2014 - 2015


Book Chapters

  • Driver, J.P., Serreze, D.V., Y.-G. Chen. Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease. Semin Immunopathol. 2011; 33:67-87.

  • Heneghan M, Alemzadeh R. Cushing disease as possible cause of persistent growth failure despite growth hormone therapy in a small for gestational age male. Pituitary. 2009 Sep 22. PMID: 19771523.
  • Alemzadeh R, Parton EA, Holzum MK. Feasibility of continuous subcutaneous insulin infusion and daily supplemental insulin glargine injection in children with type 1 diabetes. Diabetes Technol Ther. 2009 Aug;11(8):481-6. PMID: 19698060.
  • Chen F, Zhang G, Cao Y, Hessner MJ, See WA. MB49 murine urothelial carcinoma: molecular and phenotypic comparison to human cell lines as a model of the direct tumor response to bacillus Calmette-Guerin. J Urol. 2009 Dec;182(6):2932-7. PMID: 19853870.
  • Jana S, Jailwala P, Haribhai D, Waukau J, Glisic S, Grossman W, Mishra M, Wen R, Wang D, Williams CB, Ghosh S. The role of NF-kappaB and Smad3 in TGF-beta-mediated Foxp3 expression. Eur J Immunol. 2009 Sep;39(9):2571-83. PMID: 19701891.
  • Jailwala P, Waukau J, Glisic S, Jana S, Ehlenbach S, Hessner M, Alemzadeh R, Matsuyama S, Laud P, Wang X, Ghosh S. Apoptosis ofCD4+CD25(high) T cells in type 1 diabetes may be partially mediated by IL-2 deprivation. PLoS One. 2009 Aug 5;4(8):e6527.PMID: 19654878
  • Glisic S, Klinker M, Waukau J, Jailwala P, Jana S, Basken J, Wang T, Alemzadeh R, Hagopian W, Ghosh S. Genetic association of HLA DQB1 with CD4+CD25+(high) T-cell apoptosis in type 1 diabetes. Genes Immun. 2009 Jun;10(4):334-40. PMID: 19295543.
  • Chen X, Das R, Komorowski R, Beres A, Hessner MJ, Mihara M, Drobyski WR. Blockade of interleukin-6 signaling augments regulatory T-cell reconstitution and attenuates the severity of graft-versus-host disease. Blood. 2009 Jul 23;114(4):891-900. PMID: 19491393
  • Reddy S, Jia S, Geoffrey R, Lorier R, Suchi M, Broeckel U, Hessner MJ, Verbsky J. An autoinflammatory disease due to homozygous deletion of the IL1RN locus. N Engl J Med. 2009 Jun 4;360(23):2438-44. PubMed PMID: 19494219
  • Babar GS, Ali O, Parton EA, Hoffmann RG, Alemzadeh R. Factors associated with adherence to continuous subcutaneous insulin infusion in pediatric diabetes. Diabetes Technol Ther. 2009 Mar;11(3):131-7. PMID: 19216689.
  • Wang T, Jacob H, Ghosh S, Wang X, Zeng ZB. A joint association test for multiple SNPs in genetic case-control studies. Genet Epidemiol. 2009Feb;33(2):151-63.PMID: 18770519
  • Evertsen J, Alemzadeh R, Wang X. Increasing incidence of pediatric type 1 diabetes mellitus in Southeastern Wisconsin: relationship with body weight at diagnosis. PLoS One. 2009 Sep 3;4(9):e6873.PMID: 19727402
  • Hains AA, Berlin KS, Davies WH, Sato AF, Smothers MK, Clifford LC, Alemzadeh R. Attributions of teacher reactions to diabetes self-care behaviors. J Pediatr Psychol. 2009 Jan-Feb;34(1):97-107. PMID: 18445646.
  • Schulteis RD, Chu H, Dai X, Chen Y, Edwards B, Haribhai D, Williams CB, Malarkannan S, Hessner MJ, Glisic-Milosavljevic S, Jana S, Kerschen EJ, Ghosh S, Wang D, Kwitek AE, Lernmark A, Gorski J, Weiler H. Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking Gimap5. Blood. 2008 Dec 15;112(13):4905-14. PMID: 18796632
  • Alemzadeh R, Karlstad MD, Tushaus K, Buchholz M. Diazoxide enhances basal metabolic rate and fat oxidation in obese Zucker rats. Metabolism. 2008 Nov;57(11):1597-607.PMID: 18940400.
  • Heiden TC, Struble CA, Rise ML, Hessner MJ, Hutz RJ, Carvan MJ 3rd. Molecular targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) within the zebrafish ovary: insights into TCDD-induced endocrine disruption and reproductive toxicity. Reprod Toxicol. 2008 Jan;25(1):47-57. PMID: 17884332
  • Nittala A, Wang X. The hyperbolic effect of density and strength of inter beta-cell coupling on islet bursting: a theoretical investigation. Theor Biol Med Model. 2008 Aug 3;5:17. PubMed PMID: 18673579
  • Zidan H, Lo S, Wiebe D, Talano J, Alemzadeh R. Severe hypercholesterolemia mediated by lipoprotein X in a pediatric patient with chronic graft-versus-host disease of the liver. Pediatr Blood Cancer. 2008 Jun;50(6):1280-1. PMID: 18286546.
  • Das R, Chen X, Komorowski R, Hessner MJ, Drobyski WR. Interleukin-23 secretion by donor antigen-presenting cells is critical for organ-specific pathology in graft-versus-host disease. Blood. 2009 Mar 5;113(10):2352-62. PMID: 19059877
  • Wang X, Jia S, Geoffrey R, Alemzadeh R, Ghosh S, Hessner MJ. Identification of a molecular signature in human type 1 diabetes mellitus using serum and functional genomics. J Immunol. 2008 Feb 1;180(3):1929-37. PMID: 18209091.
  • Alemzadeh R, Kichler J, Babar G, Calhoun M. Hypovitaminosis D in obese children and adolescents: relationship with adiposity, insulin sensitivity, ethnicity, and season. Metabolism. 2008 Feb;57(2):183-91. PMID: 18191047.
  • Gao S, Wang X. TAPPA: topological analysis of pathway phenotype association. Bioinformatics. 2007 Nov 15;23(22):3100-2. PMID: 17890270
  • Nittala A, Ghosh S, Wang X. Investigating the role of islet cytoarchitecture in its oscillation using a new beta-cell cluster model. PLoS One. 2007 Oct 3;2(10):e983. PubMed PMID: 17912360
  • Glisic-Milosavljevic S, Wang T, Koppen M, Kramer J, Ehlenbach S, Waukau J, Jailwala P, Jana S, Alemzadeh R, Ghosh S. Dynamic changes in CD4+ CD25+(high) T cell apoptosis after the diagnosis of type 1 diabetes. Clin Exp Immunol. 2007 Oct;150(1):75-82. PMID: 17711492
  • Wang X, Jia S, Meyer L, Yassai MB, Naumov YN, Gorski J, Hessner MJ. Quantitative measurement of pathogen-specific human memory T cell repertoire diversity using a CDR3 beta-specific microarray. BMC Genomics. 2007 Sep 19;8:329. PMID: 17880719
  • Alemzadeh R, Palma Sisto P, Holzum M, Parton E, Kicher J. Continuous subcutaneous insulin infusion attenuated glycemic instability in preschool children with type 1 diabetes mellitus. Diabetes Technol Ther. 2007 Aug;9(4):339-47. PMID: 17705689.
  • Hains AA, Berlin KS, Davies WH, Smothers MK, Sato AF, Alemzadeh R. Attributions of adolescents with type 1 diabetes related to performing diabetes care around friends and peers: the moderating role of friend support. J Pediatr Psychol. 2007 Jun;32(5):561-70. PMID: 17090550.
  • Glisic-Milosavljevic S, Waukau J, Jailwala P, Jana S, Khoo HJ, Albertz H, Woodliff J, Koppen M, Alemzadeh R, Hagopian W, Ghosh S. At-risk and recent-onset type 1 diabetic subjects have increased apoptosis in the CD4+CD25+ T-cell fraction. PLoS One. 2007 Jan 3;2(1):e146. PMID: 17206281
  • Geoffrey R, Jia S, Kwitek AE, Woodliff J, Ghosh S, Lernmark A, Wang X, Hessner MJ. Evidence of a functional role for mast cells in the development of type 1 diabetes mellitus in the BioBreeding rat. J Immunol. 2006 Nov 15;177(10):7275-86. PMID: 17082646.
  • Nolan K, Schiller J, Ghosh S, Magnuson V. Identification of a novel HLA-DQB1 allele, DQB1*060403, by sequence-based typing. Tissue Antigens. 2006 Nov;68(5):456-7. PMID: 17092265.
  • Guo SW, Magnuson VL, Schiller JJ, Wang X, Wu Y, Ghosh S. Meta-analysis of vitamin D receptor polymorphisms and type 1 diabetes: a HuGE review of genetic association studies. Am J Epidemiol. 2006 Oct 15;164(8):711-24. PMID: 16905645.
  • Alemzadeh R, Ellis J, Calhoun M, Kichler J. Predictors of metabolic control at one year in a population of pediatric patients with type 2 diabetes mellitus: a retrospective study. J Pediatr Endocrinol Metab. 2006 Sep;19(9):1141-9. PMID: 17128562.
  • Wang X, He Z, Ghosh S. Investigation of the age-at-onset heterogeneity in type 1 diabetes through mathematical modeling. Math Biosci. 2006 Sep;203(1):79-99. PMID: 16723139.
  • Wang X, Jia S, Meyer L, Xiang B, Chen LY, Jiang N, Moreno C, Jacob HJ, Ghosh S, Hessner MJ. Comprehensive quality control utilizing the prehybridization third-dye image leads to accurate gene expression measurements by cDNA microarrays. BMC Bioinformatics. 2006 Aug 14;7:378. PMID: 16907976
  • Nittala A, Ghosh S, Stefanovski D, Bergman R, Wang X. Dimensional analysis of MINMOD leads to definition of the disposition index of glucose regulation and improved simulation algorithm. Biomed Eng Online. 2006 Jul 14;5:44. PMID: 16842624
  • Hains AA, Berlin KS, Davies WH, Parton EA, Alemzadeh R. Attributions of adolescents with type 1 diabetes in social situations: relationship with expected adherence, diabetes stress, and metabolic control. Diabetes Care. 2006 Apr;29(4):818-22. PMID: 16567821.
  • Hessner MJ, Xiang B, Jia S, Geoffrey R, Holmes S, Meyer L, Muheisen S, Wang X. Three-color cDNA microarrays with prehybridization quality control yield gene expression data comparable to that of commercial platforms. Physiol Genomics. 2006 Mar 13;25(1):166-78. PMID: 16403843.
  • Hessner MJ, Liang M, Kwitek AE. The application of microarray analysis to pediatric diseases. Pediatr Clin North Am. 2006 Aug;53(4):579-90. Review. PMID: 16872994.
  • Wu Y, Kajdacsy-Balla A, Strawn E, Basir Z, Halverson G, Jailwala P, Wang Y, Wang X, Ghosh S, Guo SW. Transcriptional characterizations of differences between eutopic and ectopic endometrium. Endocrinology. 2006 Jan;147(1):232-46. PMID: 16195411
  • Alemzadeh R, Tushaus K. Diazoxide attenuates insulin secretion and hepatic lipogenesis in zucker diabetic fatty rats. Med Sci Monit. 2005 Dec;11(12):BR439-48. PMID: 16319780.
  • Glisic-Milosavljevic S, Waukau J, Jana S, Jailwala P, Rovensky J, Ghosh S. Comparison of apoptosis and mortality measurements in peripheral blood mononuclear cells (PBMCs) using multiple methods. Cell Prolif. 2005 Oct;38(5):301-11. PMID: 16202038.
  • Liang M, Cowley AW Jr, Hessner MJ, Lazar J, Basile DP, Pietrusz JL. Transcriptome analysis and kidney research: toward systems biology. Kidney Int. 2005 Jun;67(6):2114-22. Review. PMID: 15882254.
  • Alemzadeh R, Palma Sisto P, Parton EA, Holzum MK. Continuous subcutaneous insulin infusion and multiple dose of insulin regimen display similar patterns of blood glucose excursions in pediatric type 1 diabetes. Diabetes Technol Ther. 2005 Aug;7(4):587-96. PMID: 16120030.
  • Alemzadeh R, Berhe T, Wyatt DT. Flexible insulin therapy with glargine insulin improved glycemic control and reduced severe hypoglycemia among preschool-aged children with type 1 diabetes mellitus. Pediatrics. 2005 May;115(5):1320-4. PMID: 15867042.
  • Hessner MJ, Wang X, Meyer L, Geoffrey R, Jia S, Fuller J, Lernmark A, Ghosh S. Involvement of eotaxin, eosinophils, and pancreatic predisposition in development of type 1 diabetes mellitus in the BioBreeding rat. J Immunol. 2004 Dec 1;173(11):6993-7002. PMID: 15557196.
  • Alemzadeh R, Tushaus KM. Modulation of adipoinsular axis in prediabetic zucker diabetic fatty rats by diazoxide. Endocrinology. 2004 Dec;145(12):5476-84. PMID: 15319354.
  • Hessner MJ, Meyer L, Tackes J, Muheisen S, Wang X. Immobilized probe and glass surface chemistry as variables in microarray fabrication. BMC Genomics. 2004 Aug 4;5(1):53. PMID: 15294027
  • Pati N, Schowinsky V, Kokanovic O, Magnuson V, Ghosh S. A comparison between SNaPshot, pyrosequencing, and biplex invader SNP genotyping methods: accuracy, cost, and throughput. J Biochem Biophys Methods. 2004 Jul 30;60(1):1-12. PMID: 15236905.
  • Alemzadeh R, Ellis JN, Holzum MK, Parton EA, Wyatt DT. Beneficial effects of continuous subcutaneous insulin infusion and flexible multiple daily insulin regimen using insulin glargine in type 1 diabetes. Pediatrics. 2004 Jul;114(1):e91-5. PMID: 15231979.
  • Hessner MJ, Singh VK, Wang X, Khan S, Tschannen MR, Zahrt TC. Utilization of a labeled tracking oligonucleotide for visualization and quality control of spotted 70-mer arrays. BMC Genomics. 2004 Feb 9;5(1):12. PMID: 15018646
  • Yang J, Wong RK, Wang X, Moibi J, Hessner MJ, Greene S, Wu J, Sukumvanich S, Wolf BA, Gao Z. Leucine culture reveals that ATP synthase functions as a fuel sensor in pancreatic beta-cells. J Biol Chem. 2004 Dec 24;279(52):53915-23. PMID: 15489222.
  • Schlicht M, Matysiak B, Brodzeller T, Wen X, Liu H, Zhou G, Dhir R, Hessner MJ, Tonellato P, Suckow M, Pollard M, Datta MW. Cross-species global and subset gene expression profiling identifies genes involved in prostate cancer response to selenium. BMC Genomics. 2004 Aug 20;5(1):58. PMID: 15318950
  • Morrison J, Knoll K, Hessner MJ, Liang M. Effect of high glucose on gene expression in messangial cells: upregulation of the thiol pathway is an adaptational response. Physiol Genomics. 2004 May 19;17(3):271-82. PMID: 15039483.
  • Patnaik M, Dlott JS, Fontaine RN, Subbiah MT, Hessner MJ, Joyner KA, Ledford MR, Lau EC, Moehlenkamp C, Amos J, Zhang B, Williams TM. Detection of genomic polymorphisms associated with venous thrombosis using the invader biplex assay. J Mol Diagn. 2004 May;6(2):137-44. PMID: 15096570
  • Alemzadeh R, Fledelius C, Bodvarsdottir T, Sturis J. Attenuation of hyperinsulinemia by NN414, a SUR1/Kir6.2 selective K-adenosine triphosphate channel opener, improves glucose tolerance and lipid profile in obese Zucker rats. Metabolism. 2004 Apr;53(4):441-7. PMID: 15045689.
  • Zhou G, Wen X, Liu H, Schlicht MJ, Hessner MJ, Tonellato PJ, Datta MW. B.E.A.R. GeneInfo: a tool for identifying gene-related biomedical publications through user modifiable queries. BMC Bioinformatics. 2004 Apr 29;5:46. PMID: 15117422
  • Alemzadeh R, Zhang J, Tushaus K, Koontz J. Diazoxide enhances adipose tissue protein kinase B activation and glucose transporter-4 expression in obese Zucker rats. Med Sci Monit. 2004 Mar;10(3):BR53-60. PMID: 14976464.
  • Browning MB, Woodliff JE, Konkol MC, Pati NT, Ghosh S, Truitt RL, Johnson BD. The T cell activation marker CD150 can be used to identify alloantigen-activated CD4(+)25+ regulatory T cells Cell Immunol. 2004 Feb;227(2):129-39.PMID: 15135295

Book Chapters

  • Wang, X., and M.J. Hessner. Quantitative quality control of microarray experiments: toward accurate gene expression measurements. 2005. In Cambridge University Press: Gene Expression Profiling by Microarrays - Clinical Implications. Wolf-Karsten Hofmann (editor). (In Press).
  • Hessner M, Wang X, Ghosh S. Genetics of type 1 diabetes. Diabetes Mellitus: A fundamental and clinical text. (eds. LeRoith D, Taylor S.I., Olefsky J.M.: Lippincott Williams & Wilkins Publishers), pp. 483-498, 2004.
  • Broeckel, U. and M.J. Hessner. 2004. Single Nucleotide Polymorphisms: Testing DNA Variation for Disease Association In: Humana Press, Molecular Diagnostics for the Clinical Laboratorian. W.B. Coleman and G.J. Tsongalis (editors).
  • Waukau J, Jailwala P, Wang Y, Khoo HJ, Ghosh S, Wang X, Hessner MJ. The design of a gene chip for functional immunological studies on a high-quality control platform. Ann N Y Acad Sci. 2003 Nov;1005:284-7. PMID: 14679077.
  • Pati N, Ghosh S, Hessner MJ, Khoo HJ, Wang X. Difference in gene expression profiles between human CD4+CD25+ and CD4+CD25- T cells. Ann N Y Acad Sci. 2003 Nov;1005:279-83. PMID: 14679076.
  • Alemzadeh R, Palma Sisto P, Parton E, Totka J, Kirby M. Beneficial effects of flexible insulin therapy in children and adolescents with type 1 diabetes mellitus. Acta Diabetol. 2003 Sep;40(3):137-42.PMID: 14605970.
  • Wang X, Hessner MJ, Wu Y, Pati N, Ghosh S. Quantitative quality control in microarray experiments and the application in data filtering, normalization and false positive rate prediction. Bioinformatics. 2003 Jul 22;19(11):1341-7. PMID: 12874045.
  • Hessner MJ, Wang X, Khan S, Meyer L, Schlicht M, Tackes J, Datta MW, Jacob HJ, Ghosh S. Use of a three-color cDNA microarray platform to measure and control support-bound probe for improved data quality and reproducibility. Nucleic Acids Res. 2003 Jun 1;31(11):e60. PMID: 12771224
  • Alemzadeh R, Loppnow C, Parton E, Kirby M. Glucose sensor evaluation of glycemic instability in pediatric type 1 diabetes mellitus. Diabetes Technol Ther. 2003;5(2):167-73. PMID: 12871606.
  • Hessner MJ, Wang X, Hulse K, Meyer L, Wu Y, Nye S, Guo SW, Ghosh S. Three color cDNA microarrays: quantitative assessment through the use of fluorescein-labeled probes. Nucleic Acids Res. 2003 Feb 15;31(4):e14. PubMed PMID: 12582259
  • Wang X, Jiang N, Feng X, Xie Y, Tonellato PJ, Ghosh S, Hessner MJ. A novel approach for high-quality microarray processing using third-dye array visualization technology. IEEE Trans NanoBioscience. 2003 Dec;2(4):193-201. PMID: 15376909.
  • Raife TJ, Lentz SR, Atkinson BS, Vesely SK, Hessner MJ. Factor V Leiden: a genetic risk factor for thrombotic microangiopathy in patients with normal von Willebrand factor-cleaving protease activity. Blood. 2002 Jan 15;99(2):437-42. PMID: 11781222.
  • Ekman GC, Billingsly R, Hessner MJ. Rh genotyping: avoiding false-negative and false-positive results among individuals of African ancestry. Am J Hematol. 2002 Jan;69(1):34-40. PMID: 11835329.
  • Wang Y, Wang X, Guo SW, Ghosh S. Conditions to ensure competitive hybridization in two-color microarray: a theoretical and experimental analysis. Biotechniques. 2002 Jun;32(6):1342-6.PMID: 12074165
  • Wang X, Ghosh S, Guo SW. Quantitative quality control in microarray image processing and data acquisition. Nucleic Acids Res. 2001 Aug 1;29(15):E75-5. PMID: 11470890
  • Binion DG, Alemzadeh R. Growth of an IBD controversy: growth hormone and Crohn's disease. Inflamm Bowel Dis. 2001 May;7(2):176-8. PMID: 11383593.
  • Guo SW. Does higher concordance in monozygotic twins than in dizygotic twins suggest a genetic component? Hum Hered. 2001;51(3):121-32. PMID: 11173963.
  • Guo SW, Lange K. Genetic mapping of complex traits: promises, problems, and prospects. Theor Popul Biol. 2000 Feb;57(1):1-11. Review. PMID: 10708625.

Book Chapters

  • Ghosh S. Positional cloning strategies to identify causal genes for type 2 diabetes mellitus. In Diabetes Mellitus: A fundamental and clinical text, (eds. LeRoith D. Taylor S.I., Olefsky J.: Lippincott-Raven Publishers). pp 664-674, 2000.
  • Nye S, Ghosh S. Genetics of complex diseases. Genetics of Diabetes Mellitus, pp 1-25. Editor William L. Lowe, Jr, MD. Kluwer Academic Publishers. 2001.

Contact Us

The Max McGee National Research Center for Juvenile Diabetes
8701 Watertown Plank Rd.
Milwaukee, WI 53226

(414) 955-7351
(414) 955-6663 (fax)

Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53226
(414) 955-8296
Directions & Maps
© 2015

Page Updated 11/02/2015