MCW Research News – Basic Sciences

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Biophysics researchers publish paper identifying novel inhibitors of NADPH oxidase enzymes

Feb. 11 - Drs. Balaraman Kalyanaraman, chairman and professor of biophysics and Harry R. & Angeline E. Quadracci Professor in Parkinson’s Research, and Jacek Zielonka, research director of the Free Radical Research Center in the department of biophysics, recently published an article in the Journal of Biological Chemistry describing ways with which inhibitors of NADPH oxidase enzyme 2 (Nox2 isoform) are identified.

Drs. Candice Klug & Kathryn Schultz author paper published in Science

Feb. 9 - Candice Klug, PhD, professor of biophysics, and Kathryn Schultz, PhD, research scientist, are authors on a paper published in Science on Feb. 5 on the structure of a bacterial enzyme responsible for conferring resistance to polymyxin, an antibiotic used to treat infections. The paper represents collaborative research between MCW’s department of biophysics and Columbia University.

MCW’s animal care program receives continued full accreditation, called “exemplary”

Jan. 21 - The Medical College of Wisconsin (MCW) animal care program has received continued full accreditation from the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) International. AAALAC commended MCW in its final report “for providing and maintaining an exemplary program of laboratory animal care and use,” and had no further recommendations to offer for improvement.

MCW professor receives grant for genetic research on obesity

Dec. 11 - The Medical College of Wisconsin (MCW) has received a four-year, $2.6 million grant from the National Institutes of Health’s (NIH) National Institute of Diabetes and Digestive Kidney Diseases to investigate the underlying genetic mechanisms of obesity.

Graduate student aims at brain research

Using technology and tools that the Medical College of Wisconsin was a world leader in developing, a PhD student in the Graduate School of Biomedical Sciences and her faculty mentor are pursuing brain research with potential to benefit cancer patients.

Gut studies hold promise for prevention

Medical College of Wisconsin researchers are studying intestinal bacteria as a promising new approach for the prevention of heart attacks and a range of other conditions, including pediatric liver disease and antibiotic-resistant, hospital-acquired infections.

Pioneering eye care benefits generations

A landmark advance more than 35 years ago has improved vision dramatically for thousands of patients with diabetic eye disease. Today, vision research at the Froedtert & the Medical College of Wisconsin Eye Institute seeks to actually prevent retinal eye disease.

Baldwin looks to boost NIH-funded research

Oct. 20 - Senator Tammy Baldwin conducted a roundtable session at the Medical College on October 14 seeking feedback from about two dozen MCW researchers, ranging from graduate students to department chairs, regarding a bipartisan bill, the Next Generation Research Act. Wisconsin Business

Jeffrey A. Medin, PhD, named MACC Fund Endowed Professor

Sept. 24 - Jeffrey A. Medin, PhD, has been named the MACC Fund Professor in the department of pediatrics at the Medical College of Wisconsin (MCW). Dr. Medin currently serves as a professor in the department of medical biophysics and the institute of medical science, faculty of medicine, at the University of Toronto in Ontario, Canada.

MCW scientist to study novel regulatory mechanisms for a gene involved in vascular anomalies

Aug. 3 - The Medical College of Wisconsin (MCW) has received a four-year, $1.8 million dollar grant from the National Institutes of Health’s National Heart, Lung and Blood Institute to study the RNA regulatory mechanisms underlying genes involved in vascular anomalies.

MCW scientist receives grant to train postdoc fellows for research careers in academic gastroenterology

July 21 - The Medical College of Wisconsin (MCW) has received a five-year, $664,000 grant from the National Institutes of Health’s National Institute of Diabetes and Digestive and Kidney Diseases to continue the Gastroenterology Postdoctoral Research Training Program for 10 postdoctoral fellows interested in a research career in academic gastroenterology.

Dr. Imig Expects Companies to Invest in Drugs Targeted to Gene Mutations

July 13 - John Imig, PhD, (Pharmacology & Toxicology) tells International Business Times that he expects the debut of the PCSK-9 inhibitors (which targets a mutation in the PCSK-9 gene, which causes high cholesterol) will spur companies to invest in this area as scientists continue their search for genetic factors underlying major diseases. International Business Times

Dr. Qizhen Shi receives Bayer Hemophilia Award

June 23 - Qizhen Shi, MD, PhD, associate professor of pediatrics (hematology/oncology), was one of 17 investigators from around the world to receive a grant as part of the Bayer Hemophilia Award Program (BHAP). Dr. Shi received the award during the International Society on Thrombosis and Haemostasis Congress in Toronto for his research on platelet gene therapy of Murine Hemophilia B with inhibitors.

Imagine More Dinner to raise funds for neuroscience research

May 13 - The third annual Imagine More Dinner to support neuroscience research at the Medical College of Wisconsin (MCW) Neuroscience Research Center will be held Sunday, June 28, at the Wisconsin Club, 900 W. Wisconsin Avenue in Milwaukee. Previously called the Park Dinner, the event has been renamed to reflect the spirit of hope and innovation.

Double teaming fight against childhood cancer

June 16 - Teamwork builds champions. Teamwork also helps save the lives of children with cancer. At least this is the case for a pair of MACC Fund Center researchers – one a scientist the other a clinician -- who make up an amicable and very likeable pair who have teamed up for the past five years to champion an initiative harnessing the power of one’s own natural immune system to fight childhood cancer.

The secrets of bone marrow: What leads to healthy blood cell production?

June 12 - The Medical College of Wisconsin (MCW) has received a five-year, $635,000 grant from the National Institutes of Health’s National Heart, Lung and Blood Institute to identify new potential treatments for diseases that inhibit the growth of blood cells and diseases in which the blood cells develop abnormally.

WBCS, Inc. to fund three breast cancer researchers

May 29 - Three researchers at the Medical College of Wisconsin (MCW) have each received a two-year, $100,000 grant from WBCS, Inc. (Wisconsin Breast Cancer Showhouse) to study cancer risks and potential new therapies.

AHA Awards MCW $3.7 Million for National Hypertension Research Center

May 27 - The American Heart Association (AHA) awarded MCW a four-year, $3.7 million grant to create a Strategically Focused Hypertension Research Center. MCW is one of four research centers nationwide that will form the AHA’s national hypertension network. Waukesha Now

Wound healing research part of MCW/VA collaboration

May 19 - The Medical College of Wisconsin and the Clement J. Zablocki VA Medical Center are collaborating to improve our understanding of small blood vessel function on wound healing. Veterans are at risk for chronic wounds that lead to amputation.

Dr. Flister Receives $1.75 Million NCI Grant to Study Factors that Impact Breast Cancer Risk

May 13 - Michael Flister, PhD, (Physiology) received a five-year, $1.75 million grant from the National Cancer Institute to identify factors in the microenvironment of tumors that impact breast cancer risk. The goal of this project is to develop a new genetic model to assess breast cancer risk in the tumor microenvironment. Milwaukee Journal Sentinel

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