Medical College Researcher to Study Mechanisms of Coronary Artery Disease
The Medical College of Wisconsin has received a four-year, $1.7 million grant from the National Institutes of Health’s National Heart, Lung and Blood Institute to study the mechanisms and agents influencing blood flow to the heart.
David Gutterman, MD, Northwestern Mutual Professor of Cardiovascular Medicine, is the primary investigator of the grant.
Coronary artery disease, which results in abnormalities of the small blood vessels that supply blood and oxygen to the heart, is the leading cause of death in the United States of both men and women. By learning how the small blood vessels are dysfunctional in heart disease it is hoped that improved heart function might be possible. There is little understanding of the changes in vascular function over time and with the onset of disease in humans.
In this project, researchers will attempt to determine the mechanisms involved in vascular homeostasis (the balance between blood vessel injury and repair) in health and disease. That information will in turn lead to increased knowledge about the factors involved in the transition from a healthy cardiovascular system, to disease.