Redox Biology Program

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Spring 2013

The Redox Biology Program hosts a monthly "Works-in-Progress" session.

In addition, Albert Girotti, PhD, hosts a noon to 1 p.m. Thursday journal club each week in Room 376 of the Biochemistry Department.

The focus of the Oxidative Signaling Journal Club is to examine recent manuscripts regarding oxidative signaling pathways with responses ranging from cell proliferation to cell senescence or death. Novel sensing mechanisms and sensor proteins responding to ROS or RNS redox are of particular interest.

 

Oxidative Signaling Journal Club

 

Date and Speaker Title of Manuscript Presented
Jan. 11
Katarzyna Broniowska, PhD
Postdoctoral Fellow
Department of Biophysics
Doulias PT, Tenopoulou M, Greene JL, Raju K, Ischiropoulos H. Nitric oxide regulates mitochondrial fatty acid metabolism through reversible protein S-nitrosylation. Sci Signal. 2013 Jan 1;6(256):rs1
Jan. 18
Anne Diers, PhD
Postdoctoral Fellow
Department of Biophysics
Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison B 3rd, Stockwell BR. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012 May 25;149(5):1060-72.
Jan. 25
John Corbett, PhD
Chairman and Professor
Department of Biochemistry
Lee HJ, Mariappan MM, Feliers D, Cavaglieri RC, Sataranatarajan K, Abboud HE, Choudhury GG, Kasinath BS. Hydrogen sulfide inhibits high glucose-induced matrix protein synthesis by activating AMP-activated protein kinase in renal epithelial cells. J Biol Chem. 2012 Feb 10;287(7):4451-61.
Feb. 1
Brian Dranka, PhD
Postdoctoral Fellow
Department of Biophysics
Xun Z, Rivera-Sánchez S, Ayala-Peña S, Lim J, Budworth H, Skoda EM, Robbins PD, Niedernhofer LJ, Wipf P, McMurray CT. Targeting of XJB-5-131 to mitochondria suppresses oxidative DNA damage and motor decline in a mouse model of Huntington's disease. Cell Rep. 2012 Nov 29;2(5):1137-42
Feb. 8
Reshma Bhowmick, PhD
Research Scientist
Department of Biochemistry
Hung HI, Schwartz JM, Maldonado EN, Lemasters JJ, Nieminen AL. Mitoferrin-2-dependent mitochondrial iron uptake sensitizes human head and neck squamous carcinoma cells to photodynamic therapy. J Biol Chem. 2013 Jan 4;288(1):677-86. Epub 2012 Nov 7.
Feb. 15
Witold Korytowski, PhD
Assistant Professor
Department of Biochemistry
Straub AC, Lohman AW, Billaud M, Johnstone SR, Dwyer ST, Lee MY, Bortz PS, Best AK, Columbus L, Gaston B, Isakson BE. Endothelial cell expression of haemoglobin α regulates nitric oxide signalling. Nature. 2012 Nov 15;491(7424):473-7. Epub 2012 Oct 31.
Feb. 22
Ching-Fang Chang
Graduate Student
Department of Biophysics
Trachootham D, Chen G, Zhang W, Lu W, Zhang H, Liu J, Huang P. Loss of p53 in stromal fibroblasts promotes epithelial cell invasion through redox-mediated ICAM1 signal. Free Radic Biol Med. 2013 May;58:1-13. Epub 2013 Jan 29.
March 1
Zhen Ding
Graduate Student
Department of Biophysics
Mao K, Chen S, Chen M, Ma Y, Wang Y, Huang B, He Z, Zeng Y, Hu Y, Sun S, Li J, Wu X, Wang X, Strober W, Chen C, Meng G, Sun B. Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock. Cell Res. 2013 Feb;23(2):201-12. Epub 2013 Jan 15.
March 8
Jeannette Vasquez-Vivar, PhD Associate Professor
Department of Biophysics
Yu W, Dittenhafer-Reed KE, Denu JM. SIRT3 protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status. J Biol Chem. 2012 Apr 20;287(17):14078-86. Epub 2012 Mar 13.
March 22
Albert Girotti, PhD
Professor
Department of Biochemistry
Dando I, Fiorini C, Pozza ED, Padroni C, Costanzo C, Palmieri M, Donadelli M. UCP2 inhibition triggers ROS-dependent nuclear translocation of GAPDH and autophagic cell death in pancreatic adenocarcinoma cells. Biochim Biophys Acta. 2013 Mar;1833(3):672-9. Epub 2012 Nov 2.
March 29
Savitha Sethumadhavan, PhD Postdoctoral Fellow
Department of Biophysics
Nikiforov A, Dölle C, Niere M, Ziegler M. Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation. J Biol Chem. 2011 Jun 17;286(24):21767-78. Epub 2011 Apr 19.
April 12
Cara Manlandro
Graduate Student
Department of Biochemistry
Mo JS, Yoon JH, Ann EJ, Ahn JS, Baek HJ, Lee HJ, Kim SH, Kim YD, Kim MY, Park HS. Notch1 modulates oxidative stress induced cell death through suppression of apoptosis signal-regulating kinase 1. Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6865-70. Epub 2013 Apr 8.
April 26
Brian Dranka, PhD
Postdoctoral Fellow
Department of Biophysics
Singh S, Zhuo M, Gorgun FM, Englander EW. Overexpressed neuroglobin raises threshold for nitric oxide-induced impairment of mitochondrial respiratory activities and stress signaling in primary cortical neurons. Nitric Oxide. 2013 Aug 1;32:21-8. Epub 2013 Apr 13.
May 17
Ching-Fang Chang
Graduate Student
Department of Biophysics
Engelman R, Weisman-Shomer P, Ziv T, Xu J, Arnér ES, Benhar M. Multilevel regulation of 2-Cys peroxiredoxin reaction cycle by S-nitrosylation. J Biol Chem. 2013 Apr 19;288(16):11312-24. Epub 2013 Mar 11.
May 31
Jeannette Vasquez-Vivar, PhD Associate Professor
Department of Biophysics
Li LL, Ginet V, Liu X, Vergun O, Tuittila M, Mathieu M, Bonny C, Puyal J, Truttmann AC, Courtney MJ. The nNOS-p38MAPK Pathway Is Mediated by NOS1AP during Neuronal Death. J Neurosci. 2013 May 8;33(19):8185-8201.

 

Work-in-Progress Sessions

 

Date and Speaker Topic
Feb. 7
Jeannette Vasquez-Vivar, PhD
Associate Professor
Department of Biophysics
Tetrahydrobiopterin in the Prevention and Treatment of Endothelial Dysfunction
April 4
Andrey Sorokin, PhD
Professor
Department of Medicine
Division of Nephrology
Role of Redox Protein p66 Shc in Renal Pathologies
May 2
Rodney E. Willoughby, MD
Pediatric Infectious Disease Specialist

Children's Hospital of Wisconsin

 

Infection Causing H2S Toxicity

 

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