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MCW Research News - Basic Sciences

Family holds out hope for a cure for a rare genetic disorder

Apr 10 - Research at the Children’s Hospital of Wisconsin Research Institute and MCW is providing hope for families with children with rare muscular disease. WTMJ-TV

TOPS Club Commits $205,000 for Obesity Research

Apr 8 - TOPS Club, Inc., a Milwaukee-based weight loss organization, has committed $205,000 toward MCW research obesity and metabolic disorders. BizTimes

Dr. Stucky and Scripps Colleagues Identify Factors Creating Sensation of Touch

Apr 8 - Cheryl Stucky, PhD, and collaborators at the Scripps Research Institute published a study in Nature that identified a dual-sensor system involving the Merkel cell and an associated nerve end that contribute to the touch sensation. Medical Express

Dr. Prokop Co-Authors Study on the Discovery of a Missing Hormone in Birds

Apr 3 - Jeremy Prokop, PhD, collaborated with lead authors at the University of Akron who were the first to discover leptin in birds. BrightSurf.com

Dr. Ebert Receives Families of Spinal Muscular Atrophy Grant

Feb 25 - Families of Spinal Muscular Atrophy announced that Allison Ebert, PhD, is one of eight scientists worldwide who will share in $600,000 in basic science research awards to study the disorder. Families of SMA

Dr. Duncan Provides Comment on New Process to Shortcut Skin-to-Liver Cell Reprogramming

Feb 25 - Stephen Duncan, PhD, provides expert comment in The Scientist on a research study reported in Nature that researchers at University of California San Francisco have adapted a reprogramming technique that speeds the process of converting skin cells to liver cells. The Scientist

Understanding bacteria’s resistance to antibiotics may lead to better treatments

Feb. 21 - The Medical College of Wisconsin (MCW) has received a two-year $378,000 grant from the National Institutes of Health’s National Institute of Allergy and Infectious Diseases to study the mechanisms underlying drug resistance in bacteria.

Gut studies hold promise for prevention

Medical College of Wisconsin researchers are studying intestinal bacteria as a promising new approach for the prevention of heart attacks and a range of other conditions, including pediatric liver disease and antibiotic-resistant, hospital-acquired infections.

Graduate student aims at brain research

Using technology and tools that the Medical College of Wisconsin was a world leader in developing, a PhD student in the Graduate School of Biomedical Sciences and her faculty mentor are pursuing brain research with potential to benefit cancer patients.

Genetics team to create hundreds of new knockout rats to study human disease

Feb. 13 - The Medical College of Wisconsin has received a five-year, $8.7 million grant from the National Institutes of Health’s National Heart, Lung and Blood Institute to create 200 gene-targeted rat models to study the genetics of human disease.

Dr. Kim Receives $1.2 Million NIH Grant to Study How the Body Metabolizes Drugs

Feb 12 - Jung-Ja Kim, PhD, received a four-year, $1.2 million grant from the National Institute of General Medical Sciences to study the way in which the human body metabolizes drugs, and the causes behind abnormal steroid hormone production. WauwatosaNOW

Researchers Find Two Distinct Patterns of Genetic Alteration in Invasive Bladder Cancer

Feb 6 - MCW researchers are co-authors of a Roswell Park Cancer Institute-led study reported in the Proceedings of the National Academy of Sciences that found that invasive bladder cancers demonstrate two distinct patterns of genetic alteration, one of which may result from defects in cells' ability to replicate. Medical News Today

Researcher to investigate mechanics of drug metabolism

Feb. 03 - The Medical College of Wisconsin (MCW) has received a four-year, $1.2 million grant from the National Institutes of Health’s National Institute of General Medical Sciences to study the way in which the human body metabolizes drugs, and the causes behind abnormal steroid hormone production.

Pioneering eye care benefits generations

A landmark advance more than 35 years ago has improved vision dramatically for thousands of patients with diabetic eye disease. Today, vision research at the Froedtert & the Medical College of Wisconsin Eye Institute seeks to actually prevent retinal eye disease.

“Metamorphic” protein could lead to new AIDS-fighting drugs

Dec. 26 - The Medical College of Wisconsin (MCW) has received a one-year, $353,000 grant from the National Institutes of Health’s National Institute of Allergy and Infectious Diseases (NIAID) to study a unique protein that shows promise as an HIV inhibitor.

New 7T GE MRI scanner will advance cutting-edge neuroscience research

Dec. 11 - A 42-ton 7T magnet arrived at the Medical College of Wisconsin’s Center for Imaging Research on Dec. 5. It will be the centerpiece of a new, powerful Magnetic Resonance Imaging (MRI) scanner designated for cutting-edge neuroscience research.

Thirty years of undergraduate research training

The Summer Program in Undergraduate Research (SPUR) has given college students direct experience in MCW laboratories for 30 years, building a pipeline for future scientists.

Gene Therapy Successfully Treats Hemophilia in Dogs

Nov 20 - Dogs with hemophilia, a bleeding disorder, were successfully treated by gene therapy. BBC

New genetic cause of Warburg Micro Syndrome identified

Nov. 18 - A collaborative team of researchers led by researchers at the Medical College of Wisconsin and the University of Edinburgh has identified a gene responsible for Warburg Micro syndrome, a rare genetic disease characterized by eye, brain and endocrine abnormalities. Patients with Warburg Micro syndrome are severely physically and mentally challenged, unable to learn how to walk or speak and become blind and paralyzed from an early age.

Graduate Student Receives NIH Grant to Study Science of Diabetes at a Cellular Level

Nov 12 - Megan Detterman received a six-year, $266,000 grant from the National Institute of Diabetes and Digestive and Kidney Diseases to study the science of diabetes at a cellular level. WauwatosaNOW

Dr. Sorokin Receives $1.3 Million NIH Grant to Study Actions of Protein in Kidney Disease

Nov 8 - Andrey Sorokin, PhD, received a $1.3 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases to study actions of protein called endothelin-1 in the progression of glomerular kidney diseases. WauwatosaNOW

MACC Fund energizes MCW cancer research

Oct. 30 - Teamwork is in the DNA of the MACC Fund (Midwest Athletes Against Childhood Cancer, Inc.), which engages thousands of volunteers and donors in its mission to help kids with cancer and was founded, incidentally, during halftime of a Milwaukee Bucks game. Teamwork is also at the heart of the research the MACC Fund supports, which succeeds through the powerful partnership of the Medical College of Wisconsin (MCW) and Children’s Hospital of Wisconsin.

Dr. Sood Received $1.5 Million NIH Grant to Study Blood Coagulation Abnormalities

Oct 29 - Rashmi Sood, PhD, received a four-year, $1.5 million grant from the National Heart, Lung, and Blood Institute to study abnormalities in blood coagulation that affect women’s health and pregnancy. Wisconsin Health News

Researcher to study causes of kidney disease

Oct. 29 - The Medical College of Wisconsin (MCW) has received a four-year, $1.3 million grant from the National Institutes of Health’s National Institute of Diabetes and Digestive and Kidney Diseases to study actions of protein called endothelin-1 (ET-1) in the progression of glomerular kidney diseases.

Researchers strive to save sight of preemies

Oct. 28 - It is estimated that one in every 100 children who enter the neonatal intensive care unit at birth will go blind due to a disease called retinopathy of prematurity (ROP). Aided by a $300,000 grant from the Russell J. and Betty Jane Shaw Fund of the Greater Milwaukee Foundation, Medical College of Wisconsin researchers are trying to save the sight of infants with ROP before they go blind.

Noah Leigh receives Poster Award at international conference

Oct. 24 - Noah Leigh, Research Associate in Dr. Ramani Ramchandran's lab, received 1st Place for the poster he presented at the 1st Zebrafish for Personalized & Precision Medicine Conference held in Toronto earlier this month. The poster is titled, Mmp17b is essential for proper neural crest cell migration in vivo.

Dr. Semina Receives NIH Grant to Study Genes Associated with Pediatric Cataracts

Oct 22 - Elena V. Semina, PhD, received a two-year, $412,500 grant from the National Eye Institute to study the genes associated with pediatric cataracts. WauwatosaNOW

Genetic sequencing to identify causes of pediatric cataracts

Oct. 17 - The Medical College of Wisconsin received a two-year, $412,500 grant from the National Institutes of Health’s National Eye Institute to study the genes associated with pediatric cataracts.

The space-time relativity of intracellular signaling

Oct. 08 - The Medical College of Wisconsin (MCW) has received a four-year, $1.5 million grant from the National Institutes of Health’s National Institute of Allergy and Infectious Diseases to study lymphocytes, the body’s “natural killer” cells, and determine the signaling pathways that elicit disease-fighting responses at a cellular level in the body.

Dr. Brandow Receives $696,000 NIH Grant to Study Pain in Sickle Cell Disease

Oct 8 - Dr. Amanda Brandow received a five-year, $696,000 grant from the National Heart, Lung, and Blood Institute to study the mechanisms of pain in sickle cell disease. WauwatosaNOW

Dr. Malarkannan Receives $1.5 Million NIH Grant to Study Signaling Pathways in Lymphocytes

Oct 8 - Subramaniam Malarkannan, PhD, received a four-year, $1.5 million grant from the National Institute of Allergy and Infectious Diseases to study lymphocytes and determine the signaling pathways that elicit disease-fighting responses at a cellular level in the body. WauwatosaNOW

Researcher to explore causes of pain in sickle cell disease

Oct. 03 - The Medical College of Wisconsin and the Children’s Hospital of Wisconsin Research Institute have received a five-year, $696,000 grant from the National Institutes of Health’s National Heart, Lung and Blood Institute (1K23HL114636-01A1) to study the mechanisms of pain in sickle cell disease.

Dr. Clifford Provides Career Planning Advice for Graduate Students, Postdoctoral Fellows

Sept 30 - Philip Clifford, PhD, co-authored an article in Science offering career planning advice for graduate students and postdoctoral fellows. American Association for the Advancement of Science

Dr. Cowley Discusses Computing Support Provided to College through the Milwaukee Institute

Sept 30 - Allen Cowley, Jr., PhD, describes the beneficial impact on MCW research provided by the Milwaukee Institute, which provides MCW with high-performance computing systems and storage infrastructure. WisBusiness.com, Milwaukee Business Journal, Milwaukee Journal Sentinel

Dr. Kerschner Joins Senator Baldwin to Discuss Importance of Next Generation Research Act

Sept 30 - Dr. Joseph E. Kerschner joined U.S. Senator Tammy Baldwin in a Google Hangout to discuss the importance of Senator Baldwin’s proposed Next Generation Research Act. Youtube.com

Dr. Cowley Receives $9.5 Million NIH Grant to Study Links between Peroxide and Hypertension

Sept 30 - Allen Cowley, Jr., PhD, received a five-year, $9.5 million grant from the National Heart, Lung, and Blood Institute to study the role of hydrogen peroxide in the development of salt-sensitive hypertension. WauwatosaNOW

Antioxidants, stress and hypertension: researchers seek answers to fundamental questions

Sept. 27 - The Medical College of Wisconsin (MCW) has received a five-year, $9.5 million grant from the National Institutes of Health’s National Heart, Lung and Blood Institute to study the role of hydrogen peroxide in development of salt-sensitive hypertension.

Sen. Baldwin at MCW to Share Proposal for Legislation to Streamline NIH Support

Aug 27 - In a meeting with MCW faculty members, students, administrators and Wisconsin business leaders, U.S. Senator Tammy Baldwin announced she will be introducing legislation to streamline NIH support for young investigators. Milwaukee Business Journal, Milwaukee Journal Sentinel, & Green Bay Press-Gazette

Alumni/Students/Patients in Wisconsin

Wisconsin map of Alumni, Students and Patients

Understanding the eye: researchers to explore vision at the cellular level

Sept. 10 - The Medical College of Wisconsin (MCW) has received a four-year, $2 million grant from the National Institutes of Health’s National Eye Institute to study the causes and progression of eye diseases at the cellular level.

New diagnostics to detect lung injury

Aug 29 - The Medical College of Wisconsin (MCW) has received a four year, $1.07 million grant from the National Institutes of Health’s National Heart, Lung, and Blood Institute to evaluate new non-invasive methods to detect lung injury.

Senator Baldwin Opposes Proposed Cuts to Medicare Reimbursements for Rural Hospitals

Aug 28 - A photo of Dr. John R. Raymond, Sr., and U.S. Senator Tammy Baldwin appears in the Gannett Newspaper chain’s Fox Valley newspapers accompanying an article on Senator Baldwin’s fight against proposed cuts to Medicare reimbursements for rural hospitals. fdlreporter.com

Dr. Forster Receives $1.45 Million NIH Grant to Study Neural Control of Respiration

Aug 28 - Hubert Forster, PhD, received a $1.45 million grant from the National Heart, Lung, and Blood Institute to study the neural control of respiration. WauwatosaNOW

Dr. Clifford Stresses the Value of Informational Interviews for Young Scientists

Aug 27 - Philip S. Clifford, PhD, authored an article in Science Careers on the value of informational interviews for young scientists as they begin their careers. Science Careers

Dr. Jackson Discusses the Importance of Public Funding for Biomedical Research

Aug 27 - A Huffington Post article on the challenges created by sequestration focuses on the research conducted by William Jackson, PhD. Huffington Post

Developing new therapeutic targets for psoriasis

Aug 21 - The Medical College of Wisconsin (MCW) has received a five year, $1.6 million grant from the National Institutes of Health’s National Institute of Arthritis and Musculoskeletal and Skin Diseases to study the development of psoriasis, and to evaluate molecules that have the potential to prevent psoriatic symptoms and that could be models for drug development.

fMRI study documents brain activation during concussion recovery

Aug 20 - For the first time, researchers have documented irregular brain activity within the first 24 hours of a concussive injury, as well as an increased level of brain activity weeks later—suggesting that the brain may compensate for the injury during the recovery time.

Sen. Baldwin Warns of Lost Generation of Science Researchers

Aug 15 - Senator Tammy Baldwin visited MCW to discuss a bill she is proposing called The Next Generation Research Act, which would establish an NIH initiative to direct efforts to promote new researchers in the sciences. Milwaukee Journal Sentinel

Sequestration Ushers in a Dark Age for Science in America

Aug 15 - A Huffington Post article explores the impact of sequestration on scientists in the U.S. The article highlights research conducted by William Jackson, PhD, assistant professor of microbiology and molecular genetics. Huffington Post

It works, but how? Researchers to study mechanisms of anesthesia

Aug 15 - The Medical College of Wisconsin (MCW) has received a four year, $1.3 million grant from the National Institutes of Health’s National Institute of General Medical Sciences to study how anesthesia works to suppress consciousness, and how consciousness returns.

Dr. Jackson Receives $360,000 NIH Grant to Study How Polioviruses Become Infectious

Aug 2 - William Jackson, PhD, received a one-year, $360,000 grant from the National Institute of Allergy and Infectious Diseases to study the ways in which polioviruses replicate and become infectious. WauwatosaNOW

Dr. Kim Receives $1.5 Million NIH Grant to Study Enzymes involved in Fatty Acid Oxidation

May 1 - Jung-Ja Kim, PhD, received a four-year, $1.5 million grant from the National Institute of General Medical Sciences to study the structure and function of enzymes involved in fatty acid oxidation. WauwatosaNOW

$6 million grant funds National EPR Center

May 15 - The National Biomedical Electron Paramagnetic Resonance (EPR) Center at the Medical College of Wisconsin (MCW) has received a five-year, $6 million renewal grant from the National Institute of Health’s National Institute of Biomedical Imaging and Bioengineering. The EPR Center was established in 1976, and has been continuously funded since. It is classified as a Biomedical Technology Resource Center, and is one of eight federally-designated research centers at MCW.

05.02 - College to honor National VA Research Week May 2-6

The week of May 2-6 is VA Research Week, and the Medical College of Wisconsin will be observing the event with a series of articles and a variety of displays that highlight the research collaboration between the College and the Clement J. Zablocki VA Medical Center.

05.04 - Dr. Ravi Misra named Dean of Graduate School of Biomedical Sciences

The Medical College of Wisconsin has named Ravi P. Misra, PhD, Professor of Biochemistry at the Medical College, as Dean of the College’s Graduate School of Biomedical Sciences. Dr. Misra’s appointment was announced by T. Michael Bolger, JD, President and CEO. Dr. Misra assumed his new position on May 1.

07.14 -NIH grant supports Milwaukee-wide research partnership

The National Institutes of Health (NIH) announced today it has awarded a $20 million grant to The Medical College of Wisconsin, representing a consortium of eight Milwaukee institutions to create a Milwaukee-wide research partnership that shares a common vision, resources and staff to advance biomedical research, patient care and education.

Antioxidant shows promise in Parkinson’s disease

Jun 19 - Diapocynin, a synthetic molecule derived from a naturally occurring compound (apocynin), has been found to protect neurobehavioral function in mice with Parkinson’s disease symptoms by preventing deficits in motor coordination.

Beating Heart Cells

Beating Heart Cells - Induced pluripotent stem cells from adults, not embryos, are converted into beating heart cells and used for research at The Medical College of Wisconsin by John Lough, Ph.D. and Ulrich Broeckel, M.D.

Brain and spinal cord Injury research programs at VA

May 14 - The Medical College of Wisconsin and the Clement J. Zablocki VA Medical Center are collaborating to improve the lives of those with traumatic brain injuries and spinal cord injuries.

Cancer Center scientists’ discovery in cancer metastasis featured on cover of Science Signaling

Jun 25 - MCW cancer researcher Carol L. Williams, PhD, and her research team have identified a way to block receptors that might be responsible for signaling lung, breast, and pancreatic cancer metastasis. This work, including a cover picture of cancer cells moving away from each other when the receptors are active, was published in the May 28th issue of Science Signaling.

College to honor National VA Research Week May 13-17

May 13 - The week of May 13-17 is VA Research Week, and the Medical College of Wisconsin will be observing the event with a series of articles that highlight the research collaboration between the College and the Clement J. Zablocki VA Medical Center.

Development of ACE inhibitors to treat radiation injury

Jun 25 - The Medical College of Wisconsin (MCW) has received a five year, $2.6 million grant from the National Institutes of Health’s National Institute of Allergy and Infectious Diseases to develop the use of an ACE inhibitor, lisinopril, to mitigate radiation injuries in multiple organs.

Dr. Hessner Receives NIH Grant to Develop Assay to Detect Type 1 Diabetes

May 7 - Martin J. Hessner, PhD, received a three-year, $857,000 grant from the National Institute of Diabetes and Digestive and Kidney Diseases to continue to develop an assay shown to detect inflammation linked to the development of Type 1 diabetes before patients are symptomatic. WauwatosaNOW

Dr. Mattson Receives $1.7 Million NIH Grant for Hypertension, Kidney Disease Research

June 3 - David Mattson, PhD, received a five-year, $1.7 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases to study the role of immune cells in the development of hypertension and kidney disease. WauwatosaNOW

Final Vision Science Distinguished Lecture planned for April 22

Apr 18 - The Department of Ophthalmology is presenting the final Vision Science Distinguished Lecture of the 2012-2013 series on Monday, April 22, from 12-1 p.m. in the lower level of the Froedtert & The Medical College of Wisconsin Eye Institute. Jeffrey L. Goldberg, MD, PhD, Professor of Ophthalmology and Director of Research at the Shiley Eye Center at the University of California – San Diego, will give a presentation titled, Retinal Ganglion Cell Survival and Regeneration.

Impact of Sequestration on MCW

March 12 - Sequestration will force $5-9 million in federal funding cuts to MCW. Milwaukee Journal Sentinel & The Badger Herald

MCW researcher to focus on blood clot prevention

Jul 01 - The Medical College of Wisconsin has received a four year, $1.5 million grant from the National Institutes of Health’s National Heart, Lung and Blood Institute to study a protein associated with thrombosis, or blood clots. Thrombosis is the leading cause of morbidity and mortality in the United States.

Medical College researcher to study immune cell role in hypertension and kidney disease

June 05 - The Medical College of Wisconsin received a five-year, $1.7 million grant from the National Institutes of Health’s National Institute of Diabetes and Digestive and Kidney Diseases to fund an investigation of the role of immune cells in the development of hypertension and kidney disease.

National Center for Systems Biology to be established at Medical College

Aug. 11 - The Medical College of Wisconsin has received a five-year, $13 million grant to establish a National Center for Systems Biology.

Neuroscience Research Center requests proposals for pilot grants

May 03 - The Neuroscience Research Center plans to fund four categories of pilot grants to enhance research capacity in the area of neuroscience research. The largest awards will fund collaborative projects involving two or three faculty members.

Predicting type 1 diabetes at a molecular level

May 03 - The Medical College of Wisconsin and Children’s Hospital of Wisconsin Research Institute received a three-year, $857,000 grant from the National Institutes of Health’s National Institute of Diabetes and Digestive and Kidney Diseases to continue to develop an assay shown to detect inflammation linked to the development of Type 1 diabetes (T1D) before patients are symptomatic.

Researcher to investigate enzymes involved in fatty acid oxidation

Apr 25 - The Medical College of Wisconsin received a four-year, $1.5 million award from the National Institute of General Medical Sciences, National Institutes of Health to study the structure and function of enzymes involved in fatty acid oxidation.

Researcher to study Lou Gehrig’s Disease

Sept 14 - The Medical College of Wisconsin has received a $40,000 grant from the ALS Association’s Jeff Kaufman Fund to study the impact of skeletal muscle on the progression of ALS, or Lou Gehrig’s Disease, as it’s commonly known.

Researcher to study main complication after bone marrow transplantation

Jul 09 - The Medical College of Wisconsin (MCW) has received a four year, $1.5 million grant from the National Institutes of Health’s National Heart, Lung and Blood Institute to study graft versus host disease (GVHD), the major complication associated with bone marrow transplants.

Researchers to study socioeconomic factors in breast cancer mortality rates

May 07 - The Medical College of Wisconsin (MCW) has received a $1.1 million, three year grant from the National Institutes of Health National Cancer Institute to study socioeconomic disparities in breast cancer outcomes.

Sean Scherer, M1, receives AGA Student Fellowship Award for research on CVS

May 14 - Sean Scherer, a first year medical student at the Medical College of Wisconsin (MCW), has been awarded the 2013 American Gastroenterological Association’s Student Research Fellowship Award. This award provides monetary support for students in the hope of stimulating interest in careers pertaining to digestive diseases.

Survival Takes Guts: Bacteria There Might Affect Heart Attack

June 25 - John Baker, PhD, discusses his research linking the gut’s microbiome with heart attack risk and severity in the Milwaukee Journal Sentinel. Milwaukee Journal Sentinel

Vision researchers receive grant from Research to Prevent Blindness

Jul 17 - The Medical College of Wisconsin received a grant of $110,000 from Research to Prevent Blindness (RPB) to support research into the causes, treatment, and prevention of blinding diseases. The research will be directed by Dale K. Heuer, MD, Chairman and Professor of Ophthalmology.

Congratulations to the Class of 2012

The 99th annual commencement took place on May 18 at the Milwaukee Theatre, at which the Medical College of Wisconsin and its Graduate School of Biomedical Sciences awarded 202 MD, 38 PhD, 27 MS, 4 MA, and 18 Master of Public Health degrees, as well as bestowed numerous honors.

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Page Updated 01/08/2014