Li Lily Wang, PhDLi Lily Wang, PhD

Assistant Professor
Microbiology and Molecular Genetics & Cancer Center
Medical College of Wisconsin

Research Focus: Immune regulation mediated by negative checkpoint regulators; Cancer immunotherapy

PhD: Dartmouth Medical School (2003) Biochemistry

Wang Laboratory


Research in the Wang lab focuses on immune regulation mediated by the immune-checkpoint proteins, such as VISTA. We apply preclinical tumor models to investigate the mechanisms whereby VISTA controls the anti-tumor immunity, and design innovative immunotherapeutic strategies for cancer treatment.

 

Figure 1 B7 Family co-signaling molecules regulate T cell responses

Figure 1. The B7 family co-signaling molecules regulate T cell responses.  The co-inhibitory molecules, such as CTLA-4, PD-1, and VISTA are also called "immune-checkpoints".  They play critical role in maintaining T cell peripheral tolerance and controlling autoimmunity.

 

 

Figure 2 Research in Wang lab addresses the immune-regulatory for of VISTA

Figure 2. Research in the Wang lab addresses the immune-regulatory role of a novel immune-checkpoint molecule, called V-domain Immunoglobulin Suppression of T cell Activation (VISTA). VISTA is expressed on multiple immune cell types, and suppresses the anti-tumor immunity.

 

 

VISTA-blocking monoclonal antibody effectively enhances tumor-reactive T cell response

Figure 3. VISTA-blocking monoclonal antibody effectively enhances tumor-reactive T cell response, and can synergize with cancer vaccine to eradicate tumor cells.

 

Literature for Cancer Immunotherapy

http://www.nature.com/subjects/cancer-immunotherapy
http://www.nature.com/reviews/focus/tumourimmunology/index.html
http://www.nature.com/nrc/journal/v12/n4/full/nrc3239.html


Recent Publications

 

Contact Information

Li Lily Wang, PhD
Department of Microbiology and Molecular Genetics
Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53226

lilywang@mcw.edu

(414) 955-7489

Office  BSB-204 (Basic Science Building)
Lab  BSB-215 (Basic Science Building)

 

Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53226
(414) 955-8296
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Page Updated 06/06/2016
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