Ishan RoyIshan Roy

Research Interests

Role of chemokines and chemokine receptors in pancreatic cancer invasion and metastasis

Advisor: Michael Dwinell, PhD, Department of Microbiology and Molecular Genetics


BS, 2008, Case Western Reserve University
Major: Biochemistry

PhD, 2014, Medical College of Wisconsin
Microbiology & Molecular Genetics
Thesis: Roles for Chemokines in Pancreatic Cancer Metastasis

Research Experience

Michigan State University, 2003
Advisor: James E. Jackson, PhD
Project: Synthesis, Deuterium Replacement, and Hydrogenation of the Compound HN(CH2CH2NHCOPh)2

Case Western Reserve Medical School,2004-2008
Advisor: Lynn T. Singer, PhD
Project: A longitudinal study of the neurophysiological and psychological effects of fetal exposure to MDMA (ecstasy)

Case Western Reserve University, 2005-2007
Advisor: Michael G. Zagorski, PhD
Project: Elucidating the mechanism of oxidation of the Met35 residue in the Aβ peptide that aggregates in the brains of Alzheimer's disease patients

Cleveland Clinic – Lerner Research Institute, 2007-2008
Advisor: Stanley L. Hazen, MD, PhD
Project: A biochemical investigation of structure/function requirements for the apolipoprotein A1 - lecithin cholesterol acyltransferase interaction loop of discoidal HDL, in conjunction with computer modeling


Roy I, McAllister DM, Gorse E, Dixon K, Piper CT, Zimmerman NP, Getschman AE, Tsai S, Engle DD, Evans DB, Volkman BF, Kalyanaraman B, Dwinell MB. Pancreatic Cancer Cell Migration and Metastasis Is Regulated by Chemokine-Biased Agonism and Bioenergetic Signaling. Cancer Res. 2015 Sep 1;75(17):3529-42. doi: 10.1158/0008-5472.CAN-14-2645. PubMed PMID: 26330165.

Flister MJ, Endres BT, Rudemiller N, Sarkis AB, Santarriaga S, Lemke A, Roy I, Geurts AM, Moreno C, Ran S, Tsaih SW, De Pons J, Carlson D, Tan W, Fahrenkrug SC, Lazarova Z, Lazar J, North PE, LaViolette PS, Dwinell MB, Shull JD, Jacob HJ. CXM - a new tool for mapping breast cancer risk in the tumor microenvironment. Cancer Res. 2014 Aug 29. pii: canres.3212.2013. [Epub ahead of print] PubMed PMID: 25172839.

Roy I, Veldkamp CT, Volkman BF, Dwinell MB. Chemokines in colitis: microRNA control. Gut. 2014 Aug;63(8):1202-4. doi: 10.1136/gutjnl-2013-305886. Epub 2013 Oct 18. PubMed PMID: 24142964.

Roy I, Evans DB, Dwinell MB. Chemokines and chemokine receptors: update on utility and challenges for the clinician. Surgery. 2014 Jun;155(6):961-73. doi: 10.1016/j.surg.2014.02.006. Epub 2014 Feb 8. Review. PubMed PMID: 24856117.

Roy I, Zimmerman NP, Mackinnon AC, Tsai S, Evans DB, Dwinell MB. CXCL12 chemokine expression suppresses human pancreatic cancer growth and metastasis. PLoS One. 2014 Mar 4;9(3):e90400. doi: 10.1371/journal.pone.0090400. eCollection 2014. PubMed PMID: 24594697; PubMed Central PMCID: PMC3942415.

Zimmerman NP, Roy I, Hauser AD, Wilson JM, Williams CL, Dwinell MB. Cyclic AMP regulates the migration and invasion potential of human pancreatic cancer cells. Mol Carcinog. 2013 Sep 24. doi: 10.1002/mc.22091. [Epub ahead of print] PubMed PMID: 24115212; PubMed Central PMCID: PMC4087083.


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