Redox Biology Program

EmailEmail    |   Bookmark Page Bookmark  |   RSS Feeds RSS  |   Print Page Print  

Spring 2014

The Redox Biology Program hosts a monthly "Works-in-Progress" session.

In addition, Albert Girotti, PhD, hosts a noon to 1 p.m. Thursday journal club each week in Room 376 of the Biochemistry Department.

The focus of the Oxidative Signaling Journal Club is to examine recent manuscripts regarding oxidative signaling pathways with responses ranging from cell proliferation to cell senescence or death. Novel sensing mechanisms and sensor proteins responding to ROS or RNS redox are of particular interest.


Oxidative Signaling Journal Club


Date and SpeakerTitle of Manuscript Presented
Jan. 10
Witold Korytowski, PhD, DSc
Assistant Professor
Department of Biochemistry
Schumacker PT. Nitric oxide quenches the fire in heart mitochondria. Nat Med. 2013 Jun;19(6):666-7.
Jan. 17
Neil Hogg, PhD
Professor
Department of Biophysics
Sabharwal SS, Waypa GB, Marks JD, Schumacker PT. Peroxiredoxin-5 targeted to the mitochondrial intermembrane space attenuates hypoxia-induced reactive oxygen species signalling. Biochem J. 2013 Dec 15;456(3):337-46.
Jan. 24
Kasia Broniowska, PhD
Postdoctoral Fellow
Department of Biochemistry
Allagnat F, Klee P, Cardozo AK, Meda P, Haefliger JA. Connexin36 contributes to INS-1E cells survival through modulation of cytokine-induced oxidative stress, ER stress and AMPK activity.  Cell Death Differ. 2013 Dec;20(12):1742-52
Jan. 31
John Corbett, PhD
Chairman and Professor
Department of Biochemistry
Yagishita Y, Fukutomi T, Sugawara A, Kawamura H, Takahashi T, Pi J, Uruno A, Yamamoto M. Nrf2 Protects Pancreatic β-Cells From Oxidative and Nitrosative Stress in Diabetic Model Mice. Diabetes. 2014 Feb;63(2):605-18.
Feb. 7
Jeannette M. Vasquez-Vivar, PhD
Associate Professor
Department of Biophysics
Di Lorenzo A, Lin MI, Murata T, Landskroner-Eiger S, Schleicher M, Kothiya M, Iwakiri Y, Yu J, Huang PL, Sessa WC. eNOS-derived nitric oxide regulates endothelial barrier function through VE-cadherin and Rho GTPases. J Cell Sci. 2013 Dec 15;126(Pt 24):5541-52.
Feb. 21
Canceled
Canceled
Feb. 28
Ching-Fang Chang
Graduate Student
Department of Biophysics
Lopez-Rivera E, Jayaraman P, Parikh F, Davies MA, Ekmekcioglu S, Izadmehr S, Milton DR, Chipuk JE, Grimm EA, Estrada Y, Aguirre-Ghiso J, Sikora AG. Inducible nitric oxide synthase (iNOS) drives mTOR pathway activation and proliferation of human melanoma by reversible nitrosylation of TSC2. Cancer Res. 2014 Feb 15;74(4):1067-78.
March 7
Jonathan Fahey
Research Technologist
Department of Biochemistry
Kim RK, Suh Y, Cui YH, Hwang E, Lim EJ, Yoo KC, Lee GH, Yi JM, Kang SG, Lee SJ. Fractionated radiation-induced nitric oxide promotes expansion of glioma stem-like cells. Cancer Sci. 2013 Sep;104(9):1172-7.
March 14
Tyler Lee
Research Technologist
Department of Biochemistry
Ishaq M, Kumar S, Varinli H, Han Z, Rider AE, Evans MD, Murphy AB, Ostrikov KK. Atmospheric gas plasma-induced ROS production activates TNF-ASK1 pathway for the induction of melanoma cancer cell apoptosis.  Mol Biol Cell. 2014 Feb 26. [Epub ahead of print]
March 21
Savitha Sethumadhavan, PhD
Postdoctoral Fellow
Department of Biophysics
Tseng AH, Shieh SS, Wang DL. SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage. Free Radic Biol Med. 2013 Oct;63:222-34.
March 28
Jung Ja P Kim, PhD
Professor
Department of Biochemistry
Giangregorio N, Palmieri F, Indiveri C. Glutathione controls the redox state of the mitochondrial carnitine/acylcarnitine carrier Cys residues by glutathionylation. Biochim Biophys Acta. 2013 Nov;1830(11):5299-304.
April 11
Witold Korytowski, PhD, DSc
Assistant Professor
Department of Biochemistry
Zucker SN, Fink EE, Bagati A, Mannava S, Bianchi-Smiraglia A, Bogner PN, Wawrzyniak JA, Foley C, Leonova KI, Grimm MJ, Moparthy K, Ionov Y, Wang J, Liu S, Sexton S, Kandel ES, Bakin AV, Zhang Y, Kaminski N, Segal BH, Nikiforov MA. Nrf2 Amplifies Oxidative Stress via Induction of Klf9. Mol Cell. 2014 Mar 20;53(6):916–28. 
April 18
Bryndon Oleson
Graduate Student
Department of Biochemistry
Cheung EC, Ludwig RL, Vousden KH. Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death. Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20491–6.

 

Work-in-Progress Sessions


Date and SpeakerTopic
Feb. 6
Allison Ebert, PhD
Assistant Professor
Department of Cell Biology,
Neurobiology and Anatomy
Using induced pluripotent stem cells to model human disease
March 6
Andreas Beyer, PhD
Assistant Professor
Department of Medicine/Cardiology
Novel role of the catalytic subunit of telomerase as a regulator of endothelial redox environment


webmaster@mcw.edu
© 2014 Medical College of Wisconsin
Page Updated 04/17/2014