Redox Biology Program

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Balaraman (Raman) Kalyanaraman, PhD

Phone:  414-955-4002  
Fax:      414-955-6512
Email:   balarama@mcw.edu

Kalyanaraman Laboratory

Balaraman (Raman) Kalyanaraman, PhD, is the Chairman and Professor in the Department of Biophysics. He is the Harry R. & Angeline E. Quadracci Professor in Parkinson’s Research at the Medical College of Wisconsin. 

His research interests are centered on the application of EPR in free radical biology and understanding the role of free radicals in signal transduction and apoptosis. His specific research areas are outlined below. He has served as an Associate Editor for Free Radical Research and the Biochemical Journal, and currently is Associate Editor for Free Radicals in Biology and Medicine.

Chemistry and Biophysics

  • Detection of free radicals by EPR spin-trapping, fluorescence, optical stopped-flow, and HPLC techniques
  • Syntheses of mitochondrially targeted spin traps, spin labels, and ROS-specific fluorescence probes
  • EPR/ENDOR/NMR studies of active site geometry of redox-active enzymes (e.g., superoxide dismutase)
  • Nitration of tyrosine- and tryptophan-containing peptides and protein (e.g., synucleins) in biological membranes

Mechanism of Signal Transduction/Cell Signaling

  • Nitric oxide and cyclic nucleotide-dependent cell signaling and proteasomal activation
  • Oxidant-induced iron signaling and apoptosis
  • Redox proteomics
  • Chemotherapeutic drug toxicity and prevention (e.g., doxorubicin); mechanism of apoptosis in tumor cells and normal cells

Mechanism of Disease

  • Role of mitochondria-derived oxidants in chemically induced Parkinsonism (e.g., MPTP, rotenone) in cell culture and animal models; mechanism of protein aggregation, proteosomal dysfunction, and apoptotic neuronal cell death
  • Oxidative stress and apoptosis induced by amyotrophic lateral sclerosis (Lou Gehrig's disease)/SOD1 mutants in cell culture and animal models; therapeutic intervention of disease progression in a G93A-transgenic animal model

Dr. Kalyanaraman discusses targeted antioxidant molecule research at the Medical College of Wisconsin:

 

 

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