Milan Joksimovic, PhD
Department of Cell Biology, Neurobiology and Anatomy
Medical College of Wisconsin
Phone: (414) 955-7635
Fax: (414) 955-6517
My name is Milan Joksimovic and I am an Assistant Professor at the Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin. I have received my BS degree at the University of Belgrade, Serbia, PhD at the Iowa State University, Ames, IA, and completed a postdoctoral training at the Northwestern University, Chicago, IL.
My scientific background is at the intersection of neuroscience, developmental biology, and genetics. I am particularly interested in development of the midbrain dopaminergic neurons (mDA). Aberrant function of these mDA underlies a broad spectrum of disorders including Parkinson’s disease – a devastating neurodegenerative disorder that affects more than one million people in the US. To generate effective therapeutics, it is crucial to decipher molecular mechanisms underlying generation of these neurons including proliferation, cell fate specification, migration, and correct axonal projections of mDA. In an attempt to provide answers to some of these basic questions, my laboratory uses conditional mouse genetics, genetic fate mapping, and various molecular biology techniques.
Joksimovic, M.,Anderegg, A., Roy, A., Campochiaro, L., Yun, B., Kittappa, R., McKay, R., Awatramani, R., 2009. Spatiotemporally separable Shh domains in the midbrain define distinct dopaminergic progenitor pools. Proc. Natl. Acad. Sci. USA. 106(45):19185-90.
Joksimovic, M.,Yun, B., Kittappa, R., Anderegg, A., Chang, W., Taketo, M., McKay, R.D.G., Awatramani, R.B., 2009. Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis. Nature Neuroscience. 12(2):125-31.