David Harder, PhD
David R. Harder, PhD, is a Professor in the Departments of Physiology, Medicine, and Pediatrics. In addition to serving as the Kohler Company Professor in Cardiovascular Research, he is an Associate Dean for Research Mentoring.
The Harder Laboratory is focusing on two things.
Autoregulation of Cerebral Blood Flow: The main goal of this project is to define the genetic factor responsible for autoregulation of cerebral blood flow, including the signaling cascades and ionic mechanisms that mediate pressure-induced myogenic tone.
Regulating Cerebral Microcirculation by Astrocytes: The goal of this project is to define mechanisms by which epoxygenase metabolites of astrocytes inhibit autoregulatory vasoconstriction of cerebral arteries. The major goal of this project is to define some of the cellular and ionic mechanisms through which superoxide and hydrogen peroxide modulate myogenic autoregulation of cerebral blood flow.