Center for Patient Care and Outcomes Research (PCOR)

Raymond G. Hoffmann, PhD Professor, Biostatistics

Professor Hoffmann has co-authored or authored over 200 papers applying statistical methods to biomedical problems. He is an expert statistical methods for neuroimaging, connectionist neural networks for modeling addiction, time series analysis, statistical methods for epidemiology and analysis of variance involving repeated measures. He has investigated binary time series, graphical methods for identifying nonlinear binary time series, categorical nonlinear time series and models for the pulsatile secretion of insulin. He has extensive experience with the design and planning of community studies. He also is interested in cardiovascular epidemiology and has investigated the effects of mediating factors such as alcohol, body fat distribution and hormone profile on the development of occlusive heart disease.

Representative Publications

Hoffmann R.G.  Estimating change in the proportion of sexually inactive: A Bayesian Approach.  Proceeding of the Statistics in Epidemiology  Section, American Statistical Association, 1999.

Bloom A,  Hoffmann RG, Fuller SA,  Pankiewicz J, Harsch HH, and Stein EA. An  Activation  Detection Procedure for  Drug-Induced Changes in Functional MRI Signal Using a Pharmacokinetic Model.  Neuroimage 1999.

Woehlck HJ. Connolly LA. Cinquegrani MP. Dunning MB 3rd. Hoffmann RG. Acute smoking increases ST depression in humans during general anesthesia. Anesth Analg 89(4):856-60, 1999

Lanska DJ. Hoffmann RG. Seasonal variation in stroke mortality rates. [published erratum appears in Neurology 1999 Jun 10;52(9):1952] Neurology 52(5):984-90, 1999.

Sheehan, P.M., Fastovsky, D.E., Barreto, C., Hoffmann, R.G., Dinosaur abundance was not declining in a "3 m gap" at the top of the Hell Creek Formation, Montana and North Dakota. Geology v. 28, p. 523-526. 2000

Sikkema KJ. Kalichman SC. Hoffmann R. Koob JJ. Kelly JA. Heckman TG. Coping strategies and emotional wellbeing among HIV-infected men and women experiencing AIDS-related bereavement. AIDS Care 12(5):613-24, 2000

Slyper AH. Shadley JD. van Tuinen P. Richton SM. Hoffmann RG. Wyatt DT. A study of chromosomal aberrations and chromosomal fragility after recombinant growth hormone treatment. Pediatr Res 47(5):634-9, 2000.

Warren SJ. Lin MS. Giudice GJ. Hoffmann RG. Hans-Filho G. Aoki V. Rivitti EA. Santos V. Diaz LA.  The prevalence of antibodies against desmoglein 1 in endemic pemphigus foliaceus in Brazil. Cooperative Group on Fogo Selvagem Research [see comments].  N Engl J Med 343(1):23-30, 2000 Jul 6.

Nattinger AB. Hoffmann RG. Kneusel RT. Schapira MM. Relation between appropriateness of primary therapy for early-stage breast carcinoma and increased use of breast-conserving surgery. Lancet 356(9236):1148-1153, 2000 September 30.

Otto-Salaj LL. Kelly JA. Stevenson LY. Hoffmann R. Kalichman SC. Outcomes of a randomized small-group HIV prevention intervention trial for people with serious mental illness. Community Ment Health J 37(2):123-44, 2001