Hematology and Oncology

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Li-Shu Wang, PhDLi-Shu Wang, PhD

Assistant Professor of Medicine

Dr. Li-Shu Wang is an Assistant Professor of Medicine in the Division of Hematology and Oncology at the Medical College of Wisconsin (MCW). Her research interests are in the fields of chemical carcinogenesis and cancer chemoprevention.
Dr. Wang received her PhD in Veterinary Biosciences from Ohio State University where her research was focused on illustrating the mechanisms of conjugated linoleic acid, naturally occurring compounds, in the prevention of breast cancers. Afterward, she continued involved in cancer prevention research as a post-doctoral fellow and research scientist at the same university. During her post-doctoral training, her research was focused on the prevention of gastrointestinal cancers using berries, their active components and metabolites. Her research is documented in more than 45 peer-reviewed publications and book chapters.
Dr. Wang has received numerous awards including scholar-in-training award of American Association for Cancer Research (AACR) prevention meeting, and IAMS research funds. She is a reviewer for several publications including but not limited to Cancer Research, Clinical Cancer Research, Cancer Epidemiology, and Biomarkers & Prevention.


Selected Publications:
1. Wang LS, Hecht SS, Carmella SG, Yu N, Larue B, Henry C, McIntyre C, Rocha C, Lechner JF, Stoner GD. Anthocyanins in black raspberries prevent esophageal tumors in rats. Cancer Prev Res 2009; 2:84-93.
2. Huang YW, Huang TH, Wang LS. Profiling DNA methylomes from microarray to genome-Scale sequencing. Technol Cancer Res Treat 2010;9:139-47.
3. Huang YW, Kuo CT, Stoner K, Huang TH, Wang LS. Overview of epigenetics and chemoprevention. FEBS Letters 2011;50:291-300.
4. Wang LS, Hecht SS, Carmella SG, Seguin C, Rocha C, Yu N, Stoner K, Chiu S, Stoner GD. Berry ellagitannins may not be sufficient for prevention of tumors in the rodent esophagus. J Agric Food Chem 2010;58:3992-5.
5. Wang LS, Arnold M, Huang YW, Sardo C, Seguin C, Martin E, Huang TH, Riedl K, Schwartz S, Frankel W, Pearl D, Xu Y, Winston J 3rd, Yang GY, Stoner GD. Modulation of Genetic and Epigenetic Biomarkers of Colorectal Cancer in Humans by Black Raspberries: A Phase I Pilot Study. Clin Cancer Res 2011; 17:598-610.

6. Wang LS, Kuo CT, Huang YW, Stoner GD, Lechner JF. Gene-diet interactions on colorectal cancer risk. Curr Nutr Rep 2012;1:132-41.

7. Wang LS, Kuo CT, Cho SJ, Seguin C, Siddiqui J, Stoner K, Weng YI, Huang TH, Tichelaar J, Yearsley M, Stoner GD, Huang YW. Black raspberry-derived anthocyanins demethylate tumor suppressor genes through the inhibition of DNMT1 and DNMT3B in colon cancer cells. Nutr Cancer 2013;65:118-25.

8. Wang LS, Kuo CT, Huang TH, Yearsley M, Oshima K, Stoner GD, Yu J, Lechner JF, Huang YW. Black raspberries protectively regulate methylation of Wnt pathway genes in precancerous colon tissue. Cancer Prev Res 2013;6:1317-27.

9. Wang LS, Kuo CT, Stoner K, Yearsley M, Oshima K, Yu J, Huang TH, Rosenberg D, Peiffer D, Stoner G, Huang YW. Dietary black raspberries modulate DNA methylation in dextran sodium sulfate (DSS)-induced ulcerative colitis. Carcinogenesis 2013;34:2842-50.

10. Wang LS, Burke CA, Hasson H, Kuo CT, Molmenti CL, Seguin C, Liu P, Huang TH, Frankel WL, Stoner GD. A Phase 1b Study of the Effects of Black Raspberries on Rectal Polyps in Patients with Familial Adenomatous Polyposis. Cancer Prev Res 2014;7:666-74.

 

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