratory developed a “food-based” approach to the prevention of esophagus and colon cancers in rodents and in humans using freeze-dried black raspberries. His research is documented in more than 350 peer-reviewed publications and book chapters, and he has edited several books.
Dr. Stoner joined MCW after nearly 20 years at the Ohio State University College of Medicine where he held the positions of Lucius Wing Endowed Chair in Cancer Research and Therapy, Associate Director for Basic Research and Director of the Chemoprevention Program in the Cancer Center, and Chair of the Division of Environmental Health Sciences and Associate Dean for Research in the College of Public Health. In addition, he served as Director of the Laboratory of Cancer Etiology and Chemoprevention in the Arthur James Cancer Hospital and Richard Solove Research Institute.
Dr. Stoner has served on several grant and contract review committees including the NIH Chemical Pathology Study Section, the NCI Cancer Biology and Immunology Contract Review Committee, and as Chair of the NIH Chemo/Dietary Prevention Study Section and the American Cancer Society Advisory Committee on Carcinogenesis, Environment and Nutrition. He has also served as President of the Carcinogenesis and Molecular Biology Specialty Sections of the American Society of Toxicology and of the Ohio Valley Society of Toxicology. He has received numerous awards including the NIH MERIT award, and the Distinguished Alumni Award and Honorary Doctorate from Montana State University. He is also a Fellow in the American Association for the Advancement of Science.

Selected Publications:
1. G.D. Stoner. Lung tumors in strain A mice as a bioassay for carcinogenicity of environmental   chemicals. Exp. Lung Res. 17:405-423, 1991.
2. G.D. Stoner and M. Paolino. Human tissue culture systems for studies of carcinogen metabolism and macromolecular interactions. In: Molecular Dosimetry and Human Cancer: Analytical, Epidemiological and Social Considerations, edited by John L. Groopman and Paul L. Skipper, CRC Press, pp. 105-130, 1991.
3. G.D. Stoner, M.A. Morse, and G. J. Kelloff. Perspectives in cancer chemoprevention. Environ. Health Perspect. 105:945-954, 1997.
4. B.W. Liston, A. Gupta, R. Nines, P.S. Carlton, L.A. Kresty, G.K. Harris and G.D. Stoner. Incidence and effects of Ha-ras codon 12 G->A transition mutations in preneoplastic lesions induced by N-nitrosomethylbenzylamine (NMBA) in the rat esophagus. Molecular Carcinogenesis, 32:1-8, 2001.
5. L.A. Kresty, M.A. Morse, C. Morgan, P.S. Carlton, J. Lu, A. Gupta, M. Blackwood and G.D. Stoner Chemoprevention of esophageal tumorigenesis by dietary administration of lyophilized black raspberries. Cancer Res., 61:6112-6119, 2001.
6. C. Huang, J. Li, L. Song, D. Zhang, Q. Tong, M. Ding, L. Bowman, R. Aziz and G.D. Stoner. Black raspberry extracts inhibit benzo(a)pyrene diol-epoxide-induced activator protein 1 activation and vascular endothelial growth factor transcription by targeting the phosphotidylinositol 3-kinase/Akt pathway. Cancer Res. 66:581-588, 2006.
7. G.D. Stoner, A. Dombkowski, R.K. Reen, D. Cukovic, S. Salagrama, L-S. Wang, L-S and J.F. Lechner Carcinogen-altered genes in rat esophagus positively modulated to normal levels of expression by both phenethyl isothiocyanate and black raspberries. Cancer Res. 68:6460-64, 2008.
G.D. Stoner. Foodstuffs for cancer prevention: The preclinical and clinical development of berries. Cancer Prev. Res. 2:187-92, 2009.
8. L-S Wang, M. Arnold, C. Seguin, C. Sardo, Y-W. Huang, E. Martin, T. H-M. Huang, C. Henry, C. Rocha, K. Stoner, K. Riedl, S. Schwartz, W. Frankel, D. Pearl, A. Buchta, Y. Xu, J. Winston III, Jr. and G.D. Stoner. Modulation of genetic and epigenetic biomarkers of colon cancer in humans by black raspberries: A phase I pilot study (In press, Clin Cancer Res).



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