Scott BugenhagenScott Bugenhagen

sbugenha@mcw.edu

Research Interests

Physiology, Biomedical Engineering

Advisor: Dan Beard, PhD, Department of Physiology

Education

BS, 2007, Milwaukee School of Engineering
Major: Biomedical Engineering

PhD, 2014, Medical College of Wisconsin
Thesis: “The Role of Metabolic Dysfunction in Heart Failure”

Research Experiences

Illinois Institute of Technology REU program/University of Chicago, 2006
Advisor: Dr. Louis Philipson
Project: Insulin vesicle trafficking in response to GLP-1 in MIN6 insulinoma cells

Medical College of Wisconsin SPUR program, 2005
Advisor: Dr. Mingyu Liang
Project: Molecular networks in Dahl salt-sensitive hypertension

Publications

Pettersen KH, Bugenhagen SM, Nauman J, Beard DA, Omholt SW (2013) Arterial stiffening provides sufficient explanation for primary hypertension. PLoS Comput Biol. 10:e1003634

Beard DA, Pettersen KH, Carlson BE, Omholt SW, Bugenhagen SM (2013) A computational analysis of the long-term regulation of arterial pressure. F1000Res 2:208

Tewari SG, Bugenhagen SM, Wang Z, Schreier DA, Carlson BE, Chesler NC, Beard DA (2013) Analysis of cardiovascular dynamics in pulmonary hypertensive C57BL6/J mice. Front Physiol 4:355

Bugenhagen SM, Beard DA (2012) Specification, construction, and exact reduction of state transition system models of biochemical processes. J Chem Phys 137:154108

Vinnakota KC, Bugenhagen SM (2012) Optimization and parameter estimation: genetic algorithms. In W Dubitzky et al. (Ed.), Encyclopedia of Systems Biology (Volume 1), Springer-Verlag, New York, LLC

Bugenhagen SM, Cowley AW Jr, Beard DA. Identifying physiological origins of baroreflex dysfunction in salt-sensitive hypertension in the Dahl SS rat. Physiol Genomics. 2010 Jun;42(1):23-41.

Liang M, Lee NH, Wang H, Greene AS, Kwitek AE, Kaldunski ML, Luu TV, Frank BC, Bugenhagen S, Jacob HJ, Cowley AW Jr (2008) Molecular networks in Dahl salt-sensitive hypertension based on transcriptome analysis of a panel of consomic rats. Physiol Genomics 34:54-64

Zhao M, Li Z, Bugenhagen S (2008) 99mTc-labeled duramycin as a novel phosphatidylethanolamine-binding molecular probe. J Nucl Med 49:1345-1352

Meeting Abstracts

Scott M Bugenhagen and Daniel A Beard. The role of metabolic dysfunction in heart failure. The 15th International Conference on Biomedical Engineering, Singapore, 2013. Oral presentation.

Klas H Pettersen, Scott M Bugenhagen, Javaid Nauman, Daniel A Beard, and Stig W Omholt. Arterial stiffening provides sufficient explanation for primary hypertension. The 15th International Conference on Biomedical Engineering, Singapore, 2013. Oral presentation.

Scott M Bugenhagen and Daniel A Beard. The role of metabolic dysfunction in heart failure. Cardiac Physiome Workshop, Bar Harbor, 2013. Oral presentation.

Scott M Bugenhagen and Daniel A Beard . The role of metabolic dysfunction in heart failure. NIGMS National Centers for Systems Biology Annual Meeting, Bethesda, 2013. Poster presentation.

Scott M Bugenhagen and Daniel A Beard. A simplified state model of the cardiac Ca2+/calmodulin-dependent protein kinase II holoenzyme. Cardiac Physiome Workshop, San Diego, 2012. Poster presentation.

Scott M Bugenhagen and Daniel A Beard. Scalability and dimension reduction in multiscale models of physiological systems. SIAM Conference on the Life Sciences (LS12), San Diego, 2012. Oral presentation.

Scott M Bugenhagen, Shivendra G Tewari, Allen W Cowley, Daniel A Beard. Nonlinear model identification of the baroreflex system in rat. National MD/PhD Student Conference, Keystone, 2012. Poster Presentation.

Scott M Bugenhagen and Daniel A Beard. Specification, construction, and exact reduction of state transition system models of biochemical processes. IMAG Multiscale Modeling Working Group Webinar Series, Milwaukee, 2012. Webinar presentation. Archived recording available for download at https://webmeeting.nih.gov/p65832122/.

Scott M Bugenhagen and Daniel A Beard. Specification, construction, and exact reduction of state transition system models of biochemical processes. NIGMS National Centers for Systems Biology Annual Meeting, Chicago, 2012. Poster presentation.

Scott M Bugenhagen and Daniel A Beard. Specification, construction, and exact reduction of state transition system models of biochemical processes. Biophysical Society 56th Annual Meeting, San Diego, 2012. Poster presentation.

Interests

sailing, golf, wrestling, music, movies

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