Li Lily Wang, PhD

Assistant Professor
Microbiology and Molecular Genetics & Cancer Center
Medical College of Wisconsin

Research Focus: Immune regulation mediated by negative checkpoint regulators; Cancer immunotherapy

PhD: Dartmouth Medical School (2003) Biochemistry

Wang Laboratory


Research in the Wang lab focuses on immune regulation mediated by the immune-checkpoint proteins, such as VISTA. We apply preclinical tumor models to investigate the mechanisms whereby VISTA controls the anti-tumor immunity, and design innovative immunotherapeutic strategies for cancer treatment.

 

Figure 1 B7 Family co-signaling molecules regulate T cell responses

Figure 1. The B7 family co-signaling molecules regulate T cell responses.  The co-inhibitory molecules, such as CTLA-4, PD-1, and VISTA are also called "immune-checkpoints".  They play critical role in maintaining T cell peripheral tolerance and controlling autoimmunity.

 

 

Figure 2 Research in Wang lab addresses the immune-regulatory for of VISTA

Figure 2. Research in the Wang lab addresses the immune-regulatory role of a novel immune-checkpoint molecule, called V-domain Immunoglobulin Suppression of T cell Activation (VISTA). VISTA is expressed on multiple immune cell types, and suppresses the anti-tumor immunity.

 

 

Figure 3. VISTA-blocking monoclonal antibody effectively enhances tumor-reactive T cell response, and can synergize with cancer vaccine to eradicate tumor cells.

 

Current Funding

  • 1R01CA164225   Wang (PI)   07/2012 - 06/2017
    Agency: NIH/NCI
    Title: VISTA, a novel checkpoint that suppresses anti-tumor T cell responses
    The goals are to define the molecular and cellular mechanisms of VISTA-mediated immune supression in cancer.
     
  • CA130351   Wang (PI)   07/2014 - 06/2016
    Agency: Department of Defense, Peer Reviewed Cancer Research Program (PRCRP)
    Title: VISTA Blockade Synergizes with TLR-Agonist-Based Vaccine for Melanoma Prevention and Therapy
    The goals are to optimize a combinatorial therapeutic platform for melanoma and determine the mechanisms of synergistic efficacy.
     
  • 1R01ES024745   Havrda (PI)   Wang (co-PI)   07/2015 – 06/2020
    Agency: NIEHS
    Title: Mechanisms of rotenone-induced neuro-inflammation and Parkinsonism in aging mice
    The goal of this project is to evaluate the role of astrocytes in mediating pro-inflammatory changes resulting from ingestion of rotenone in mice.
     
  • CA198719   Spaller (PI)   Wang (co-PI)   04/2016 – 03/2018
    Agency: NIH
    Title: Discovery of Modulators for the Immune Checkpoint Regulatory Protein VISTA

 

Literature for Cancer Immunotherapy

http://www.nature.com/subjects/cancer-immunotherapy
http://www.nature.com/reviews/focus/tumourimmunology/index.html
http://www.nature.com/nrc/journal/v12/n4/full/nrc3239.html


Recent Publications

 

Contact Information

Li Lily Wang, PhD
Department of Microbiology and Molecular Genetics
Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53226

lilywang@mcw.edu

(414) 955-7489

Office  BSB-204 (Basic Science Building)
Lab  BSB-215 (Basic Science Building)

 

Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53226
(414) 955-8296
Directions & Maps
© 2016

Page Updated 01/28/2016
Top