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    Preventing Kidney Disease in Children with Congenital Heart Conditions

    Scientists from the Medical College of Wisconsin (MCW) and Children’s Hospital of Wisconsin received a one-year, $50,000 grant from the Clinical and Translational Science Institute of Southeast Wisconsin (CTSI) to study acute kidney injury in children who have had cardiopulmonary bypass.

    The primary investigators are John Scott, MD, assistant professor of anesthesiology and pediatrics at MCW, anesthesiologist at Children’s Hospital and researcher at Children’s Research Institute at Children’s Hospital of Wisconsin; and David Hehir, MD, assistant professor of pediatrics at MCW, critical care physician at Children’s Hospital and researcher at Children’s Research Institute. Co-investigators are Aaron Dall, MD, assistant professor of medicine – nephrology and nephrologist practicing at Froedtert Hospital; and Michael Mitchell, MD, associate professor of cardiothoracic surgery cardiothoracic surgeon at Children’s Hospital and researcher at Children’s Research Institute. 

    Children who undergo surgery for congenital heart disease have a high incidence of acute kidney injury (AKI). Collaborators in this research project will investigate risk factors for AKI and evaluate biomarkers in AKI in the hopes of allowing clinicians to identify the development of AKI more quickly, and develop new therapies for rapid treatment. 

    This is one of 19 pilot projects being funded in 2012 through CTSI. The goal is to create synergy through collaboration, and studies are specifically designed to lead to major future research support. The projects explore findings that have the potential to be translated into clinical practice and community health, and are led by investigators at the CTSI’s eight partnering institutions: the Medical College of Wisconsin, Marquette University, Milwaukee School of Engineering, UW-Milwaukee, Froedtert Hospital, Children’s Hospital of Wisconsin, the VA Medical Center, and the BloodCenter of Wisconsin. 

    CTSI is part of a national consortium of top medical research institutions. Working together, the CTSI institutions are committed to improve human health by streamlining science, transforming training environments and improving the conduct, quality and dissemination of clinical and translational research. The CTSI program is led by the National Center for Advancing Translational Sciences, part of the National Institutes of Health.

    Support for the Pilot Award Program comes from the National Institutes of Health and the John and Jeanne Byrnes CTSI Award, and the Medical College of Wisconsin’s Advancing a Healthier Wisconsin program, and its Biotechnology and Bioengineering Center.