Zach ShaheenZach Shaheen

zshaheen@mcw.edu

Research Interests

Our lab is interested in uncovering cellular processes that mediate dysfunction or destruction of pancreatic β-cells in Type 1 and Type 2 Diabetes Mellitus. Environmental triggers (including viral infections) may be involved in autoimmune destruction of β-cells in Type 1 Diabetes, and I am investigating the role of viral-activated signaling pathways and inflammatory responses on β-cell survival.

My long term clinical and research goals are to train in Pediatrics and to study autoinflammatory and autoimmune disease.

Education

PhD, 2016, Medical College of Wisconsin
Area of study: Innate immune responses to viral infection in the context of autoimmune diabetes pathogenesis

BA, 2009, College of Saint Benedict / Saint John’s University (CSB/SJU)
Major: Biochemistry
Minor/Concentrations: Political Science, Pre-Med

Research Experience

MCW Department of Biochemistry 2011-2016
Advisor: Dr. John Corbett
Thesis: Elucidating macrophage and β-cell responses to viral infection: evidence for CCR5-dependent expression of inflammatory genes as a novel anti-viral response

CSB/SJU, 2006-2009
Advisor: Dr. Michael Reagan
Project: Examination of ethylation DNA damage on RNA Polymerase II mediated RNA synthesis in the yeast Saccharomyces cerevisiae

CSB/SJU, 2009
Advisor: Dr. David Mitchell
Project (Literature Review): The Fountain of Youth – A Biochemical Explanation of physiological aging from environmental and endogenous oxidative stressors

Interests & Hobbies

ice hockey, tennis, frisbee golf, canoe camping, fishing, hiking, anything outdoors, cards (poker)
music: play percussion/drum set, guitar, piano, and compose music and lyrics
civic activism

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