The Redox Biology Program unites researchers interested in the role of redox processes in physiology and pathology.
Many biological processes involve the movement of electrons, and every time an electron moves, something gets reduced, and something gets oxidized.
Redox processes are essential to respiration and the generation of cellular ATP. Overt cellular damage can result from the overexposure of cells to environmental oxidants or the overproduction of similar oxidants by the cell itself (often termed "oxidative stress").
However, it has become clear that redox reactions in cells, and the control of redox homeostasis, modulate a plethora of cellular signaling events through protein post-translational modifications.
The control of apoptosis, proliferation, and migration of cells has been shown to be modulated at multiple levels by redox processes, usually (though not exclusively) through the oxidation/reduction/modification of protein thiol groups.
If you are interested in redox biology, and would like to be a part of this program, please contact us.
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Special Redox Biology Program Seminar
E. Dale Abel, MD, PhD, will deliver a seminar, Cardiac Mitochondrial Dysfunction in Obesity and Diabetes - Central Role of Oxidative Stress, 11 am Dec. 6, 2013 in HRC 1210.
Dr. Abel is Director of the Fraternal Order of Eagles Diabetes Research Center in the University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, Iowa.
He also holds the John B. Stokes III Chair in Diabetes Research.
Dr. Abel’s current research interests focus on elucidating the molecular mechanisms leading to cardiac dysfunction in diabetes and the regulation of myocardial growth and metabolism by insulin signaling.
Michael C. Larson Successfully Defends Dissertation
Michael Larson, a Medical Scientist Training Program and Department of Biophysics student, successfully defended his dissertation, “Examining phosphatidylethanolamine externalization on cells and microparticles in hemolysis and hemolytic anemia,” Dec. 2, 2013.
Neil Hogg, PhD, and Cheryl Hillery, MD, were his advisors. Andrew Greene, PhD, Jeannette Vasquez-Vivar, PhD, and Mark Gladwin, MD, also served on his dissertation committee.
Larson published three manuscripts and has another in press. He is also submitting a number of papers to peer-reviewed journals.
He will resume his medical studies next month and expects to receive his medical degree in 2016.
■ David Gutterman, MD, notes in a MedPage Today article that additional research is needed to confirm a study reported in CHEST that found that the perioperative administration of beta-blockers during non-cardiac surgery may put patients at risk of acute heart problems.
■ The Society for Free Radical Biology and Medicine appointed Neil Hogg, PhD, President-Elect. He will serve in this role until 2014, and then serve as President of the society for two years.
■ The National Heart, Lung and Blood Institute awarded Kirkwood A. Pritchard, PhD, a four-year, $2.5 million award to develop a more precise clinical test for predicting a patient's risk of developing heart disease
Savitha Sethumadhavan, PhD, was honored at MCW’s annual Women in Science Awards Luncheon Oct. 17, 2013. She is the recipient for this year’s $1,000 Edward J. Lennon, MD, Outstanding Woman Postdoctoral Researcher award.
Dr. Sethumadhavan is a biochemist working Jeannette Vasquez Vivar's laboratory.
The American Heart Association awarded her in January with a third-year fellowship to examine the link between mtDNA variants and alterations in cardiac respiratory reserve capacity and oxidant stress in diabetes. This is a collaboration between the Redox Biology Program Vasquez-Vivar lab and the Jacob and Lazar labs in the Human and Molecular Genetics Center.