Andrew KleistAndrew Kleist

akleist@mcw.edu

Research Interests

Structural biology and drug discovery, G protein-coupled receptor (GPCR) structure, signaling, and biased agonism at GPCRs, Chemokine and chemokine receptor biology as it relates to cancer pathogenesis

Advisor: Brian Volkman, PhD, Department of Biochemistry
Research page

Education

BS, 2011, Duke University
Major: Biology

Research Experience

Duke University, 2010-2011
Advisor: Robert Lefkowitz, MD
Project: Helped develop a radioligand binding assay to characterize the extent to which ligands modulate the Angiotensin 1a receptor to recruit intracellular G protein and beta-arrestin effectors.

Duke University, 2011-2012
Advisor: Robert Lefkowitz, MD
Project: Participated in high throughput screening efforts to identify compounds that exclusively activate the beta-2-adrenergic receptor through the intracellular effector beta-arrestin.

Publications

Weiss DR, Ahn S, Sassano MF, Kleist A, Zhu X, Strachan R, Roth BL, Lefkowitz RJ, Shoichet BK. Conformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptor. ACS Chem Biol. 2013 May 17;8(5):1018-26.

Strachan RT, Sun JP, Rominger DH, Violin JD, Ahn S, Rojas Bie Thomsen A, Zhu X, Kleist A, Costa T, Lefkowitz RJ. Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR). J Biol Chem. 2014 May 16;289(20):14211-24.

Meeting Abstracts

Kleist, A., R. Tyler, F.C. Peterson, T.M. Handel, and B.F. Volkman. 2015. Surveying conformational landscapes at chemokine receptors using Nuclear Magnetic Resonance spectroscopy. Abstract for poster presentation. Membrane Protein Structures Meeting, Argonne National Laboratory, Lemont, Illinois, April 2015.

Interests

ice hockey, reading, NPR

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