MCW Research News – Basic Sciences

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Dr. Qizhen Shi receives Bayer Hemophilia Award

June 23 - Qizhen Shi, MD, PhD, associate professor of pediatrics (hematology/oncology), was one of 17 investigators from around the world to receive a grant as part of the Bayer Hemophilia Award Program (BHAP). Dr. Shi received the award during the International Society on Thrombosis and Haemostasis Congress in Toronto for his research on platelet gene therapy of Murine Hemophilia B with inhibitors.

Imagine More Dinner to raise funds for neuroscience research

May 13 - The third annual Imagine More Dinner to support neuroscience research at the Medical College of Wisconsin (MCW) Neuroscience Research Center will be held Sunday, June 28, at the Wisconsin Club, 900 W. Wisconsin Avenue in Milwaukee. Previously called the Park Dinner, the event has been renamed to reflect the spirit of hope and innovation.

Double teaming fight against childhood cancer

June 16 - Teamwork builds champions. Teamwork also helps save the lives of children with cancer. At least this is the case for a pair of MACC Fund Center researchers – one a scientist the other a clinician -- who make up an amicable and very likeable pair who have teamed up for the past five years to champion an initiative harnessing the power of one’s own natural immune system to fight childhood cancer.

The secrets of bone marrow: What leads to healthy blood cell production?

June 12 - The Medical College of Wisconsin (MCW) has received a five-year, $635,000 grant from the National Institutes of Health’s National Heart, Lung and Blood Institute to identify new potential treatments for diseases that inhibit the growth of blood cells and diseases in which the blood cells develop abnormally.

WBCS, Inc. to fund three breast cancer researchers

May 29 - Three researchers at the Medical College of Wisconsin (MCW) have each received a two-year, $100,000 grant from WBCS, Inc. (Wisconsin Breast Cancer Showhouse) to study cancer risks and potential new therapies.

AHA Awards MCW $3.7 Million for National Hypertension Research Center

May 27 - The American Heart Association (AHA) awarded MCW a four-year, $3.7 million grant to create a Strategically Focused Hypertension Research Center. MCW is one of four research centers nationwide that will form the AHA’s national hypertension network. Waukesha Now

Wound healing research part of MCW/VA collaboration

May 19 - The Medical College of Wisconsin and the Clement J. Zablocki VA Medical Center are collaborating to improve our understanding of small blood vessel function on wound healing. Veterans are at risk for chronic wounds that lead to amputation.

Dr. Flister Receives $1.75 Million NCI Grant to Study Factors that Impact Breast Cancer Risk

May 13 - Michael Flister, PhD, (Physiology) received a five-year, $1.75 million grant from the National Cancer Institute to identify factors in the microenvironment of tumors that impact breast cancer risk. The goal of this project is to develop a new genetic model to assess breast cancer risk in the tumor microenvironment. Milwaukee Journal Sentinel

Imaging the windows to the soul: eye researchers pursue “audacious” goal

May 1 - The Medical College of Wisconsin’s (MCW) Advanced Ocular Imaging Program (AOIP) has received a $4.4 million, five-year grant from the National Institutes of Health’s National Eye Institute (NEI) to participate in the NEI’s “Audacious Goals Initiative.” The initiative seeks to push the boundaries of vision science with the goal of regenerating neurons and neural connections in the eye.

A new use for older drugs to target the spread of breast cancer

Apr. 30 - The Medical College of Wisconsin (MCW) has received a five-year, $1.75 million grant from the National Institutes of Health’s National Cancer Institute to study a new approach at limiting the spread of breast cancer.

Dr. Bosnjak Receives $9 Million NIH Grant to Study Susceptibility of Diabetic Hearts to Injury

Apr. 28 - Zeljko Bosnjak, PhD, (Anesthesiology; Physiology) received a five-year, $9 million grant from the National Institute of General Medical Sciences to investigate the mechanisms responsible for the susceptibility of diabetic hearts to cardiac injury. Biz Times

MCW researcher to investigate diabetic heart susceptibility to cardiac injury

Apr. 21 - The Medical College of Wisconsin (MCW) has received a five-year, $9 million grant from the National Institutes of Health’s National Institute of General Medical Sciences to investigate the mechanisms responsible for the susceptibility of diabetic hearts to cardiac injury.

Researchers Partner on $8.5 Million NIH Grant to Wake Forest to Study Hormones

Apr. 20 - The Milwaukee Business Journal reports that MCW researchers will partner in an $8.5 million NIH grant to Wake Forest Baptist Medical Center. The five-year award, from the National Heart, Lung, and Blood Institute, will continue research on how hormones might contribute to heart disease and irregular heartbeats. Milwaukee Business Journal

American Heart Assoc. Names MCW as One of Four Centers for $15 Million Hypertension Study

Apr. 20 - MCW is one of four institutions selected to study hypertension as part of the American Heart Association’s four-year, $15 million Strategically Focused Research Network on Hypertension. The three other centers are University of Alabama at Birmingham, Cincinnati Children’s Hospital, and the University of Iowa. UAB News

Alumni/Students/Patients in Wisconsin

Wisconsin map of Alumni, Students and Patients

MCW receives federal funding to upgrade nuclear magnetic resonance facility for drug discovery

Mar. 12 - The Medical College of Wisconsin (MCW) has received a $600,000 grant from the National Institutes of Health’s Office of the Director to fund the purchase of a new robotic accessory to enhance MCW’s drug discovery efforts using nuclear magnetic resonance (NMR).

Dr. Kalyanaraman Receives $2.6 Million NIH Grant to Study Alcohol Liver Disease

Mar. 9 - Balaraman Kalyanaraman, PhD, (Biophysics) and collaborators at the University of Pennsylvania were jointly awarded a five-year, $2.6 million grant from the National Institute on Alcohol Abuse and Alcoholism to study the role of an enzyme in alcohol liver disease. Biz Times

Protein linked to development of asthma

Feb. 20 - Researchers at the Medical College of Wisconsin (MCW) have linked a specific protein to the development of post-viral infection asthma, which is the first step in generating a novel type of asthma therapy designed to prevent development of post-viral asthma in young children.

New genetically modified plants have better drought tolerance

Feb.11 - A team of researchers at the University of California, Riverside (UCR); and the Medical College of Wisconsin (MCW) has designed genetically-modified plants that can reduce water loss during times of drought, thus helping the plants survive.

Researcher to investigate causes of TB infection

Feb. 10 - The Medical College of Wisconsin (MCW) has received a two-year, $420,000 grant from the National Institutes of Health’s National Institute of Allergy and Infectious Diseases to study new therapeutic targets for tuberculosis.

Dr. Goldspink Creates Microstructures to Repair Damaged Heart Tissue

Feb. 9 - Paul Goldspink, PhD is lead author of an article published in Biomaterials that describes work by MCW scientists to create bioengineered structures that are the same size, shape and stiffness as heart muscle cells, work that may one day help doctors repair heart tissue and prevent heart failure. Milwaukee Journal Sentinel, Shiny Shiny and, Nanowerk

Vision scientists to explore causes of vision loss in albinism

Jan. 12 - The Medical College of Wisconsin (MCW) has received a four-year, $2 million grant from the National Institutes of Health’s National Eye Institute to study the specific parts of the visual system responsible for vision loss in albinism.

Lack of Sleep Can Cause Secretion of Molecule that Stokes Hunger

Jan. 6 - In a round-up article on sleep research studies nationwide, the Buffalo News reports on collaborative research by MCW and the University of Chicago that found that lack of sleep can cause the body to secrete a molecule called 2-AG, which stokes hunger. Buffalo News

Dr. Everson Discovers that Sleep Deprivation Causes Cellular Damage

Dec. 15 - Carol Everson, PhD is lead author of a study published in Sleep that found that sleep deprivation causes damage to cells, especially in the liver, lung, and small intestine. Medical News Today and Milwaukee Courier

MSTP Student Receives $180,000 NIH Grant to Study Development of Diabetes

Dec. 9 - Zach Shaheen, an MCW Medical Scientist Training Program (MSTP) student, received a four-year, $180,000 National Institute of Diabetes and Digestive and Kidney Diseases grant to investigate the pancreatic immune response involved in the development of insulin-dependent diabetes mellitus during a viral infection. MSTP students are enrolled in both MCW’s Medical School and Graduate School. Wauwatosa Now

MCW researchers find link between sleep deprivation and cell damage

Dec. 8 - Scientists at the Medical College of Wisconsin (MCW) have discovered a link between sleep loss and cell injury. Results of a new study find sleep deprivation causes the damage to cells, especially in the liver, lung, and small intestine. Recovery sleep following deprivation heals the damage.

NASA funds research into heart disease risks from space radiation

Dec. 5 - NASA has awarded John Baker, PhD, professor of cardiothoracic surgery and biochemistry at MCW, a five-year, $1.8 million grant to research the impact of cosmic radiation on astronauts’ cardiovascular health. Milwaukee Journal Sentinel

Opinion editorial: NIH needs funding to fight Ebola and other diseases

Nov. 20 - Dr. John R. Raymond, Sr., and Dr. Robert Golden, Dean of the UW School of Medicine & Public Health, co-authored an opinion editorial in the Wisconsin State Journal calling on Congress to approve funding for the National Institutes of Health for the new federal fiscal year that began on October 1. Wisconsin State Journal

Nature Reports on Dr. Brandow’s Research on Sickle Cell Disease Nerve Damage

Nov. 17 - Nature reports on Dr. Amanda Brandow’s research on sickle cell disease nerve damage. Nature

Congress Needs to Approve NIH Budget

Nov. 11 - Dr. John R. Raymond, Sr., and Dr. Robert Golden, Dean of the UW School of Medicine & Public Health, co-authored an opinion editorial in the Wisconsin State Journal calling on Congress to approve funding for the National Institutes of Health for the new federal fiscal year that began on October 1. Wisconsin State Journal

MCW scientist to investigate mediators of sickle cell disease pain

Nov. 11 - Katherine Zappia, a graduate student at the Medical College of Wisconsin has received a two-year, $85,000 fellowship from the Department of Health and Human Services’ National Institute of Neurological Disorders and Stroke to investigate the mediators contributing to the pain experienced in sickle cell disease.

Researcher to investigate Leptospira

Nov. 6 - Jenifer Coburn, PhD has been awarded an NIH grant to study the mechanisms of leptospira bacteria. Wauwatosa Now

MCW researcher to investigate leptospira bacteria

Oct. 27 - The Medical College of Wisconsin has received a two-year, $420,000 grant from the National Institutes of Health’s National Institute of Allergy and Infectious Diseases to advance the understanding of leptospirosis, a serious bacterial infection affecting humans and animals, and how it establishes persistent infection in the kidney.

Dr. Klug Receives $1.2 Million NIH Grant to Advance Understanding of Endotoxin

Oct.14 - Candice Klug, PhD received a four-year, $1.2 million grant from the National Institute of General Medical Sciences to advance the understanding of how endotoxin, a major component of disease-causing bacteria, is transported within the cell. Wauwatosa Now

Center for Imaging Research seeks grant applications

Oct. 2 - The Center for Imaging Research seeks grant applications to provide vital funding for innovative imaging-based research projects at the 3T and 7T scanners. The Center will issue five $5,000 and five $15,000 awards to be used for MRI scanner fees and applicable subject stipends and transportation costs.

Can you prevent diabetes?

Oct. 10 - A collaborative team of researchers from the Medical College of Wisconsin (MCW) and the Milwaukee School of Engineering has received a one-year, $50,000 grant from the Clinical and Translational Science Institute of Southeast Wisconsin (CTSI) to study possible interventions to prevent the development of type 1 diabetes (T1D).

Drug mitigates early Parkinson’s symptoms in mouse model

Oct. 9 - A team of researchers has shown that long-term administration of a novel drug to mice exhibiting Parkinson’s disease-like symptoms is effective in mitigating loss of smell, improving motor coordination and preventing the tendency to fall – all early symptoms of Parkinson’s disease. A manuscript highlighting these findings has been accepted for publication in the journal, Neuroscience Letters.

MCW researcher receives funding from new “Big Data to Knowledge” initiative

Oct. 9 - The Medical College of Wisconsin (MCW) has received a five-year, $500,000 training grant from the National Institutes of Health’s (NIH) National Institute of Environmental Health Sciences to investigate the development of a tool to interpret the genetic data of humans affected with cardiovascular disease.

Dr. Coburn Receives $1.5 Million NIH Grant to Advance Understanding of Leptospirosis

Jenifer Coburn, PhD received a four-year, $1.5 million grant from the National Institute of Allergy and Infectious Diseases to advance the understanding of leptospirosis, a serious bacterial infection affecting humans and animals worldwide. Wauwatosa Now

MCW Researcher to Investigate Bacterial Endotoxin

Oct. 7 - The Medical College of Wisconsin (MCW) has received a four-year, $1.2 million grant from the National Institutes of Health’s National Institute of General Medical Sciences to advance the understanding of how endotoxin, a major component of disease-causing bacteria, is transported within the cell.

MCW researcher to investigate the bacterial-host interactions in leptospirosis

Oct. 2 - The Medical College of Wisconsin has received a four-year, $1.5 million grant from the National Institutes of Health’s National Institute of Allergy and Infectious Diseases to advance the understanding of leptospirosis, a serious bacterial infection affecting humans and animals worldwide.

Dr. Beyer Receives Office of the NIH Director Grant to Study Novel Disease Models

Oct. 1 - Andreas Beyer, PhD is principal investigator of a two-year, $470,000 grant from the Office of the Director of the NIH to generate and characterize novel disease models of use for the greater scientific community. Wauwatosa Now

Drs. Sengupta and Banerjee Receive $1.8 Million NIH Grant to Study Chronic Pelvic Pain

Sept. 30 - Jyoti Sengupta, PhD, and Banani Banerjee, PhD, (both Medicine – Gastroenterology and Hepatology) will serve as the primary investigators of a four-year, $1.8 million National Diabetes and Digestive and Kidney Diseases grant to study the genetic and physical causes of chronic pelvic pain. Becker's ASC Review and Biz Times

Scientist receives NIH Director’s Award to study molecular causes of disease

Sept. 23 - The Medical College of Wisconsin has received a two-year, $470,000 exploratory grant from the Office of the Director of the National Institutes of Health to generate and characterize novel disease models of use for the greater scientific community.

Dr. Woods Identifies New Gene Associated with Traits Involved in Diabetes

Sept. 22 - In a study published in Genetics, Leah Solberg Woods, PhD and colleagues reported that they had has identified a new gene associated with fasting glucose and insulin levels in rats, mice and in humans; traits involved in diabetes. Nature World News, Health Canal, Medical Xpress and Bio-Medicine

Drs. Volkman and Grayson Receive NIH Grant to Identify New Therapeutic Targets for COPD

Sept. 15 - Brian Volkman, PhD and Dr. Mitchell Grayson are co-primary investigators of a one-year, $382,500 grant from the National Institute of Allergy and Infectious Diseases to identify new therapeutic targets for chronic obstructive lung diseases such as asthma and chronic obstructive pulmonary disease. Biz Times

MCW resident awarded NIH loan repayment grant

Sept. 05 - Mohamed Algahim, MD, a resident in the integrated cardiothoracic surgery program at MCW, has been awarded a loan repayment grant from the National Institutes of Health (NIH).

MCW scientists to investigate new therapy for obstructive lung disease

Sept. 04 - The Medical College of Wisconsin has received a one year, $382,500 grant from the National Institutes of Health’s National Institute of Allergy and Infectious Diseases to identify new therapeutic targets for chronic obstructive lung diseases such as asthma and chronic obstructive pulmonary disease.

The Role of MicroRNA’s in High Blood Pressure

Aug. 26 - The Medical College of Wisconsin has received a four year, $1.5 million grant from the National Institutes of Health’s National Heart, Lung and Blood Institute to study the role of a specific microRNA in the development of hypertension and associated kidney injury.

Dr. Sorokin Receives NCI Grant to Evaluate New Pathway for Inhibiting Cancer Cell Growth

Aug. 04 - Andrey Sorokin. PhD received a two-year, $153,000 grant from the National Cancer Institute to evaluate COX-2 regulation as a potential new pathway for inhibiting the growth of cancer cells. Wauwatosa Now

$2.6 Million NIH Grant Awarded to Study New Treatment Approaches for Pancreatic Cancer

Michael Dwinell, PhD and Balaraman Kalyanaraman, PhD received a five-year, $2.6 million grant from the National Cancer Institute to study new therapeutic approaches to treat pancreatic cancer. Wauwatosa Now

Researchers to explore new treatments for pancreatic cancer

The Medical College of Wisconsin has received a five-year, $2.6 million grant from the National Institutes of Health’s National Cancer Institute to study new therapeutic approaches to treat pancreatic cancer.

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