The Redox Biology Program unites researchers interested in the role of redox processes in physiology and pathology.
Many biological processes involve the movement of electrons, and every time an electron moves, something gets reduced, and something gets oxidized.
Redox processes are essential to respiration and the generation of cellular ATP. Overt cellular damage can result from the overexposure of cells to environmental oxidants or the overproduction of similar oxidants by the cell itself (often termed "oxidative stress").
However, it has become clear that redox reactions in cells, and the control of redox homeostasis, modulate a plethora of cellular signaling events through protein post-translational modifications.
The control of apoptosis, proliferation, and migration of cells has been shown to be modulated at multiple levels by redox processes, usually (though not exclusively) through the oxidation/reduction/modification of protein thiol groups.
If you are interested in redox biology, and would like to be a part of this program, please contact us.
■ Charles Myers, PhD, and Rodney Willoughby, MD, received a $5,000 Advancing a Healthier Wisconsin Sub-Award.
■ David Gutterman, MD, delivered the plenary lecture, “Endothelium-Dependent Dilation in the Human Microcirculation: A Window Into Vascular Health and Disease,” March 1, 2013, at the West Virginia University EJ Van Liere Memorial Convocation and HSC Research Day.
■ The Society for Free Radical Biology and Medicine appointed Neil Hogg, PhD, President-Elect. He will serve in this role until 2014, and then serve as President of the society for two years.
■ The National Heart, Lung and Blood Institute awarded Kirkwood A. Pritchard, PhD, a four-year, $2.5 million award to develop a more precise clinical test for predicting a patient's risk of developing heart disease
The American Heart Association awarded Postdoctoral Fellow Savitha Sethumadhavan, PhD, in January with a third-year fellowship to examine the link between mtDNA variants and alterations in cardiac respiratory reserve capacity and oxidant stress in diabetes. This is a collaboration between the Redox Biology Program Vasquez-Vivar lab and the Jacob and Lazar labs in the Human and Molecular Genetics Center.