Karen HansenKaren Giles


Research Interests

Thrombosis, Hemostasis and Vascular Biology

Advisor: Lisa Cirillo, PhD, Department of Cell Biology, Neurobiology & Anatomy
Lab page


MS, 2006, Mayo Clinic College of Medicine
Molecular Neuroscience

BS, 2004, College of Idaho
Major: Biology

Research Experience

Medical College of Wisconsin, Milwaukee, WI, 6/2001-8/2011
Summer Research Student
Advisor: Dr. David Harder in collaboration with Dr. Alan Mast, Dr. Anne Hoch
Project: Comparison of Growth Factors and Platelet Concentration and Activation from a Commercial Platelet Rich Plasma Separation System and a Standard Table Top Centrifuge

Medtronic Corporation, Minneapolis, MN, 5/2009-8/2010
CNS Therapy Program Coordinator
Provided project management support for CNS Drug Therapy products in the R&D pipeline. Therapeutic landscapes included Alzheimer’s, Parkinson’s, and Huntington’s Diseases and Pain and Mood Disorders. Developed Good Manufacturing Practice (GMP) plan for producing therapies for Phase I/II Clinical Trials. Helped develop antibody for Alzheimer’s disease and established technology transfer with GMP manufacturer.

Humanetics Corporation, Minneapolis, MN, 2/2008-4/2009
Project Manager
Provided consulting support for product development of pharmacological countermeasures for ionizing radiation.

Acorda Therapeutics and University of Minnesota, St. Paul, MN, 7/2006-1/2008
Biopharmaceutical Engineer and Protein Production Program Manager
Developed GMP purification process for recombinant human monoclonal IgM biotherapeutic for Phase I Clinical Trials for Multiple Sclerosis. Managed protein production and purification projects, including testing of all stages of master cell line development and protein manufacturing.

Mayo Clinic College of Medicine, Rochester, MN, 8/2004-6/2006
Biomedical Research Graduate Student
Advisor: Dr. Joseph Poduslo
Project: Performed pharmacokinetic analysis of the efflux of amyloid beta protein in Alzheimer disease transgenic mice. Helped develop and analyze molecular probe-contrast agent for detection of plaques in parenchyma of Alzheimer brains using MRI.

Mayo Clinic, Rochester, MN, 6/2003-8/2003
Summer Undergraduate Research Fellow
Advisor: Dr. Mark McNiven
Project: Investigated direct interaction between actin-binding proteins, cortactin and dynamin, and their involvement in cell motility in pancreatic cancer. Purified proteins and performed biochemical studies of protein interactions after post-translational modifications.


Giles KE, Kandimalla KK, Ramirez-Alvarado, Poduslo JF. Development of Aβ40 derivatives that do not form fibrils as MRI contrast agents for detecting Alzheimer’s disease amyloid plaques. Journal of Neurochemistry 2005: 94 (Supp 1), 27.


running, cycling, triathlons, Telemark skiing and reading



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Page Updated 01/19/2017