Katherine ZappiaKatherine Zappia

kzappia@mcw.edu

Research Interests

The role of chemokine signaling in the pain and cold hypersensitivity of sickle cell disease
Basic mechanisms of mechanotransduction and pain

Advisor: Cheryl Stucky, PhD, Department of Cell Biology, Neurobiology & Anatomy

Education

BA, 2009, Skidmore College
Major: Neuroscience

PhD, 2016, Medical College of Wisconsin; Department of Cell Biology, Neurobiology & Anatomy
Dissertation: "Mechanisms of Pain and Hypersensitivity in Sickle Cell Disease"

Research Experience

NorthShore University HealthSystem Research Institute, 2009-2010
Advisor: Dr. Gustavo Rodriguez
Project: Ovarian cancer prevention and treatments with cell line and mouse models

NorthShore University HealthSystem Research Institute, 2008-2009
Advisor: Dr. Sidhartha Tan
Project: Modeling cerebral palsy and treatments with fetal rabbit hypoxia-ischemia

Skidmore College, Neuroscience Program, 2007-2009
Advisor: Dr. Hassan López
Project: Effects of cannabinoids on sexual motivation and behaviors in rats

Publications

Rodriguez GC, Turbov J, Rosales R, Yoo J, Hunn J, Zappia KJ, Lund K, Barry CP, Rodriguez IV, Pike JW, Conrads TP, Darcy KM, Maxwell GL, Hamilton CA, Syed V, and Thaete LG (2016). Progestins Inhibit Calcitriol-induced CYP24A1 and Synergistically Inhibit Ovarian Cancer Cell Viability: An Opportunity for Chemoprevention. Gynecologic oncology. DOI: 10.1016/j.ygyno.2016.04.022

Zappia KJ*#, Garrison SR*, Palygin O, Weyer AD, Barabas ME, Lawlor MW, Staruschenko A, and Stucky CL# (2016). Mechanosensory and ATP release deficits following Keratin14-Cre-Mediated TRPA1 deletion despite absence of TRPA1 in murine keratinocytes. PLoS ONE, 11 (3): e0151602.

Weyer AD, Zappia KJ, Garrison SR, O’Hara C, Dodge A, Stucky CL (2016). Nociceptor firing depends on age and pain chronicity. eNeuro, 10.1523.

Zappia KJ*, Garrison SR*, Hillery CA, and Stucky CL (2014). Cold hypersensitivity increases with age in mice with sickle cell disease. PAIN, 155(12): 2476-2485.

López HH, Zappia K, Cushman CL, and Chadwick B (2009). Acute cannabinoid administration attenuates female socio-sexual motivation. Pharmacol Biochem Behav, 94: 482-487.

Meeting Abstracts

Zappia KJ, Hillery CA, and Stucky CL. Chemokine signaling mediates mechanical and cold
hypersensitivity in sickle cell disease. Program No. 602.15 2015 Neuroscience Meeting Planner. Chicago, IL: Society for Neuroscience, 2015.

Zappia KJ, Garrison SR, Hillery CA, and Stucky CL. Chemokine signaling mediates mechanical
and cold hypersensitivity in sickle cell disease. Keystone, CO: 30th Annual MD/PhD National Student Conference, 2015.

Zappia KJ, Garrison SR, Hillery CA, and Stucky CL. Chemokine Signaling and Cold Hypersensitivity of Sickle Cell Disease. Buenos Aires, Argentina: International Association for the Study of Pain, World Congress on Pain, 2014.

Zappia KJ, Garrison SR, Escobar-Klumph M, Hillery CA and Stucky CL. Enhanced cold sensitivity in a mouse model of sickle cell disease. Milwaukee, WI: 2014 Meeting of the Milwaukee Chapter of the Society for Neuroscience. April 29, 2014.

Zappia KJ, Garrison SR, Escobar-Klumph M, Hillery CA and Stucky CL. Cold hypersensitivity and afferent sensitization in a mouse model of sickle cell disease. Program No. 73.04. 2013 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2013.

Escobar-Klumph M, Zappia KJ and Stucky CL. Reactive Oxygen Species (ROS) contribute to TRPV1 sensitivity in a mouse model of sickle cell disease. Program No.741.17. 2013 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience,  2013.

Zappia KJ, Garrison SR, Escobar-Klumph M and Stucky CL. Cold hypersensitivity and afferent sensitization in a mouse model of sickle cell disease. MCW Graduate School Research Poster Session. October 10, 2013

Zappia KJ, Garrison SR, Escobar-Klumph M and Stucky CL. Enhanced cold sensitivity in a mouse model of sickle cell disease. 2013 Meeting of the Milwaukee Chapter of the Society for Neuroscience. May 10, 2013.

Zappia K, Chadwick B, Possidente B, and López HH. Chronic cannabinoid exposure during juvenile development: effects on male sexual behavior & circadian rhythms. Program No. 772.9. 2009 Neuroscience Meeting Planner. Chicago, IL: Society for Neuroscience, 2009. Online.

Zappia K, Chadwick B, Cushman CL, and López HH. Cannabinoids and female sexual motivation: Interactions with the opioid system. Skidmore College Academic Festival. April 30, 2009.

López HH, Cushman CL, Chadwick B, and Zappia K. The effect of acute and chronic cannabinoid administration on female sexual motivation. Washington, D.C.: Society for Neuroscience, 2008.

Interests

cross country skiing, triathlons, hiking and biking

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