Appraisal of MEG/EEG source models

Throughout these pages, we have been dealing with modeling, and modeling implies dealing with uncertainty. MEG/EEG source estimation has uncertainty everywhere: data are complex and contaminated with various nuisances, source models are simplistic, head models have approximated geometries and conductivity properties, the choice of priors has its share of subjectivity, etc.

It is therefore reasonable to question how sensitive the numerical methods at stake are to these possible sources of errors and bias. This concerns the appraisal of the source model, which general methodology has been adapted to MEG/EEG just recently and is now achieving significant maturity.

(1) Confidence intervals

It is important to evaluate the confidence one might acknowledge to a given model. In other words, we are now looking for error bars that would define a confidence interval about the estimated values of a source model.


(2) Statistical inference

Questions like: ‘How different is the dipole location between these two experimental conditions? ’ and ‘Are source amplitudes larger in such condition that in a control condition? ’ belong to statistical inference from experimental data.


Froedtert & The Medical College of Wisconsin MEG Contact Information

Research investigators and clinical physicians are encouraged to contact us for further information on how to access our MEG Program and services.

  • Jeffrey Stout, PhD: Technical Manager
  • Jean Roccapalumba, CTRS, MBA: Program Manager

Mailing Address:

MEG Program
Department of Neurology
Medical College of Wisconsin
9200 W. Wisconsin Ave.
Milwaukee, WI 53226

MEG Program Site Map

If you are a physician and would like to inquire about or order a MEG study for your patients, please visit Froedtert Hospital MEG web pages for basic information about the procedure and/or contact Linda Allen, RN BSN, our Epilepsy Program Coordinator at (414) 805-3641 to refer your patient to our Program.

If you are a patient who is about to undergo an MEG procedure, please also visit Froedtert Hospital MEG web pages for useful information regarding the MEG routine.

Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53226
(414) 955-8296
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Page Updated 11/02/2015