Brennan Decker

bdecker@mcw.edu

Research Interest

I'm interested in all aspects of applying genome sequencing technologies to improve medical care, including approaches to diagnosis, prognosis, treatment selection, and recurrence detection.

Education

BA, 2005, St. Olaf College
Majors: Biology and Chemistry

Research Experience

University of Cambridge, School of Medicine, Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, 2012-2016
Advisor: Prof. Douglas F. Easton
Project: Led population-scale targeted resequencing and analysis for 65 breast cancer risk genes. Demonstrated that only a subset of putative risk genes have clear evidence for use in genetic counseling.

National Institutes of Health, National Human Genome Research Institute, Cancer Genetics and Comparative Genomics Branch, 2011-2016
Advisor: Dr. Elaine A. Ostrander
Project: Used whole genome sequencing to identify a distinct molecular subtype of aggressive prostate tumors, which may have utility as a prognostic and treatment selection biomarker.

Publications

Decker B, Karyadi DM, Davis BW, Karlins E, Tillmans LS, Stanford JL, Thibodeau SN, Ostrander EA. (2016). Biallelic BRCA2 mutations shape the somatic mutational landscape of aggressive prostate tumors. The American Journal of Human Genetics 98(5):818-829.

Easton DF, Lesueur F, Decker B, Michailidou K, Li J, Allen J, Luccarini C, Pooley KA, Shah M, Bolla MK, Wang Q, Dennis J, Ahmad J, Thompson ER, Damiola F, Pertesi M, Voegele C, Mebirouk N, Robinot N, Durand G, Forey N, Luben RN, Ahmed S, Aittomäki K, Anton-Culver H, Arndt V, Australian Ovarian Cancer Study Group, Baynes C, Beckman MW, Benitez J, Van Den Berg D, Blot WJ, Bogdanova NV, Bojesen SE, Brenner H, Chang-Claude J, Chia KS, Choi JY, Conroy DM, Cox A, Cross SS, Czene K, Darabi H, Devilee P, Eriksson M, Fasching PA, Figueroa J, Flyger H, Fostira F, García-Closas M, Giles GG, Glendon G, González-Neira A, Guénel P, Haiman CA, Hall P, Hart SN, Hartman M, Hooning MJ, Hsiung CN, Ito H, Jakubowska A, James PA, John EM, Johnson N, Jones M, Kabisch M, Kang D, kConFab Investigators, Kosma VM, Kristensen V, Lambrechts D, Li N, Lifepool Investigators, Lindblom A, Long J, Lophatananon A, Lubinski J, Mannermaa A, Manoukian S, Margolin S, Matsuo K, Meindl A, Mitchell G, Muir K, NBCS Investigators, Nevelsteen I, van den Ouweland A, Peterlongo P, Phuah SY, Pylkäs K, Rowley SM, Sangrajrang S, Schmutzler RK, Shen CY, Shu XO, Southey MC, Surowy H, Swerdlow A, Teo SH, Tollenaar RAEM, Tomlinson I, Torres D, Truong T, Vachon C, Verhoef S, Wong-Brown M, Zheng W, Zheng Y, Nevanlinna H, Scott RJ, Andrulis IL, Wu AH, Hopper JL, Couch FJ, Winqvist R, Burwinkel B, Sawyer EJ, Schmidt MK, Rudolph A, Dörk T, Brauch H, Hamann U, Neuhausen SL, Milne RL, Fletcher O, Pharoah PDP, Campbell IG, Dunning AM, Le Calvez-Kelm F, Goldgar DE, Tavtigian SV, Chenevix-Trench G. (2016). No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing. Journal of Medical Genetics 53(5):298-309.

Decker B*, Davis BW*, Rimbault M, Long AH, Karlins E, Jagannathan V, Reiman R, Parker HG, Drögemüller C, Corneveaux JJ, Chapman ES, Trent JM, Leeb T, Huentelman MJ, Wayne RK, Karyadi DM, Ostrander EA. (2015). Comparison against 186 canid whole genome sequences reveals survival strategies of an ancient clonally transmissible canine tumor. Genome Research 25(11):1646-1655.

Decker B*, Parker HG*, Dhawan D, Kwon EM, Karlins E, Davis BW, Ramos-Vara JA, Bonney PL, McNiel EA, Knapp DW, Ostrander EA. (2015). Homologous mutation to human BRAF V600E is common in naturally occurring canine bladder cancer-Evidence for a relevant model system and urine-based diagnostic test. Molecular Cancer Research 13(6):993-1002.

Decker B and Ostrander EA. (2014). Dysregulation of the homeobox transcription factor gene HOXB13: Role in prostate cancer. Pharmacogenomics and Personalized Medicine 7:193-201. Review.

Karyadi DM, Karlins E, Decker B, vonHoldt BM, Carpintero-Ramirez G, Parker HG, Wayne RK, Ostrander EA. (2013). A copy number variant at the KITLG locus likely confers risk for canine squamous cell carcinoma of the digit. PLOS Genetics 9(3):e1003409.

Schoenebeck JJ, Hutchinson SA, Byers A, Beale HC, Carrington B, Faden DL, Rimbault M, Decker B, Kidd JM, Sood R, Boyko AR, Fondon JW 3rd, Wayne RK, Bustamante CD, Ciruna B, Ostrander EA. (2012). Variation of BMP3 contributes to dog breed skull diversity. PLOS Genetics 8(8):e1002849.

Worthey EA, Mayer AN, Syverson GD Helbling D, Bonacci BB, Decker B, Serpe JM, Dasu T, Tschannen MR, Veith RL, Basehore MJ, Broeckel U, Tomita-Mitchell A, Casper JT, Margolis DA, Bick DP, Hessner MJ, Routes JM, Verbsky JW, Jacob HJ, Dimmock DP. (2011). Making a definitive diagnosis: Successful clinical application of whole exome sequencing in a child with intractable inflammatory bowel disease. Genetics in Medicine 13(3):255-262.

Decker B and Kellermayer MSZ. (2008). Periodically arranged interactions within the myosin filament backbone revealed by mechanical unzipping. Journal of Molecular Biology 377(2):307-310.

Meeting Abstracts

Decker B, Allen J, Luccarini C, Pooley KA, Pharaoh PDP, Dunning AM, Easton DF. (2016). Rare, protein truncating and missense variants in ATM, CHEK2, PALB2, but not XRCC2, confer increased breast cancer risks. American Association for Cancer Research Annual Meeting. New Orleans, Louisiana. Cancer Research.

Decker B, Karyadi DM, Davis BW, Karlins E, Tillmans LS, Stanford JL, Thibodeau SN, Ostrander EA. (2016). Biallelic BRCA2 mutations shape the somatic mutational landscape of aggressive prostate tumors. National Human Genome Research Institute Research Training and Career Development Conference. Bethesda, Maryland.

Decker B*, Davis BW*, Rimbault M, Long AH, Karlins E, Jagannathan V, Reiman R, Parker HG, Drögemüller C, Corneveaux JJ, Chapman ES, Trent JM, Leeb T, Huentelman MJ, Wayne RK, Karyadi DM, Ostrander EA. (2015). Under the radar: Survival strategies of an ancient clonally transmissible canine tumor. Cold Spring Harbor Laboratory Biology of Genomes Conference. Cold Spring Harbor, New York.

Decker B, Karyadi DM, Karlins E, Davis BW, Tillmans L, Stanford JL, Thibodeau SN, Ostrander EA. (2014). Whole genome sequencing of high-grade, treatment-naïve prostate tumors. American Society of Human Genetics Annual Meeting. San Diego, California.

Decker B, Karyadi DM, Karlins E, Tillmans L, Thibodeau SN, Ostrander EA. (2013). Whole genome sequencing of high-grade, treatment-naïve prostate tumors. American Medical Association Medical Student Section Interim Meeting Research Symposium. Washington, DC.

Decker B, Karyadi DM, Karlins E, Tillmans L, Thibodeau SN, Ostrander EA. (2013). Whole genome sequencing of high-grade, treatment-naïve prostate tumors. American Society of Human Genetics Annual Meeting. Boston, Massachusetts.

Decker B, Karyadi DM, Karlins E, Tillmans L, Thibodeau SN, Ostrander EA. (2013). Whole genome sequencing of high-grade, treatment-naïve prostate tumors. National Institutes of Health–Oxford–Cambridge Scholars Program Annual Symposium. Bethesda, Maryland.

Decker B, Lakatos E, Kellermayer MSZ. (2013). Structure of synthetic vertebrate myosin thick filaments explored with high-resolution AFM. Biophysical Society Annual Meeting. Philadelphia, Pennsylvania. Biophysical Journal.

Decker B, Karyadi DM, Karlins E, vonHoldt BM, Carpintero-Ramirez G, Parker HG, Wayne RK, Ostrander EA. (2012). KITLG haplotype confers risk for canine squamous cell carcinoma of the digit. Cold Spring Harbor Laboratory Biology of Genomes Conference. Cold Spring Harbor, New York.

Decker B, Karyadi DM, Karlins E, vonHoldt BM, Carpintero-Ramirez G, Parker HG, Wayne RK, Ostrander EA. (2012). Genetics of canine squamous cell carcinoma of the digit. National Institutes of Health Spring Research Festival. Bethesda, Maryland.

Decker B, DePons J, Taylor B, Dimmock D, Bick D, Jacob HJ, Worthey EA. (2010). Clinical analysis of whole exome sequence data at the Medical College of Wisconsin. Cold Spring Harbor Laboratory Personal Genomes Conference. Cold Spring Harbor, New York.

Decker B, Worthey EA, Jacob HJ, Moreno C. (2009). Genetic determinants of cardiovascular disease: sequencing the rat renin region. Medical College of Wisconsin Student Research Symposium. Milwaukee, Wisconsin.

Decker B and Kellermayer MSZ. (2008). Periodically arranged interactions within the myosin thick-filament backbone revealed by mechanical unzipping. Biophysical Society Annual Meeting. Long Beach, California. Biophysical Journal.

Decker B, Karsai Á, Kellermayer MSZ. (2007). Atomic force microscopy and spectroscopy of synthetic myosin thick filaments. European Muscle Conference. Stockholm, Sweden. Journal of Muscle Research and Cell Motility.

Decker B, Karsai Á, Kellermayer MSZ. (2007). Atomic force microscopy and spectroscopy of synthetic myosin thick filaments. International Conference on Molecular Recognition. Pécs, Hungary.

Decker B, Karsai Á, Kellermayer MSZ. (2007). Atomic force microscopy and spectroscopy of synthetic myosin thick filaments. Sümeg Membrane Transport Conference. Sümeg, Hungary.

Interests

travel, reading, hiking, photography, science, museums, community sports, board games

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