Understanding human cytomegalovirus kinase involvement in control of viral promoters
Advisor: Scott Terhune, PhD, Department of Microbiology and Molecular Genetics
BS, 2008, University of Wisconsin-Milwaukee
Majors: Biology and Biochemistry
PhD, 2014, Medical College of Wisconsin
Thesis: "Defining the Mechanism of Cytomegalovirus Kinase-mediated Regulation of Viral Gene Expression and the Therapeutic Implications"
Advisor: Dr. Mark McBride
Project: Characterization of taxis genes in Flavobacterium johnsoniae
Wisconsin Lutheran College, 2005
Advisor: Dr. Anderson
Project: Studying the macroinvertebrate population in the Menomonee River to access water quality in the Menomonee River
Bigley TM, Reitsma JM, Terhune SS. An Antagonistic Relationship between Human Cytomegalovirus pUL27 and pUL97 Activities during Infection. J. Virol. 2015 Jul (In Press).
Bretl DJ, Bigley TM, Terhune SS, Zahrt TC. The MprB extracytoplasmic domain negatively regulates activation of the Mycobacterium tuberculosis MprAB two-component system. J Bacteriol. 2013 Nov 1. [Epub ahead of print]
Mounce BC, Mboko WP, Bigley TM, Terhune SS, Tarakanova VL. A conserved gammaherpesvirus protein kinase targets histone deacetylases 1 and 2 to facilitate viral replication in primary macrophages. J Virol. 2013 Jul;87(13):7314-25. Epub 2013 Apr 24.
Bigley TM, Reitsma JM, Mirza SP, Terhune SS. Human cytomegalovirus pUL97 regulates the viral major immediate early promoter by phosphorylation-mediated disruption of histone deacetylase 1 binding. J Virol. 2013 Jul;87(13):7393-408. Epub 2013 Apr 24. (Spotlight Article).
Savaryn JP, Reitsma JM, Bigley TM, Halligan BD, Qian Z, Yu D, Terhune SS. Human cytomegalovirus pUL29/28 and pUL38 repression of p53-regulated p21CIP1 and caspase 1 promoters during infection. J Virol. 2013 Mar;87(5):2463-74. Epub 2012 Dec 12.
Lam V, Bigley TM, Terhune SS, Wakatsuki T. A method for quantifying mechanical properties of tissue following viral infection. PLoS One. 2012;7(8):e42197. Epub 2012 Aug 3.
Tarakanova VL, Stanitsa E, Leonardo SM, Bigley TM, Gauld SB. Conserved gammaherpesvirus kinase and histone variant H2AX facilitate gammaherpesvirus latency in vivo. Virology. 2010 Sep 15;405(1):50-61. Epub 2010 Jun 16.
sports, running, biking, music (listening, shows, playing guitar), hanging out with my wife and dogs