The Redox Biology Program unites researchers interested in the role of redox processes in physiology and pathology.
Many biological processes involve the movement of electrons, and every time an electron moves, something gets reduced, and something gets oxidized.
Redox processes are essential to respiration and the generation of cellular ATP. Overt cellular damage can result from the overexposure of cells to environmental oxidants or the overproduction of similar oxidants by the cell itself (often termed "oxidative stress").
However, it has become clear that redox reactions in cells, and the control of redox homeostasis, modulate a plethora of cellular signaling events through protein post-translational modifications.
The control of apoptosis, proliferation, and migration of cells has been shown to be modulated at multiple levels by redox processes, usually (though not exclusively) through the oxidation/reduction/modification of protein thiol groups.
If you are interested in redox biology, and would like to be a part of this program, please contact us.
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Redox Biology Program Awards Two Investigators Funding
The Medical College of Wisconsin (MCW) Redox Biology Program granted Advancing a Healthier Wisconsin (AHW) subawards to Allison Ebert, PhD, and Andreas Beyer, PhD. These $5,000 awards are for supplies and services for ‘new idea’ projects in the area of redox and oxidative biology.
Department of Cell Biology, Neurobiology and Anatomy Assistant Professor Allison Ebert will use the funding for her project, “Exploring Cell-Specific Mitochondrial Function in Neurological Disease.” The primary goal of her project is to determine if mitochondrial respiration can be measured in different cell types generated from pluripotent stem cells and if differences in respiration measures correlate to cell vulnerability in various neurodegenerative diseases.
Dr. Beyer, an assistant professor in the Department of Cardiovascular Medicine, was awarded $5,000 for his project, “Role of Endothelial Telomerase Activity as a Novel Regulator of Redox Hemostasis.” His proposal focuses on endothelial changes in relation to cellular localization of the telomerase subunit TERT.
“The proposed investigations will provide useful, novel tool data for future application of external funding. We believe this project is of great value to the greater community and is applicable for multiple disease studies,” he said.
Both investigators received funding because their projects aligned with the AHW five-year plan research priorities.
Advancing a Healthier Wisconsin is an endowment of the Medical College of Wisconsin committed to improving the health of Wisconsin residents.
Aimee L. Landar, PhD, presented “Cell signaling by electrophiles: physiology, pathology, and pharmacology” March 25. Dr. Landar is an assistant professor in the Department of Pathology and the Comprehensive Cancer Center at the University of Alabama at Birmingham.
Save the Date
Redox Biology Program Biochemist Honored
Savitha Sethumadhavan, PhD, was honored at MCW’s annual Women in Science Awards Luncheon Oct. 17, 2013. She is the recipient for this year’s $1,000 Edward J. Lennon, MD, Outstanding Woman Postdoctoral Researcher award.