Basic EEG sensing technology is extremely mature and relatively cost-effective, thanks to its wide distribution in the clinical world. The basic principles of EEG consist of the measurement of differences in electrical potentials between couples of electrodes. Two typical set-ups are available:
- Bipolar electrode montages, where electrodes are arranged in pairs. Hence electrical potential differences are measured relatively within each electrode pairs;
- Monopolar electrode montages, where voltage differences are measured relatively to a unique reference electrode.
Electrodes may be manufactured using multiple possible materials: Silver/silver chloride compounds are the most common and excel in most aspects of the required specifications: low impedance (from 1 to 20 KΩ) and relatively wide frequency responses (from direct currents to ideally the KHz range). The contact with the skin is critical to signal quality. Skin preparation is essential and the time required is commensurate to the number of electrodes used in the montage. The skin needs to be lightly abraded and cleansed before a special conductive medium – a paste, generally – is applied between the skin and the electrode.
Advanced EEG solutions are constantly being proposed to research investigators and include essentially:
- A greater number of sensors (up to 256, typically; see Fig. 4);
- Faster sampling rates (~5KHz on all channels);
- Facilitated electrode positioning and preparation (with spongy electrolyte contacts or active ‘dry’ electrodes); and
- Multimodal compatibility (whereby EEG can be recorded concurrently to MEG or fMRI).
In that respect, EEG remains one of the very few brain sensing technologies that are capable of bridging multiple environments: from very high to ultra-low magnetic fields, and may also be used in ambulatory mode. The ideal EEG laboratory however requires that recordings take place in a room with walls containing conducting materials, as a Faraday cage, for the reduction of electrostatic interferences.
Though electrodes may be glued to the subject’s skin, more practical solutions exist for short-term subject monitoring: electrodes are inserted into elastic caps or nets that can be adapted to the subject’s head in a reasonable amount of time. Subject preparation is indeed a factor of importance when using EEG. Electrode application to position digitization – an optional step if source imaging is not required by the experiment – require about 30 minutes from well-trained operators. Conductivity bridges, impedance drifts – due to degradation of the contact gel – and relative subject discomfort (when using caps on hour-long recordings) are also important factors to consider when designing an EEG experiment. Most advanced EEG systems integrate tools for the online verification of electrode impedances. Typical amplitudes of ongoing EEG signals range between 0.1 to 5 μV.
Froedtert & The Medical College of Wisconsin MEG Contact Information
Research investigators and clinical physicians are encouraged to contact us for further information on how to access our MEG Program and services.
Jeffrey Stout, PhD: Technical Manager
Send an email | (414) 805-1174 | (414) 805-1103 (fax)
Jean Roccapalumba, CTRS, MBA: Program Manager
Send an email | (414) 805-9906 | (414) 259-1159 (fax)
Department of Neurology
Medical College of Wisconsin
9200 W. Wisconsin Avenue
Milwaukee, WI 53226
MEG Program Site Map
If you are a physician and would like to inquire about or order a MEG study for your patients, please visit Froedtert Hospital MEG web pages for basic information about the procedure and/or contact Linda Allen, RN BSN, our Epilepsy Program Coordinator at (414) 805-3641 to refer your patient to our Program.
If you are a patient who is about to undergo an MEG procedure, please also visit Froedtert Hospital MEG web pages for useful information regarding the MEG routine.